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CORDIS - EU research results
CORDIS

Directing the immune response through designed nanomaterials

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

First report on relationship between NP coating, biomolecular corona and complement activation (opens in new window)

First report describing the relationship between nanoparticle coating, biomolecular corona, and complement activation

Report on the effects of loaded NPs and nanovaccines on xenograft tumor growth (opens in new window)

Report on the effects of NPs and nanovaccines on xenograft tumor growth

Final report on interactions of NPs with immune cells and molecules (opens in new window)

Final report on interactions of NP with immune cells and molecules

Report on effects of selected NPs in in vivo tumor models (opens in new window)
Supervisory Board of the Network (opens in new window)

Document establishing the supervisory board and defining the way of working

Report on the synthesis of advanced polymers for NP coating (opens in new window)

Report on the synthesis of advanced polymers and lipids for NP coating

Report on nanovaccine localization in the mouse immune system (opens in new window)
Report on the toxicity profiling of nanovaccines (opens in new window)
Reports on dissemination activities (opens in new window)

Reports on dissemination activities (RDA) (web, newsletter, social)-RDA1:month 24-RDA2:month 48

Report on humoral and cellular immunity induced by nanovaccines after the first immunization campaign (opens in new window)

Report on humoral and cellular immunity induced by nanovaccines in vitro and after the first immunization campaign

Report on the preparation of second generation optimized NPs (opens in new window)

Report on preparation of second generation (optimized) NPs

Report on preparation of first generation NPs and protocol selecting NPs monodispersed in biological media (opens in new window)

Report on the preparation of first generation NPs and protocol for a standardized procedure for selecting NPs which remain monodispersed in relevant biological media

First report on interactions of NPs with immune cells and molecules (opens in new window)

First report on interactions of NP with immune cells and molecules

Report on the development of monoclonal antibodies for selected corona proteins (opens in new window)

Report on the development of monoclonal antibodies against selected corona proteins and specie-specific immune assays

Report on preparation of NPs functionalized with antigens and antigen mimics (opens in new window)
Report on the effects of nanovaccines on lung metastases (opens in new window)

Report on the effects of loaded NPs and nanovaccines on lung metastases

ESRs recruited (opens in new window)
Summer schools (opens in new window)

Summer schools (SS) schedule:-SS1: month 8-SS2: month 20-SS3:month 32

Compilation of a structure-activity relationship chart summarizing how the various NP coatings affect the immune response (with WP1) (opens in new window)

Compilation of a structure-activity relationship chart summarizing how the various NP coatings affect the immune response (together with WP2)

Protocols for the preparation and characterization of collectin analogues (opens in new window)

Protocols for the preparation and characterization of collectin analogues and derivatives

Exchange of expertise between academia and industry, including spin-off generation (opens in new window)

Exchange of expertise between academia and industry, including spin-off generation (EXC)-EXC1:month 24-EXC 2:month 48

Technical and transferable skills workshops (opens in new window)

Technical and transferable skills workshops (WS).Workshops schedule:-WS1:month 12-WS2:month 18-WS3:month 24-WS4:month 30-WS5:Month 36

Protocol for cancer nanovaccine candidates and administration routes: animal experimentation ethics committee approval (opens in new window)

Approval from animal experimentation ethics committee, identification of an objective selection protocol for promising cancer nanotherapeutics and nanovaccine candidates, and of prospective administration routes

Protocol for endotoxin profiling on NP formulations (opens in new window)

Advanced protocol for endotoxin profiling on nanoparticle based formulations

Publications in the open access primary literature (opens in new window)

Publications in the open access (POA) primary literaturePOA1:month 24POA2:month 48

International conference attendance (opens in new window)

International conference (IC) attendance schedule:IC1:month 24IC2:month 48

Website (opens in new window)
Final conference (opens in new window)

two-day conference to showcase the research area and the achievements of thenetwork, also accessible to the general public

