Photocatalysis as a tool for synthetic organic chemistry

Información del proyecto

PhotoReAct

Identificador del acuerdo de subvención: 956324

DOI

10.3030/956324

Proyecto cerrado

Fecha de la firma de la CE 4 Septiembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 30 Junio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 989 767,02

Aportación de la UE

€ 3 989 767,02

Coordinado por

UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

Short Movie Script

Short movie about 1 minute about the advantages of photocatalysis for the public Will be distributed via our social media channels

website, twitter and instragram accounts

Social media and website are online and will be maintained by the students.

Press Release

Press release on the goals of PhotoReAct

Other (2)

PhotoReAct T-shirt

Tshirt designed by the students which will be printed for all students beneficiaries and partner organizations

Publication vacancies

online publication

Documents, reports (3)

Program Schools - Part 1

Overview of the program at the winter and summer schools

Photocatalytic method that engages uncharged radical precursors to yield novel building blocks for the synthesis of pharmaceuticals and agrochemicals - Intermediate Evaluation

Intermediate update on the status of the synthetic method

Program Schools - Part 2

Overview of the program at the winter and summer schools

Publicaciones

Peer reviewed articles (29)

Moving Beyond Cyanoarene Thermally Activated Delayed Fluorescence Compounds as Photocatalysts: An Assessment of the Performance of a Pyrimidyl Sulfone Photocatalyst in Comparison to 4CzIPN

Autores: Megan Amy Bryden; Francis Millward; Tomas Matulaitis; Dongyang Chen; Marco Villa; Andrea Fermi; Sultan Cetin; Paola Ceroni; Eli Zysman-Colman
Publicado en: The Journal of Organic Chemistry, Edición 16-05-2022, 2022, ISSN 0022-3263
Editor: American Chemical Society
DOI: 10.1021/acs.joc.2c01137

Automated One‐Pot Library Synthesis with Aldehydes as Radical Precursors

Autores: Adrián Luguera Ruiz, Brenda Pijper, Maria Lourdes Linares, Santiago Cañellas, Stefano Protti, Maurizio Fagnoni, Jesús Alcázar
Publicado en: Chemistry–Methods, Edición 5, 2025, ISSN 2628-9725
Editor: Wiley
DOI: 10.1002/cmtd.202400029

Organophotocatalyzed C−Si Bond Fragmentation Using Silyl Ethers as Radical Precursors

Autores: Adrián Luguera Ruiz, Valentina Benazzi, Federico Tucci, Francesca Rizzo, Daniele Merli, Stefano Protti, Maurizio Fagnoni
Publicado en: Advanced Synthesis & Catalysis, Edición 366, 2024, Página(s) 4132-4138, ISSN 1615-4150
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202400584

Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow

Autores: Luca Capaldo; Stefano Bonciolini; Antonio Pulcinella; Manuel Nuño; Timothy Noël
Publicado en: Chemical Science, Edición 28-05-2022, 2022, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sc01581a

Photochemical cyclopropanation in aqueous micellar media – experimental and theoretical studies

Autores: Joseph P. Milton, Adam Milanowski, Martin Andersson, Dorota Gryko
Publicado en: Chemical Communications, Edición 60, 2024, Página(s) 4483-4486, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d4cc00828f

Development of an Automated Platform for C(sp3)−C(sp3) Bond Formation via XAT Chemistry

Autores: Brenda Pijper, Irini Abdiaj, Daniele Leonori, Jesus Alcázar
Publicado en: ChemCatChem, Edición 21-12-2022, 2022, ISSN 1867-3899
Editor: Chemistry Europe
DOI: 10.1002/cctc.202201289

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Autores: Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne A. J. Dubois, Ranganath Gopalakrishnan, Geraldine Masson, Nicola Della Ca’, Stefano Protti, Maurizio Fagnoni, Eli Zysman-Colman, Magnus Johansson, Timothy Noël
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45804-z

Automated self-optimization, intensification, and scale-up of photocatalysis in flow

Autores: Aidan Slattery, Zhenghui Wen, Pauline Tenblad, Jesús Sanjosé-Orduna, Diego Pintossi, Tim den Hartog, Timothy Noël
Publicado en: Science, Edición 383, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adj1817

Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications

Autores: Matteo Gasparetto, Balázs Fődi, Gellért Sipos
Publicado en: Beilstein Journal of Organic Chemistry, Edición 20, 2024, Página(s) 1922-1932, ISSN 1860-5397
Editor: Beilstein-Institut
DOI: 10.3762/bjoc.20.168

A strategy for ortho-phenylenediamine synthesis via dearomative-rearomative coupling of nitrobenzenes and amines

Autores: Raquel Sánchez-Bento, Baptiste Roure, Josep Llaveria, Alessandro Ruffoni, Daniele Leonori
Publicado en: Chem, Edición 9, 2023, Página(s) 3685-3695, ISSN 2451-9294
Editor: Elsevier BV
DOI: 10.1016/j.chempr.2023.10.008

Geometric Isomerisation of Bifunctional Alkenyl Fluoride Linchpins: Stereodivergence in Amide and Polyene Bioisostere Synthesis

Autores: Max Wienhold, Byeongseok Kweon, Calum McLaughlin, Matthias Schmitz, Till J. B. Zähringer, Constantin G. Daniliuc, Christoph Kerzig, Ryan Gilmour
Publicado en: Angewandte Chemie International Edition, Edición 62, 2025, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202304150

Regio‐ and Stereo‐Selective Isomerization of Borylated 1,3‐Dienes Enabled by Selective Energy Transfer Catalysis

Autores: Byeongseok Kweon, Lukas Blank, Julia Soika, Amélia Messara, Constantin G. Daniliuc, Ryan Gilmour
Publicado en: Angewandte Chemie, Edición 136, 2024, ISSN 0044-8249
Editor: Wiley
DOI: 10.1002/ange.202404233

Photochemical Functionalization of 4-Diazoisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones and Their 1-Sulfoxide Analogues

Autores: Joseph P. Milton, Dorota Gryko
Publicado en: ACS Organic &amp; Inorganic Au, Edición 5, 2025, Página(s) 205-210, ISSN 2694-247X
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsorginorgau.5c00017

TBADT‐Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N‐Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines

Autores: Matteo Leone, Joseph P. Milton, Dorota Gryko, Luc Neuville, Géraldine Masson
Publicado en: Chemistry – A European Journal, Edición 30, 2024, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202400363

Photoredox catalyzed release of carbon-based radicals from 2-substituted-1,3-imidazolidines

Autores: Adrián Luguera Ruiz, Elena Mariani, Stefano Protti, Maurizio Fagnoni
Publicado en: Organic Chemistry Frontiers, Edición 11, 2024, Página(s) 661-667, ISSN 2052-4129
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3qo01856c

Light-Induced Access to Carbazole-1,3-dicarbonitrile: A Thermally Activated Delayed Fluorescent (TADF) Photocatalyst for Cobalt-Mediated Allylations

Autores: Emanuele Pinosa; Elena Bassan; Sultan Cetin; Marco Villa; Simone Potenti; Francesco Calogero; Andrea Gualandi; Andrea Fermi; Paola Ceroni; Pier Giorgio Cozzi
Publicado en: The Journal of Organic Chemistry, Edición 16-10-2022, 2022, ISSN 0022-3263
Editor: American Chemical Society
DOI: 10.1021/acs.joc.2c01825

Fully Automated Flow Protocol for C(sp³)–C(sp³) Bond Formation from Tertiary Amides and Alkyl Halides

Autores: Brenda Pijper, Raúl Martín, Alberto J. Huertas-Alonso, Maria Lourdes Linares, Enol López, Josep Llaveria, Ángel Díaz-Ortiz, Darren J. Dixon, Antonio de la Hoz, Jesús Alcázar
Publicado en: Organic Letters, Edición 26, 2024, Página(s) 2724-2728, ISSN 1523-7060
Editor: American Chemical Society
DOI: 10.1021/acs.orglett.3c01390

A Photochemical Strategy for the Synthesis of Caprolactams via Dearomative Ring Expansion of Nitroarenes

Autores: Alessandro Ruffoni, Daniele Leonori, Raquel Sánchez-Bento, Linda Bui, Vincent K. Duong
Publicado en: Synthesis, Edición 56, 2024, Página(s) 2385-2391, ISSN 0039-7881
Editor: Georg Thieme Verlag
DOI: 10.1055/a-2288-6944

