Descripción del proyecto
Una tecnología de imagenología molecular revolucionaria para el centro de asistencia sanitaria
El accidente cerebrovascular es la segunda causa de muerte más común en el mundo y la amplitud del daño isquémico constituye el factor determinante para su tratamiento. La ventana de tiempo para iniciar el tratamiento es muy pequeña, de unas pocas horas, pero los centros de asistencia sanitaria carecen de las técnicas de imagenología moleculares necesarias. Para abordar este problema, el objetivo del proyecto GAMMA-MRI, financiado con fondos europeos, es desarrollar una tecnología de obtención de imágenes revolucionaria que emplea los rayos γ y la resonancia magnética (RM, o MRI por sus siglas en inglés), combinando así lo mejor de estas dos metodologías. Este dispositivo innovador incorpora inteligencia artificial y se espera que mejore la obtención de imágenes moleculares, además de posibilitar el desarrollo del tratamiento temprano personalizado del accidente cerebrovascular.
Objetivo
Gamma-MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon. In the strategic move from “one size fits all” to personalised medicine, molecular imaging plays an essential role. However, despite significant technological advances in the last decades, medical imaging (especially for the brain) relies heavily on very expensive, complex and bulky machines. Moreover, MRI suffers from low sensitivity, only partially compensated by the recent advances in hyperpolarisation. On the other hand, the very sensitive PET and SPECT imaging modalities offer limited spatial resolution. Besides those trade-offs, the limited access to suitable devices still hinders the applicability of medical imaging to address major healthcare challenges in brain-related pathologies, even in Europe. Stroke alone is the second cause of death and the third cause of disability worldwide. The evolution of ischaemic damage varies much among patients. To achieve significant improvement in the outcome of the patients, a careful selection of the treatment path guided by images of the ischaemic brain, in a narrow time window of just a few hours is crucial. Unfortunately, point-of-care molecular imaging that could speed up patient management barely exists. Gamma-MRI is a game-changer imaging technology, combining the high sensitivity of gamma ray detection and the high resolution and flexibility of MRI, bringing down by multiple fold the cost of molecular imaging. Six closely interlinked work packages will cover: production of hyperpolarised gamma-emitting xenon isomers; preserving hyperpolarisation until delivery to targeted organ; developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches; designing and assembling the prototype upon a low field versatile magnet; and implementing the first preclinical Gamma-MRI brain imaging experiment.
Ámbito científico
- natural sciencescomputer and information sciencesartificial intelligence
- natural scienceschemical sciencesinorganic chemistrynoble gases
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesbasic medicineneurologystroke
- engineering and technologymedical engineeringdiagnostic imaging
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-2018-2019-2020-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
2800 Delemont
Suiza