The overall objective of DAPHNE is to define and build an open and extensible system infrastructure for integrated data analysis (IDA) pipelines. Such pipelines are complex workflows of data management and query processing, high-performance computing (HPC) and numerical simulations, as well as training and scoring of multiple machine learning (ML) models. Developing and deploying such IDA pipelines is still a painful process involving different systems and libraries, data exchange between these systems, inter-disciplinary development teams, different programming models and resource managers, which causes spatial-temporal underutilization of cluster hardware. Interestingly, data management, ML, and HPC share many compilation and runtime techniques, stress all aspects of the underlying hardware (HW), and thus, are affected by emerging HW challenges such as scaling limitations. These HW challenges lead to increasing specialization such as different data representations, HW accelerators, data placements, and specialized data types. Given this specialization, it becomes untenable to tune complex IDA pipelines for heterogeneous hardware. DAPHNE use cases include earth observation, semiconductor manufacturing, and automotive vehicle development, but there exist a wide variety of use cases that rely on ML-assisted simulations, data cleaning and augmentation, and exploratory query processing. In order to better support such use cases of IDA pipelines, DAPHNE’s strategic objectives include (1) a system architecture, APIs and DSLs (for developing such pipelines with seamless integration of existing systems and extensibility), (2) hierarchical scheduling and task planning for improved utilization of heterogeneous HW, as well as (3) evaluating this infrastructure on real-world use cases and benchmarks. Our efforts addressing these objectives are balanced across the open-source development of the DAPHNE system, selected foundational research projects for later integration, and a continuous refinement of the use case implementations and benchmarks.