Photocatalytic Asymmetric Acyl Radical Truce–Smiles Rearrangement for the Synthesis of Enantioenriched α‐Aryl Amides

Autores: Wei‐Yang Ma, Matteo Leone, Etienne Derat, Pascal Retailleau, Chada Raji Reddy, Luc Neuville, Géraldine Masson
Publicado en: Angewandte Chemie International Edition, Edición 63, 2024, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202408154

Building a photocatalyst library of MR-TADF compounds with tunable excited-state redox potentials

Autores: Lea Hämmerling, Eli Zysman-Colman
Publicado en: Chem Catalysis, Edición 4, 2024, Página(s) 101061, ISSN 2667-1093
Editor: Elsevier BV
DOI: 10.1016/j.checat.2024.101061

Addressing Reproducibility Challenges in High-Throughput Photochemistry

Autores: Brenda Pijper, Lucía M. Saavedra, Matteo Lanzi, Maialen Alonso, Alberto Fontana, Marta Serrano, José Enrique Gómez, Arjan W. Kleij, Jesús Alcázar, Santiago Cañellas
Publicado en: JACS Au, Edición 4, 2024, Página(s) 2585-2595, ISSN 2691-3704
Editor: American Chemical Society (ACS)
DOI: 10.1021/jacsau.4c00312

Selective and scalable oxygenation of heteroatoms using the elements of nature: air, water, and light

Autores: Damiano Diprima, Hannes Gemoets, Stefano Bonciolini, Koen Van Aken
Publicado en: Beilstein Journal of Organic Chemistry, Edición 19, 2023, Página(s) 1146-1154, ISSN 1860-5397
Editor: Beilstein-Institut
DOI: 10.3762/bjoc.19.82

Alkyl Radical Generation via C-C Bond Cleavage in 2-Substituted Oxazolidines

Autores: Luguera Ruiz, A.; La Mantia, M.; Merli, D.; Protti, S.; Fagnoni, M.
Publicado en: ACS Catalysis, 2022, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.2c03768

Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines

Autores: Antonio Pulcinella, Stefano Bonciolini, Robin Stuhr, Damiano Diprima, Minh Thao Tran, Magnus Johansson, Axel Jacobi von Wangelin, Timothy Noël
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-56234-w

Syntheses of new chiral chimeric photo-organocatalysts

Autores: Jiyaun Lyu; Matteo Leone; Aurélie Claraz; Clémence Allain; Luc Neuville; Géraldine Masson
Publicado en: RSC Advances, Edición 15-11-2021, 2021, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/d1ra06885g

Photocatalytic Alkylation of C(sp ³ )−H Bonds Using Sulfonylhydrazones**

Autores: Antonio Pulcinella; Stefano Bonciolini; Florian Lukas; Andrea Sorato; Timothy Noël
Publicado en: Angewandte Chemie International Edition, Edición 17-11-2022, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215374

End-to-End Automated Synthesis of C(sp³)-Enriched Drug-like Molecules <i>via</i> Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

Autores: Irini Abdiaj; Santiago Cañellas; Alejandro Dieguez; Maria Lourdes Linares; Brenda Pijper; Alberto Fontana; Raquel Rodriguez; Andres Trabanco; Eduardo Palao; Jesus Alcázar
Publicado en: Journal of Medicinal Chemistry, Edición 15-12-2022, 2022, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01646

Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes

Autores: Rory Mykura, Raquel Sánchez-Bento, Esteban Matador, Vincent K. Duong, Ana Varela, Lucrezia Angelini, Rodrigo J. Carbajo, Josep Llaveria, Alessandro Ruffoni, Daniele Leonori
Publicado en: Nature Chemistry, Edición 16, 2024, Página(s) 771-779, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-023-01429-1

Multistep and multivectorial assembly line library synthesis in flow

Autores: Brenda Pijper, Irini Abdiaj, Javier Mazuela, Maria Lourdes Linares, José Enrique Gómez, Raquel Rodriguez, Belén Chaves Arquero, Eduardo Palao, Santiago Cañellas, Jesús Alcázar
Publicado en: Chem Catalysis, Edición 4, 2024, Página(s) 101118, ISSN 2667-1093
Editor: Elsevier BV
DOI: 10.1016/j.checat.2024.101118

Other (3)

Synthetic Applications of Photocatalyzed Halogen-Radical Mediated Hydrogen Atom Transfer for C−H Bond Functionalization

Autores: Stefano Bonciolini, Timothy Noel, Luca Capaldo
Publicado en: EurJOC, Edición 12-05-2022, 2022, ISSN 1099-0690
Editor: Wiley-VCH
DOI: 10.1002/ejoc.202200417

Recent Developments in Radical Mediated Synthesis of Organostannanes.

