Periodic Reporting for period 1 - XtraUS (Fighting cancer relapse with remote activation of smart and targeted nanoconstructs)
Periodo di rendicontazione: 2021-03-01 al 2022-10-31
The XtraUS project focuses on the prevention of cancer relapse and on the achievement of an early cure of recurrence, thus having a heavy impact on health and on its financial implications. Actually, many patients unfortunately get into a recurrence of their primary tumor disease, since their cancer is not fully remitted and they require further treatment to manage it.
Minimal residual disease (MRD) after potentially curative treatment generally contributes to disease relapse and is the target of early adjuvant treatments. In particular, circulating tumor cells (CTCs) in the blood stream have a key role in cancer progression, recurrence and metastasis spreading. However, their such tiny amount is difficult to detect by conventional laboratory tests. From a social and financial perspective, fighting these cancer cells has a huge impact on cancer relapse prevention and thus on the health, quality of life and overall cancer treatment expenditure.
XtraUS aims at validating a breakthrough technology to fight CTCs and the spread of metastasis in the bloodstream and thus reduce the rise of MRD and further cancer relapse. It applies an extracorporeal blood circulation set-up exploiting a novel stimuli-responsive, targeted and non-immunogenic nanoconstruct, remotely activated against cancer cells. We have currently validated the XtraUS technology in collaboration with hospitals and we are under discussion with a big pharma company, as the treatment is currently being validated as a personalized and translational approach, with high-target specificity and reduced collateral damage to both blood and adjacent healthy tissues. With this technology, we aim to advance the conventional treatments of CTCs in the blood stream and we have discovered new therapeutic possibilities, which are currently under pre-clinical validation using the blood of oncological patients. In particular we aim to propose a more effective and safer treatment to fight cancer relapse and metastasis spreading than the current ones. The driving idea is to render permanent and efficacious the first treatment offered to patients for their primary tumor disease, avoid cancer relapse, and reduce all associated costs.
XtraUS is a versatile technology, with potential applications also on many other diseases, with huge societal and economic impacts on public health.
Minimal residual disease (MRD) after potentially curative treatment generally contributes to disease relapse and is the target of early adjuvant treatments. In particular, circulating tumor cells (CTCs) in the blood stream have a key role in cancer progression, recurrence and metastasis spreading. However, their such tiny amount is difficult to detect by conventional laboratory tests. From a social and financial perspective, fighting these cancer cells has a huge impact on cancer relapse prevention and thus on the health, quality of life and overall cancer treatment expenditure.
XtraUS aims at validating a breakthrough technology to fight CTCs and the spread of metastasis in the bloodstream and thus reduce the rise of MRD and further cancer relapse. It applies an extracorporeal blood circulation set-up exploiting a novel stimuli-responsive, targeted and non-immunogenic nanoconstruct, remotely activated against cancer cells. We have currently validated the XtraUS technology in collaboration with hospitals and we are under discussion with a big pharma company, as the treatment is currently being validated as a personalized and translational approach, with high-target specificity and reduced collateral damage to both blood and adjacent healthy tissues. With this technology, we aim to advance the conventional treatments of CTCs in the blood stream and we have discovered new therapeutic possibilities, which are currently under pre-clinical validation using the blood of oncological patients. In particular we aim to propose a more effective and safer treatment to fight cancer relapse and metastasis spreading than the current ones. The driving idea is to render permanent and efficacious the first treatment offered to patients for their primary tumor disease, avoid cancer relapse, and reduce all associated costs.
XtraUS is a versatile technology, with potential applications also on many other diseases, with huge societal and economic impacts on public health.