Continuous two-dimensional Stretch monitoring of fresh tissue Biopsies

Información del proyecto

StretchBio

Identificador del acuerdo de subvención: 964808

DOI

10.3030/964808

Proyecto finalizado el 30 Abril 2026

Fecha de la firma de la CE 8 Marzo 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 31 Mayo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 822 695,00

Aportación de la UE

€ 3 822 695,00

Coordinado por

UNIVERSITAT DE BARCELONA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (15)

Report on the 2nd intermediate Project meeting

Report corresponding to the 2nd intermediate meeting

Report on communication and outreach

Intermediate report on the communication to stakeholders and outreach of the project.

Report on the bending-force relation in nanopillars

Experimental data on the relation deformation-force for the nanopillar sizes and geometries. The report will compare the experimental with those obtained from the simulation (deliverable D2.1).

Guidelines for optimised semiconductor fabrication route

The complete fabrication route for the successful fabrication of the nanopillar arrays of different diameters heights and pitches will be reported

Report on living tissues issues affecting light propagation

Several phenomena can occur during tissue growth, for example, the emission of cilia, that can penetrate into the nanopillar array, affecting light propagation. The impact of this and other phenomena on light transmission will be studied.

Report on dissemination and training actions

The result of the organisation of the workshops and of the dissemination of the initial scientific and technical outcomes of the project will be described.

Report on relation deformation-force for the nanopillars

The report will present the results of the simulated relation between nanopillar deformation and horizontally exerted forces based on finite element modelling. It will report the values corresponding to different nanopillar vertical and radial dimensions, corresponding to the dimensions which can be fabricated. The values will be relevant for selecting the subsequent fabrication processes. Nanopillar horizontal displacements around several tens of nanometre are expected for forces in the range of pico Newton.

Report on photodetector selection and characterisation

Miniaturised photodetectors need to be used to fit to the nanopillar array. Both commercially available as well as ad-hoc designed detector will be and will be either adapted or designed.

Report on the 3rd intermediate Project meeting

Report corresponding to the 3rd intermediate meeting

Report on the 1st intermediate Project meeting

Report corresponding to the 1st intermediate meeting

Kick-off meeting

Kickoff meeting of the project

Report on the design and fabrication issues of the optical grating

Gratings have been selected for coupling the nanopillar chip to the light source and detector The best configurations compatible with the nanofabrication route will be simulated fabricated

Report on the photonic performance of the nanosystem

Initial light transmission measurements for different configurations of defects, including that of the demonstrator delivered in D2.3. The results will prove the feasibility of the measurements upon nanopillar bending.

Report on the nanopillar biocompatibility

Viability tests of the cell survival upon prolonged contact with the nanopillar array will be reported. Results on bare, inorganically and organically functionalised surfaces will be compared, with the aim of achieving biocompatible surfaces.

Dissemination and exploitation plan

Initial dissemination and exploitation plan including patentability study and market prospect

Open Research Data Pilot (1)

Data management plan

Websites, patent fillings, videos etc. (1)

Website

Web domain acquired and initial setup

Publicaciones

Other (9)

D7.3 – REPORT ON THE FIRST INTERMEDIATE PROJECT MEETING

Autores: HERNANDEZ-RAMIREZ, FRANCISCO; ROMANO-RODRIGUEZ, ALBERT
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7015205

D8.1_StretchBio Website initial set-up

Autores: HERNANDEZ-RAMIREZ; ROMANO-RODRIGUEZ
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7015168

StretchBio_D8.2_DISSEMINATION AND EXPLOITATION PLAN

Autores: Alexandre Cabré; Albert Romano-Rodriguez; Francisco Hernández-Ramírez
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7181850

StretchBio_D.4.1_ Report on the nanopillar biocompatibility

Autores: Marta Ollé; Sheila Guisado; Cristiano Pellegrini; Florenci Serras; Albert Romano-Rodriguez; Francisco Hernández-Ramírez; David Rovira; Noemi de Luna
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7149079

D7.1_StretchBio Kick-off Meeting of the Project

Autores: HERNANDEZ-RAMIREZ, FRANCISCO; ROMANO-RODRIGUEZ, ALBERT
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7015132

StretchBio_D.2.1_Report on relation deformation-force for the nanopillars

Autores: Dimaki, Maria; Bertelsen, Christian; Navarro Urrios, Daniel; Moreno Sereno, Mauricio; López Aymerich, Elena; Jaramillo Fernández, Juliana; Romano Rodríguez, Albert; Hernández-Ramírez, Francisco
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.6509544

