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CORDIS - Forschungsergebnisse der EU
CORDIS

Directing the immune response through designed nanomaterials

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Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

First report on relationship between NP coating, biomolecular corona and complement activation (öffnet in neuem Fenster)

First report describing the relationship between nanoparticle coating, biomolecular corona, and complement activation

Report on the effects of loaded NPs and nanovaccines on xenograft tumor growth (öffnet in neuem Fenster)

Report on the effects of NPs and nanovaccines on xenograft tumor growth

Final report on interactions of NPs with immune cells and molecules (öffnet in neuem Fenster)

Final report on interactions of NP with immune cells and molecules

Report on effects of selected NPs in in vivo tumor models (öffnet in neuem Fenster)
Supervisory Board of the Network (öffnet in neuem Fenster)

Document establishing the supervisory board and defining the way of working

Report on the synthesis of advanced polymers for NP coating (öffnet in neuem Fenster)

Report on the synthesis of advanced polymers and lipids for NP coating

Report on nanovaccine localization in the mouse immune system (öffnet in neuem Fenster)
Report on the toxicity profiling of nanovaccines (öffnet in neuem Fenster)
Reports on dissemination activities (öffnet in neuem Fenster)

Reports on dissemination activities (RDA) (web, newsletter, social)-RDA1:month 24-RDA2:month 48

Report on humoral and cellular immunity induced by nanovaccines after the first immunization campaign (öffnet in neuem Fenster)

Report on humoral and cellular immunity induced by nanovaccines in vitro and after the first immunization campaign

Report on the preparation of second generation optimized NPs (öffnet in neuem Fenster)

Report on preparation of second generation (optimized) NPs

Report on preparation of first generation NPs and protocol selecting NPs monodispersed in biological media (öffnet in neuem Fenster)

Report on the preparation of first generation NPs and protocol for a standardized procedure for selecting NPs which remain monodispersed in relevant biological media

First report on interactions of NPs with immune cells and molecules (öffnet in neuem Fenster)

First report on interactions of NP with immune cells and molecules

Report on the development of monoclonal antibodies for selected corona proteins (öffnet in neuem Fenster)

Report on the development of monoclonal antibodies against selected corona proteins and specie-specific immune assays

Report on preparation of NPs functionalized with antigens and antigen mimics (öffnet in neuem Fenster)
Report on the effects of nanovaccines on lung metastases (öffnet in neuem Fenster)

Report on the effects of loaded NPs and nanovaccines on lung metastases

ESRs recruited (öffnet in neuem Fenster)
Summer schools (öffnet in neuem Fenster)

Summer schools (SS) schedule:-SS1: month 8-SS2: month 20-SS3:month 32

Compilation of a structure-activity relationship chart summarizing how the various NP coatings affect the immune response (with WP1) (öffnet in neuem Fenster)

Compilation of a structure-activity relationship chart summarizing how the various NP coatings affect the immune response (together with WP2)

Protocols for the preparation and characterization of collectin analogues (öffnet in neuem Fenster)

Protocols for the preparation and characterization of collectin analogues and derivatives

Exchange of expertise between academia and industry, including spin-off generation (öffnet in neuem Fenster)

Exchange of expertise between academia and industry, including spin-off generation (EXC)-EXC1:month 24-EXC 2:month 48

Technical and transferable skills workshops (öffnet in neuem Fenster)

Technical and transferable skills workshops (WS).Workshops schedule:-WS1:month 12-WS2:month 18-WS3:month 24-WS4:month 30-WS5:Month 36

Protocol for cancer nanovaccine candidates and administration routes: animal experimentation ethics committee approval (öffnet in neuem Fenster)

Approval from animal experimentation ethics committee, identification of an objective selection protocol for promising cancer nanotherapeutics and nanovaccine candidates, and of prospective administration routes

Protocol for endotoxin profiling on NP formulations (öffnet in neuem Fenster)

Advanced protocol for endotoxin profiling on nanoparticle based formulations

Publications in the open access primary literature (öffnet in neuem Fenster)

Publications in the open access (POA) primary literaturePOA1:month 24POA2:month 48

International conference attendance (öffnet in neuem Fenster)

International conference (IC) attendance schedule:IC1:month 24IC2:month 48

Website (öffnet in neuem Fenster)
Final conference (öffnet in neuem Fenster)

two-day conference to showcase the research area and the achievements of thenetwork, also accessible to the general public

Veröffentlichungen

Polymer functionalization of inorganic nanoparticles for biomedical applications (öffnet in neuem Fenster)