Publications

Polymer functionalization of inorganic nanoparticles for biomedical applications (opens in new window)

Author(s): Tobias Komsthöft, Giovanni Bovone, Stéphane Bernhard, Mark W Tibbitt
Published in: Current Opinion in Chemical Engineering, Issue 37, 2022, Page(s) 100849, ISSN 2211-3398
Publisher: Elsevier BV
DOI: 10.1016/j.coche.2022.100849

Non‐Fouling Multi‐Azide Polyoxazoline Brush‐co‐Polymers for Sensing Applications (opens in new window)

Author(s): Tobias Komsthöft, Niccolò Bartalucci, Mark W. Tibbitt, Samuele Tosatti, Stefan Zürcher
Published in: Advanced Materials Interfaces, Issue 11, 2024, ISSN 2196-7350
Publisher: Advanced Materials Interfaces published by Wiley-VCH GmbH
DOI: 10.1002/admi.202400322

Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes (opens in new window)

Author(s): Francisco Corzana, Alicia Asín, Ander Eguskiza, Elisa De Tomi, Alfonso Martín‐Carnicero, María P. Martínez‐Moral, Vincenzo Mangini, Francesco Papi, Carmen Bretón, Paula Oroz, Laura Lagartera, Ester Jiménez‐Moreno, Alberto Avenoza, Jesús H. Busto, Cristina Nativi, Juan L. Asensio, Ramón Hurtado‐Guerrero, Jesús M. Peregrina, Giovanni Malerba, Alfredo Martínez, Roberto Fiammengo
Published in: Angewandte Chemie, Issue 136, 2024, ISSN 0044-8249
Publisher: WILEY-VCH GmbH
DOI: 10.1002/ange.202407131

A brief history of long circulating nanoparticles (opens in new window)

Author(s): H.B. Haroon, A.C. Hunter, Z.S. Farhangrazi, S.M. Moghimi
Published in: Advanced Drug Delivery Reviews, Issue Volume 188, 2022, Page(s) 114396, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114396

Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants (opens in new window)

Author(s): Remya Valsalakumari, Abhilash Pandya, Lina Prasmickaite, Audun Kvalvaag, Anne Myrann, Andreas Åslund, Marianne Kjos, Cristina Fontecha-Cuenca, Hajira Haroon, Ana Ribeiro, Jutta Horejs-Hoeck, S Moein Moghimi, Ýrr Mørch, Tore Skotland, Kirsten Sandvig, Gunhild Mælandsmo, Tore Geir Iversen
Published in: International Journal of Nanomedicine, Issue Volume 19, 2024, Page(s) 3009-3029, ISSN 1178-2013
Publisher: Dove Medical Press
DOI: 10.2147/ijn.s450283

Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles (opens in new window)

Author(s): S.M. Moghimi, H.B. Haroon, A. Yaghmur, D. Simberg, P.N. Trohopoulos
Published in: Journal of Controlled Release, Issue Volume 351, 2022, Page(s) 432-443, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.09.039

Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona (opens in new window)

Author(s): Maria Morbidelli, Emanuele Papini, Regina Tavano
Published in: Frontiers in Nanotechnology, Issue 6, 2024, ISSN 2673-3013
Publisher: Frontiers Media SA
DOI: 10.3389/fnano.2024.1500567

Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses (opens in new window)

Author(s): Iris A. Bermejo, Ana Guerreiro, Ander Eguskiza, Nuria Martínez-Sáez, Foivos S. Lazaris, Alicia Asín, Víctor J. Somovilla, Ismael Compañón, Tom K. Raju, Srdan Tadic, Pablo Garrido, Josune García-Sanmartín, Vincenzo Mangini, Ana S. Grosso, Filipa Marcelo, Alberto Avenoza, Jesús H. Busto, Fayna García-Martín, Ramón Hurtado-Guerrero, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Alfredo M
Published in: JACS Au, Issue 4, 2024, Page(s) 150-163, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00587

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