StretchBio_D.3.1_Guidelines for optimized semiconductor fabrication route

Autores: Lopez, E; Bertelsen, C; HERNANDEZ-RAMIREZ, F; ROMANO-RODRIGUEZ, A
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7015228

D7.2 – DATA MANAGEMENT PLAN

Autores: ROMANO-RODRIGUEZ; HERNANDEZ-RAMIREZ
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7015191

StretchBio_D.5.1_Report on the design and fabrication issues of the optical grating

Autores: Jens Goldschmidt; Katrin Schmitt; Albert Romano-Rodriguez; Francisco Hernández-Ramírez; Elena Lopez-Aymerich; Christian Vinther Bertelsen
Publicado en: 2022
Editor: NA
DOI: 10.5281/zenodo.7181823

Peer reviewed articles (7)

Stromagenesis and cancer‐associated fibroblast heterogeneity in primary tumors and metastasis: focus in non‐small cell lung cancer

Autores: Alejandro Bernardo, Natalia Díaz‐Valdivia, Patricia Fernández‐Nogueira, Jordi Alcaraz
Publicado en: FEBS Open Bio, Edición 15, 2025, Página(s) 1599-1617, ISSN 2211-5463
Editor: Elsevier BV
DOI: 10.1002/2211-5463.70102

Strong Cavity-Optomechanical Transduction of Nanopillar Motion

Autores: Juliana Jaramillo-Fernandez, Martin Poblet, David Alonso-Tomás, Christian Vinther Bertelsen, Elena López-Aymerich, Daniel Arenas-Ortega, Winnie Edith Svendsen, Néstor Capuj, Albert Romano-Rodríguez, Daniel Navarro-Urrios
Publicado en: ACS Nano, Edición 18, 2024, Página(s) 24550-24557, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.4c09014

Enhancing Grayscale E‐Beam Lithography: Thermal Treatment of Novolak‐Based Resist for 3D Nanostructures

Autores: Rahul Singh, Christian Vinther Bertelsen, Neeti Kalyani, Maria Dimaki, Winnie Edith Svendsen
Publicado en: Advanced Materials Interfaces, Edición 13, 2026, ISSN 2196-7350
Editor: Wiley
DOI: 10.1002/admi.202500632

Observation of edge bound states in the continuum at truncated silicon pillar photonic crystal

Autores: Rodrigo Sato, Christian Vinther Bertelsen, Maxim Nikitin, Elena Lopez Aymerich, Radu Malureanu, Winnie Edith Svendsen, Andrei V. Lavrinenko, Osamu Takayama
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-54929-0

Hybrid SiO ₂ /Si pillar‐based optomechanical crystals for on‐chip photonic integration

Autores: Martin Poblet, Christian Vinther Bertelsen, David Alonso‐Tomás, Rahul Singh, Elena López‐Aymerich, Jens Goldschmidt, Katrin Schmitt, Maria Dimaki, Winnie E. Svendsen, Albert Romano‐Rodríguez, Daniel Navarro‐Urrios
Publicado en: Nanophotonics, Edición 14, 2026, Página(s) 2953-2961, ISSN 2192-8614
Editor: Wiley
DOI: 10.1515/nanoph-2025-0232

Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer

Autores: Natalia Díaz-Valdivia, Paula Duch, Rafael Ikemori, Amelia L. Parker, Marselina Arshakyan, Alejandro Llorente, Alejandro Bernardo, José Rodríguez-Rojas, Josep Lluis Carrasco, Danielle Park, Erik Sahai, Cristina Fillat, Manel Juan, Ernest Nadal, Noemí Reguart, Derek C. Radisky, Oriol Casanovas, Jordi Alcaraz
Publicado en: Cell Death & Disease, Edición 17, 2026, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-026-08677-2

Aberrant <scp>TIMP</scp>‐1 production in tumor‐associated fibroblasts drives the selective benefits of nintedanib in lung adenocarcinoma

Autores: Paula Duch; Natalia Díaz‐Valdivia; Marta Gabasa; Rafael Ikemori; Marselina Arshakyan; Patricia Fernández‐Nogueira; Alejandro Llorente; Cristina Teixido; Josep Ramírez; Javier Pereda; Lourdes Chuliá‐Peris; José Marcelo Galbis; Frank Hilberg; Noemí Reguart; Derek C. Radisky; Jordi Alcaraz
Publicado en: Cancer Science, 2024, ISSN 1347-9032
Editor: Oxford University Press
DOI: 10.1111/cas.16141