Projektbeschreibung
Eine alles verändernde Technologie zur patientennahen molekularen Bildgebung
Schlaganfälle sind die zweithäufigste Todesursache weltweit. Bei Überlebenden stellt das Ausmaß der ischämischen Schädigung den ausschlaggebenden Behandlungsfaktor dar. Der Behandlungsbeginn muss innerhalb eines sehr engen Zeitfensters von wenigen Stunden erfolgen, doch es fehlt noch an Möglichkeiten zur patientennahen molekularen Bildgebung. Um dieses Problem anzugehen, schlägt das EU-finanzierte Projekt GAMMA-MRI die Entwicklung einer bahnbrechenden Bildgebungstechnologie vor, die Gammastrahlen mithilfe der Magnetresonanztomografie (MRT) manipuliert und somit die Vorzüge dieser beiden Technologien effektiv kombiniert. Dieses neue System, das künstliche Intelligenz einbezieht, wird die molekulare Bildgebung voraussichtlich voranbringen und zugleich die personalisierte Frühbehandlung von Schlaganfällen in greifbarere Nähe rücken.
Ziel
Gamma-MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon. In the strategic move from “one size fits all” to personalised medicine, molecular imaging plays an essential role. However, despite significant technological advances in the last decades, medical imaging (especially for the brain) relies heavily on very expensive, complex and bulky machines. Moreover, MRI suffers from low sensitivity, only partially compensated by the recent advances in hyperpolarisation. On the other hand, the very sensitive PET and SPECT imaging modalities offer limited spatial resolution. Besides those trade-offs, the limited access to suitable devices still hinders the applicability of medical imaging to address major healthcare challenges in brain-related pathologies, even in Europe. Stroke alone is the second cause of death and the third cause of disability worldwide. The evolution of ischaemic damage varies much among patients. To achieve significant improvement in the outcome of the patients, a careful selection of the treatment path guided by images of the ischaemic brain, in a narrow time window of just a few hours is crucial. Unfortunately, point-of-care molecular imaging that could speed up patient management barely exists. Gamma-MRI is a game-changer imaging technology, combining the high sensitivity of gamma ray detection and the high resolution and flexibility of MRI, bringing down by multiple fold the cost of molecular imaging. Six closely interlinked work packages will cover: production of hyperpolarised gamma-emitting xenon isomers; preserving hyperpolarisation until delivery to targeted organ; developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches; designing and assembling the prototype upon a low field versatile magnet; and implementing the first preclinical Gamma-MRI brain imaging experiment.
Wissenschaftliches Gebiet
- natural sciencescomputer and information sciencesartificial intelligence
- natural scienceschemical sciencesinorganic chemistrynoble gases
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesbasic medicineneurologystroke
- engineering and technologymedical engineeringdiagnostic imaging
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenUnterauftrag
H2020-FETOPEN-2018-2019-2020-01
Finanzierungsplan
RIA - Research and Innovation actionKoordinator
2800 Delemont
Schweiz