Directing the immune response through designed nanomaterials

Informazioni relative al progetto

DIRNANO

ID dell’accordo di sovvenzione: 956544

DOI

10.3030/956544

Progetto chiuso

Data della firma CE 31 Agosto 2020

Data di avvio 1 Ottobre 2020

Data di completamento 30 Settembre 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 007 724,48

Contributo UE

€ 4 007 724,48

Coordinato da

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (16)

First report on relationship between NP coating, biomolecular corona and complement activation

First report describing the relationship between nanoparticle coating, biomolecular corona, and complement activation

Report on the effects of loaded NPs and nanovaccines on xenograft tumor growth

Report on the effects of NPs and nanovaccines on xenograft tumor growth

Final report on interactions of NPs with immune cells and molecules

Final report on interactions of NP with immune cells and molecules

Report on effects of selected NPs in in vivo tumor models
Supervisory Board of the Network

Document establishing the supervisory board and defining the way of working

Report on the synthesis of advanced polymers for NP coating

Report on the synthesis of advanced polymers and lipids for NP coating

Report on nanovaccine localization in the mouse immune system
Report on the toxicity profiling of nanovaccines
Reports on dissemination activities

Reports on dissemination activities (RDA) (web, newsletter, social)-RDA1:month 24-RDA2:month 48

Report on humoral and cellular immunity induced by nanovaccines after the first immunization campaign

Report on humoral and cellular immunity induced by nanovaccines in vitro and after the first immunization campaign

Report on the preparation of second generation optimized NPs

Report on preparation of second generation (optimized) NPs

Report on preparation of first generation NPs and protocol selecting NPs monodispersed in biological media

Report on the preparation of first generation NPs and protocol for a standardized procedure for selecting NPs which remain monodispersed in relevant biological media

First report on interactions of NPs with immune cells and molecules

First report on interactions of NP with immune cells and molecules

Report on the development of monoclonal antibodies for selected corona proteins

Report on the development of monoclonal antibodies against selected corona proteins and specie-specific immune assays

Report on preparation of NPs functionalized with antigens and antigen mimics
Report on the effects of nanovaccines on lung metastases

Report on the effects of loaded NPs and nanovaccines on lung metastases

Other (8)

ESRs recruited
Summer schools

Summer schools (SS) schedule:-SS1: month 8-SS2: month 20-SS3:month 32

Compilation of a structure-activity relationship chart summarizing how the various NP coatings affect the immune response (with WP1)

Compilation of a structure-activity relationship chart summarizing how the various NP coatings affect the immune response (together with WP2)

Protocols for the preparation and characterization of collectin analogues

Protocols for the preparation and characterization of collectin analogues and derivatives

Exchange of expertise between academia and industry, including spin-off generation

Exchange of expertise between academia and industry, including spin-off generation (EXC)-EXC1:month 24-EXC 2:month 48

Technical and transferable skills workshops

Technical and transferable skills workshops (WS).Workshops schedule:-WS1:month 12-WS2:month 18-WS3:month 24-WS4:month 30-WS5:Month 36

Protocol for cancer nanovaccine candidates and administration routes: animal experimentation ethics committee approval

Approval from animal experimentation ethics committee, identification of an objective selection protocol for promising cancer nanotherapeutics and nanovaccine candidates, and of prospective administration routes

Protocol for endotoxin profiling on NP formulations

Advanced protocol for endotoxin profiling on nanoparticle based formulations

Websites, patent fillings, videos etc. (4)

Publications in the open access primary literature

Publications in the open access (POA) primary literaturePOA1:month 24POA2:month 48

International conference attendance

International conference (IC) attendance schedule:IC1:month 24IC2:month 48

Website
Final conference

two-day conference to showcase the research area and the achievements of thenetwork, also accessible to the general public

Pubblicazioni

Peer reviewed articles (8)

Polymer functionalization of inorganic nanoparticles for biomedical applications

Autori: Tobias Komsthöft, Giovanni Bovone, Stéphane Bernhard, Mark W Tibbitt
Pubblicato in: Current Opinion in Chemical Engineering, Numero 37, 2022, Pagina/e 100849, ISSN 2211-3398
Editore: Elsevier BV
DOI: 10.1016/j.coche.2022.100849

Non‐Fouling Multi‐Azide Polyoxazoline Brush‐co‐Polymers for Sensing Applications

Autori: Tobias Komsthöft, Niccolò Bartalucci, Mark W. Tibbitt, Samuele Tosatti, Stefan Zürcher
Pubblicato in: Advanced Materials Interfaces, Numero 11, 2024, ISSN 2196-7350
Editore: Advanced Materials Interfaces published by Wiley-VCH GmbH
DOI: 10.1002/admi.202400322

Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes

Autori: Francisco Corzana, Alicia Asín, Ander Eguskiza, Elisa De Tomi, Alfonso Martín‐Carnicero, María P. Martínez‐Moral, Vincenzo Mangini, Francesco Papi, Carmen Bretón, Paula Oroz, Laura Lagartera, Ester Jiménez‐Moreno, Alberto Avenoza, Jesús H. Busto, Cristina Nativi, Juan L. Asensio, Ramón Hurtado‐Guerrero, Jesús M. Peregrina, Giovanni Malerba, Alfredo Martínez, Roberto Fiammengo
Pubblicato in: Angewandte Chemie, Numero 136, 2024, ISSN 0044-8249
Editore: WILEY-VCH GmbH
DOI: 10.1002/ange.202407131

A brief history of long circulating nanoparticles

Autori: H.B. Haroon, A.C. Hunter, Z.S. Farhangrazi, S.M. Moghimi
Pubblicato in: Advanced Drug Delivery Reviews, Numero Volume 188, 2022, Pagina/e 114396, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2022.114396

Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants

Autori: Remya Valsalakumari, Abhilash Pandya, Lina Prasmickaite, Audun Kvalvaag, Anne Myrann, Andreas Åslund, Marianne Kjos, Cristina Fontecha-Cuenca, Hajira Haroon, Ana Ribeiro, Jutta Horejs-Hoeck, S Moein Moghimi, Ýrr Mørch, Tore Skotland, Kirsten Sandvig, Gunhild Mælandsmo, Tore Geir Iversen
Pubblicato in: International Journal of Nanomedicine, Numero Volume 19, 2024, Pagina/e 3009-3029, ISSN 1178-2013
Editore: Dove Medical Press
DOI: 10.2147/ijn.s450283

Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles

Autori: S.M. Moghimi, H.B. Haroon, A. Yaghmur, D. Simberg, P.N. Trohopoulos
Pubblicato in: Journal of Controlled Release, Numero Volume 351, 2022, Pagina/e 432-443, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2022.09.039

Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona

Autori: Maria Morbidelli, Emanuele Papini, Regina Tavano
Pubblicato in: Frontiers in Nanotechnology, Numero 6, 2024, ISSN 2673-3013
Editore: Frontiers Media SA
DOI: 10.3389/fnano.2024.1500567

Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses

Autori: Iris A. Bermejo, Ana Guerreiro, Ander Eguskiza, Nuria Martínez-Sáez, Foivos S. Lazaris, Alicia Asín, Víctor J. Somovilla, Ismael Compañón, Tom K. Raju, Srdan Tadic, Pablo Garrido, Josune García-Sanmartín, Vincenzo Mangini, Ana S. Grosso, Filipa Marcelo, Alberto Avenoza, Jesús H. Busto, Fayna García-Martín, Ramón Hurtado-Guerrero, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Alfredo M
Pubblicato in: JACS Au, Numero 4, 2024, Pagina/e 150-163, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacsau.3c00587