Autores: Qianhang Ren, Adrian Luguera Ruiz, Maurizio Fagnoni, Stefano Protti, Di Qiu
Publicado en: Advanced Synthesis &amp; Catalysis, Edición 367, 2025, ISSN 1615-4150
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202500243

The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation

Autores: John Marques Dos Santos, David Hall, Biju Basumatary, Megan Bryden, Dongyang Chen, Praveen Choudhary, Thomas Comerford, Ettore Crovini, Andrew Danos, Joydip De, Stefan Diesing, Mahni Fatahi, Máire Griffin, Abhishek Kumar Gupta, Hassan Hafeez, Lea Hämmerling, Emily Hanover, Janine Haug, Tabea Heil, Durai Karthik, Shiv Kumar, Oliver Lee, Haoyang Li, Fabien Lucas, Campbell Frank Ross Mackenzie, Ami
Publicado en: Chemical Reviews, Edición 124, 2025, Página(s) 13736-14110, ISSN 0009-2665
Editor: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00755

Non-peer reviewed articles (7)

Bio-Inspired Deconjugative Isomerization of Borylated Dienoates

Autores: Amélia Messara, Byeongseok Kweon, Ferdinand Woge, Constantin Daniliuc, Ryan Gilmour
Publicado en: ChemRxiv, 2025, ISSN 2573-2293
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-nlmz9

DiICz MR-TADF Emitters as Energy Transfer Photocatalysts

Autores: Lea Hämmerling, David Hall, Eliott Blin, Tabea Heil, Eli Zysman-Colman
Publicado en: ChemRxiv, 2025, ISSN 2573-2293
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-gfx9c

Design and Experimental Validation of a Photocatalyst Recommender based on a Large Language Model

Autores: Francis Millward, Michał Kulczykowski, Jay Badland-Shaw, Sara Szymkuc, Rajan Suraksha, Aniket Kumar Srivastawa, Violaine Manet, Máire Griffin, Megan Bryden, Thomas Comerford, Lea Hämmerling, Aminata Mariko, Bartosz Grzybowski, Eli Zysman-Colman
Publicado en: ChemRxiv, 2025, ISSN 2573-2293
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-d2cdf

Modular Synthesis of Substituted Lactams via Deoxygenative Photochemical Alkylation-Cyclization Cascade of Secondary Amides in Flow

Autores: Damiano Diprima, Thomas Terp Paulsen, Antonio Pulcinella, Stefano Bonciolini, Alexis Gabbey, Robin Stuhr, Thomas Poulsen, Timothy Noel
Publicado en: ChemRxiv, 2025, ISSN 2573-2293
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-6qf93

Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

Autores: Brenda Pijper, Jesus Alcázar, Fabricio Roman Bisogno, Gabriela Oksdath-Mansilla
Publicado en: Chem Catalysis, Edición 19-01-2023, 2023, ISSN 2667-1093
Editor: Cell Press
DOI: 10.1016/j.checat.2022.100488

Challenge and opportunity: The two edges of continuous-flow photochemistry

Autores: Gabriela Oksdath-Mansilla, Fabricio Roman Bisogno, Brenda Pijper, Jesus Alcázar
Publicado en: Chem Catalysis, Edición 19-01-2023, 2023, ISSN 2667-1093
Editor: Cell Press
DOI: 10.1016/j.checat.2022.100487

Dual Nickel-Photoredox Catalyzed Amidine-Arylation Method Mediated By In Situ Generated Triazine Cocatalyst

Autores: Matteo Gasparetto, Attila Sveiczer, Andrea Fermi, Mounir Raji, Richard J. Fair, Paola Ceroni, Gellért Sipos
Publicado en: ChemRxiv, 2025, ISSN 2573-2293
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2025-hlzgd