Descrizione del progetto
Potenziare la nuova generazione di neurobiologi
Il cervello costituisce l’organo più complesso del corpo umano, capace di ricevere informazioni dall’ambiente e di incorporarle nella pianificazione e nell’esecuzione di azioni adeguate. Tuttavia, i principi di comunicazione tra diverse aree del cervello per combinare il dato sensoriale con il controllo motorio e le funzioni esecutive rimangono per lo più sconosciuti. Il progetto In2PrimateBrains, finanziato dall’UE, mira ad affrontare questo divario di conoscenze formando la nuova generazione di ricercatori attraverso l’impiego di metodologie d’avanguardia nei settori accademico, clinico e industriale, con l’obiettivo di sostenere la ricerca futura nel campo. I tirocinanti studieranno il cervello di primati non umani, il modello più simile al cervello umano, traendo informazioni importanti dalle dinamiche di comunicazione locale e a lunga distanza fino al singolo neurone.
Obiettivo
In2PrimateBrains proposes a highly competitive training-through-research program dedicated to the study of neuronal intra- and
inter-areal communication in non-human primate (NHP) brains. This program will empower the next generation of
researchers with best practices and cutting edge methodologies for studying complex neuronal activity from multiple brain
areas and across cortical layers. Our core scientific goals are to identify common and specific bottom-up and top-down
communication principles across NHP brain networks for vision, motor control and executive functions. These functions are
especially well developed in primates, and we propose to study them in a brain model as close as possible to the human
brain: the NHP brain. Critically, detailed insights into the local- and long-range dynamics of communication, down to the
single-neuron level and at millisecond precision, necessitate invasive recording, stimulation and inactivation techniques
precluding human investigations. The project entails 9 work packages with well-defined tasks to ensure success in our
research and training objectives. We propose tailored research training by world-leading European researchers from the
academic, clinical and industrial sectors. This will be accompanied by a comprehensive program of network-wide training
events including thematic workshops in essential research-related skills and soft-skill training sessions to ensure successful
careers in public or private sectors. The direct experience and acquired expertise in state-of-the-art NHP research and
technology development in different environments will drive our ESRs to pursue international, interdisciplinary and
intersectoral careers. In a highly competitive international environment, In2PrimateBrains will ensure that Europe remains at the
forefront of primate brain research in health and disease with scientists trained by the highest scientific, methodological and
ethical standards.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
13284 Marseille
Francia