Autoren: Tobias Komsthöft, Giovanni Bovone, Stéphane Bernhard, Mark W Tibbitt
Veröffentlicht in: Current Opinion in Chemical Engineering, Ausgabe 37, 2022, Seite(n) 100849, ISSN 2211-3398
Herausgeber: Elsevier BV
DOI: 10.1016/j.coche.2022.100849

Non‐Fouling Multi‐Azide Polyoxazoline Brush‐co‐Polymers for Sensing Applications (öffnet in neuem Fenster)

Autoren: Tobias Komsthöft, Niccolò Bartalucci, Mark W. Tibbitt, Samuele Tosatti, Stefan Zürcher
Veröffentlicht in: Advanced Materials Interfaces, Ausgabe 11, 2024, ISSN 2196-7350
Herausgeber: Advanced Materials Interfaces published by Wiley-VCH GmbH
DOI: 10.1002/admi.202400322

Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes (öffnet in neuem Fenster)

Autoren: Francisco Corzana, Alicia Asín, Ander Eguskiza, Elisa De Tomi, Alfonso Martín‐Carnicero, María P. Martínez‐Moral, Vincenzo Mangini, Francesco Papi, Carmen Bretón, Paula Oroz, Laura Lagartera, Ester Jiménez‐Moreno, Alberto Avenoza, Jesús H. Busto, Cristina Nativi, Juan L. Asensio, Ramón Hurtado‐Guerrero, Jesús M. Peregrina, Giovanni Malerba, Alfredo Martínez, Roberto Fiammengo
Veröffentlicht in: Angewandte Chemie, Ausgabe 136, 2024, ISSN 0044-8249
Herausgeber: WILEY-VCH GmbH
DOI: 10.1002/ange.202407131

A brief history of long circulating nanoparticles (öffnet in neuem Fenster)

Autoren: H.B. Haroon, A.C. Hunter, Z.S. Farhangrazi, S.M. Moghimi
Veröffentlicht in: Advanced Drug Delivery Reviews, Ausgabe Volume 188, 2022, Seite(n) 114396, ISSN 0169-409X
Herausgeber: Elsevier BV
DOI: 10.1016/j.addr.2022.114396

Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants (öffnet in neuem Fenster)

Autoren: Remya Valsalakumari, Abhilash Pandya, Lina Prasmickaite, Audun Kvalvaag, Anne Myrann, Andreas Åslund, Marianne Kjos, Cristina Fontecha-Cuenca, Hajira Haroon, Ana Ribeiro, Jutta Horejs-Hoeck, S Moein Moghimi, Ýrr Mørch, Tore Skotland, Kirsten Sandvig, Gunhild Mælandsmo, Tore Geir Iversen
Veröffentlicht in: International Journal of Nanomedicine, Ausgabe Volume 19, 2024, Seite(n) 3009-3029, ISSN 1178-2013
Herausgeber: Dove Medical Press
DOI: 10.2147/ijn.s450283

Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles (öffnet in neuem Fenster)

Autoren: S.M. Moghimi, H.B. Haroon, A. Yaghmur, D. Simberg, P.N. Trohopoulos
Veröffentlicht in: Journal of Controlled Release, Ausgabe Volume 351, 2022, Seite(n) 432-443, ISSN 0168-3659
Herausgeber: Elsevier BV
DOI: 10.1016/j.jconrel.2022.09.039

Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona (öffnet in neuem Fenster)

Autoren: Maria Morbidelli, Emanuele Papini, Regina Tavano
Veröffentlicht in: Frontiers in Nanotechnology, Ausgabe 6, 2024, ISSN 2673-3013
Herausgeber: Frontiers Media SA
DOI: 10.3389/fnano.2024.1500567

Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses (öffnet in neuem Fenster)

Autoren: Iris A. Bermejo, Ana Guerreiro, Ander Eguskiza, Nuria Martínez-Sáez, Foivos S. Lazaris, Alicia Asín, Víctor J. Somovilla, Ismael Compañón, Tom K. Raju, Srdan Tadic, Pablo Garrido, Josune García-Sanmartín, Vincenzo Mangini, Ana S. Grosso, Filipa Marcelo, Alberto Avenoza, Jesús H. Busto, Fayna García-Martín, Ramón Hurtado-Guerrero, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Alfredo M
Veröffentlicht in: JACS Au, Ausgabe 4, 2024, Seite(n) 150-163, ISSN 2691-3704
Herausgeber: American Chemical Society
DOI: 10.1021/jacsau.3c00587

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