Redefining mass spectrometry – a breakthrough platform for real-time noninvasive breath analysis with single ion detection of intact viruses and bacteria and post-analysis molecular characterization

Informations projet

ARIADNE

N° de convention de subvention: 964553

DOI

10.3030/964553

Projet clôturé

Date de signature de la CE 9 Mars 2021

Date de début 1 Juin 2021

Date de fin 31 Mai 2026

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 982 000,00

Contribution de l’UE

€ 3 982 000,00

Coordonné par

FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA
Greece

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (5)

Dissemination & Exploitation plan

Dissemination Exploitation plan Report M6

Single bacterial cell proteomics workflow development

KI will report on the development of single bacterial cell proteomics workflows M12

Development of proteomics workflows for analysing viruses

USIEG will report on the development of proteomics workflows for analysing viruses M12

Dissemination & Exploitation Plan (update)

Update on Dissemination & Exploitation Plan (confirmation that Fasmatech's change of ownership does not affect the Dissemination & Exploitation Plan as it was reported in D7.5)

Advancements in single bacterial cell proteomics workflows

KI will report on advancements in single bacterial cell proteomics workflows M30

Open Research Data Pilot (2)

Data Management Plan (DMP)

Open Research Data Pilot Open Access to Scientific Publications

Data Management Plan (update)

Update on Data Management Plan (confirmation that Fasmatech's change of ownership does not affect DMP as it was reported in D7.4)

Demonstrators, pilots, prototypes (4)

MSn Top-down analysis utilizing the Omnitrap activation network

USIEG /UzL will perform top-down analysis in MSn mode utilizing the omnitrap activation network (M42).

Top-down analysis in the FT-CDMS using CO2 lasers

CNRS will perform top-down analysis in the FT-CDMS using CO2 lasers (M45)

Working system in both transmission and trapping modes

CNRS will demonstrate a working system in both transmission and trapping modes (M18).

Omnitrap platform to USIEG for coupling to the UHMR

FAST will deliver an omnitrap platform to USIEG for coupling to the UHMR (M12).

Websites, patent fillings, videos etc. (2)

Scientific reports and publications

D71 Scientific reports and publications M24

Project logo and website launch and public accessibility

Project logo and website launch and public accessibility M4

Publications

Peer reviewed articles (11)

Solvent-Induced Aggregation of Self-Assembled Copper–Cysteine Nanoparticles Reacted with Glutathione: Enhancing Linear and Nonlinear Optical Properties

Auteurs: Dipankar Bain, Isabelle Russier-Antoine, Hao Yuan, Sarita Kolay, Sylvain Maclot, Christophe Moulin, Estelle Salmon, Pierre-François Brevet, Anna Pniakowska, Joanna Olesiak-Bańska and Rodolphe Antoine
Publié dans: Langmuir 2023, 39, 46, 16554–16561, 2023, ISSN 1520-5827
Éditeur: ACSPublications
DOI: 10.1021/acs.langmuir.3c02526

High-Performance Data Acquisition for Fourier Transform Mass Spectrometry

Auteurs: Anton N. Kozhinov, Konstantin O. Nagornov, Yury O. Tsybin
Publié dans: CHIMIA, Numéro 79, 2025, Page(s) 77-83, ISSN 0009-4293
Éditeur: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2025.77

Nanoelectrospray ionization coupled to a linear charge detection array ion trap spectrometer for single viral particle analysis

Auteurs: S. Maclot, T. Reinert, L. Duplantier, G. Montagne, C. Clavier, X. Dagany, C. Comby-Zerbino, M. Kerleroux, R. Antoine, L. Thiede, R. Pogan, C. Uetrecht, A. N. Kozhinov, K. O. Nagornov, Y. O. Tsybin, D. Papanastasiou
Publié dans: Review of Scientific Instruments, Numéro 96, 2025, ISSN 0034-6748
Éditeur: American Institute of Physics
DOI: 10.1063/5.0283803

Super-Resolution Mass Spectrometry Enables Rapid, Accurate, and Highly Multiplexed Proteomics at the MS2 Level

Auteurs: Anton N. Kozhinov, Alex Johnson, Konstantin O. Nagornov, Michael Stadlmeier, Warham Lance Martin, Loïc Dayon, John Corthésy, Martin Wühr, and Yury O. Tsybin
Publié dans: Analytical Chemistry, 2023, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.2c04742

Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade

Auteurs: Luca Fornelli, Daniel Ayoub, Kristina Srzentic, Konstantin O. Nagornov, Anton N. Kozhinov, Natalia Gasilova, Laure Menin, Alain Beck, Yury O. Tsybin
Publié dans: Chimia, 2022, ISSN 0009-4293
Éditeur: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2022.114

Applying Distinct CDMS Strategies to Observe Nonclassical Virus Capsid Assembly

Auteurs: Lars Thiede, Anisha Haris, Tomislav Damjanović, Jocky C. K. Kung, Jürgen Müller‐Guhl, Ronja Pogan, Jennifer Rothe, Wiebke Schultze, Sanne Ugelstad, David Eatough, Kevin Giles, Steve Preece, Keith Richardson, Jakub Ujma, Charlotte Uetrecht
Publié dans: Journal of Mass Spectrometry, Numéro 61, 2026, ISSN 1076-5174
Éditeur: IM Publications
DOI: 10.1002/jms.70068

From Science to Fiction – Connecting In Vivo and In Vitro Results in Polyprotein Processing of Coronaviruses

Auteurs: Kira Schamoni-Kast, Charlotte Uetrecht
Publié dans: Journal of Molecular Biology, Numéro 437, 2025, Page(s) 169370, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2025.169370

Characterization of Nanoparticles by Taylor Dispersion Analysis Hyphenated to Charge Detection Mass Spectrometry

Auteurs: Tessa Reinert, Séléna Ferreres, Lilou Duplantier, Dipankar Bain, Guillaume Montagne, Sylvain Maclot, Martinus H. V. Werts, Rodolphe Antoine
Publié dans: Analysis & Sensing, Numéro 6, 2026, ISSN 2629-2742
Éditeur: Wiley
DOI: 10.1002/anse.202500245

Toward Single Bacterium Proteomics

Auteurs: Ákos Végvári, Xuepei Zhang, Roman A. Zubarev
Publié dans: J. Am. Soc. Mass Spectrom. 2023, 34, 2098−2106, 2023, ISSN 1044-0305
Éditeur: Elsevier BV
DOI: 10.1021/jasms.3c00242

Charging of Ligand-Protected Gold Nanoparticles in Electrospray Ionization: Probing Ligand Bond Strength by Charge Detection Mass Spectrometry

Auteurs: B. S. Sooraj, Sylvain Maclot, Anagha Jose, Clothilde Comby-Zerbino, Tessa Reinert, Keerthana Unni, Rodolphe Antoine, Thalappil Pradeep
Publié dans: The Journal of Physical Chemistry Letters, Numéro 16, 2025, Page(s) 7004-7011, ISSN 1948-7185
Éditeur: American Chemical Society
DOI: 10.1021/acs.jpclett.5c01075

Collision induced unfolding and molecular dynamics simulations of norovirus capsid dimers reveal strain-specific stability profiles

Auteurs: Maxim N. Brodmerkel, Lars Thiede, Emiliano De Santis, Charlotte Uetrecht, Carl Caleman and Erik G. Marklund
Publié dans: Physical Chemistry Chemical Physics, 2024, ISSN 1463-9076
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3cp06344e

Book chapters (1)

Physical VirologyFrom the State-of-the-Art Research to the Future of Applied VirologyChapter 9Norovirus - A capsid in perpetual flux

Auteurs: Lars Thiede, Ronja Pogan, Charlotte Uetrecht
Publié dans: 2023, ISBN 978-3-031-36814-1
Éditeur: SPRINGER
DOI: 10.1007/978-3-031-36815-8

Non-peer reviewed articles (1)

In Silico Top-Down Fourier Transform Mass Spectra to Advance Proteoform Analysis Methods

Auteurs: Nina A. Khristenko, Konstantin O. Nagornov, Anton N. Kozhinov, David P. A. Kilgour, Yury O. Tsybin
Publié dans: Journal of the American Society for Mass Spectrometry, 2026, ISSN 1044-0305
Éditeur: Elsevier BV
DOI: 10.26434/chemrxiv.15003684/v1