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Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Objective

The scale of micro- and nanoplastic (MNP) pollution is becoming increasingly clear yet little is known about how this pollution impacts health. The AURORA project will deliver an actionable European roadmap for early-life health risk assessment of MNPs to support regulation of MNPs and the products and processes that generate secondary MNPs, and development of safer alternatives. We will focus on MNP exposures and toxicological and health effects during pregnancy, in utero, and in early life. These periods are critical for development and health later in life and are of heightened vulnerability to environmental insults. We have recently shown that MNPs are likely to cross the placental barrier in vitro and in vivo, underlying the urgent need to understand the impact of MNPs on reproductive and early-life health. AURORA will do so by significantly enhancing exposure assessment capabilities for measuring MNPs and MNP-associated chemicals (e.g. additives) in tissues relevant for early-life development (placenta, cord blood, amniotic fluid, meconium, fetal tissue). It will take a unique approach by combining in-depth characterization methods (microscopy and spectroscopy) and scalable methods (mass-spectrometry) to develop methods for both detailed and large-scale toxicological, exposure assessment, and epidemiological studies. This will be combined with a novel tiered-testing approach and epidemiological investigations to provide the first extensive evaluation of maternal and fetal MNP exposures and health perturbations, including placental function, immune-inflammatory responses, oxidative stress, accelerated aging, endocrine disruption, and child development. In the course of developing and applying the tools and methodological workflows of the AURORA research program, we will create a risk assessment framework specific to MNPs and identify the remaining knowledge gaps and priorities needed for comprehensively evaluating the impact of MNPs on early-life health. AURORA is part of the European MNP cluster on human health.

Field of science

  • /natural sciences/earth and related environmental sciences/environmental sciences/pollution
  • /medical and health sciences/clinical medicine/obstetrics and gynaecology/obstetrics

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 170 413,75

Participants (10)

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain
EU contribution
€ 310 703,75
Address
C Rossello 132 Planta 05
08036 Barcelona
Activity type
Research Organisations
UNIVERSITEIT HASSELT
Belgium
EU contribution
€ 454 908,75
Address
Martelarenlaan 42
3500 Hasselt
Activity type
Higher or Secondary Education Establishments
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
EU contribution
€ 1 094 770
Address
One Gustave L Levy Place Box 1075
10029 6574 New York
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 1 127 015
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Masarykova univerzita
Czechia
EU contribution
€ 272 312,50
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 564 977,50
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 335 070
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
FOOD PACKAGING FORUM FOUNDATION
Switzerland
EU contribution
€ 379 062,50
Address
Staffelstrasse 10
8045 Zurich
Activity type
Other
INSTITUTE OF OCCUPATIONAL MEDICINE
United Kingdom
EU contribution
€ 208 550
Address
Research Avenue North, Riccarton 45
EH14 4AP Edinburgh
Activity type
Research Organisations
CARL VON OSSIETZKY UNIVERSITAET OLDENBURG
Germany
EU contribution
€ 78 531,25
Address
Ammerlaender Heerstrasse 114-118
26129 Oldenburg
Activity type
Higher or Secondary Education Establishments