Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Project Information

AURORA

Grant agreement ID: 964827

DOI

10.3030/964827

EC signature date 2 February 2021

Start date 1 April 2021

End date 30 September 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 996 315,00

EU contribution

€ 5 996 315,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

HRMS profiling of placenta or cord blood metabolome

Report describing the results of the HRMS analyses on biological samples from the BISC and Environage cohort.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Demonstrators, pilots, prototypes (1)

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Websites, patent fillings, videos etc. (1)

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Publications

Peer reviewed articles (8)

Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Author(s): Jesus Pujol, Laura Blanco-Hinojo, Cecilia Persavento, Gerard Martínez-Vilavella, Carles Falcón, Mireia Gascón, Ioar Rivas, Marc Vilanova, Joan Deus, Juan Domingo Gispert, Maria Dolors Gómez-Roig, Elisa Llurba, Payam Dadvand, Jordi Sunyer
Published in: NeuroImage, Issue 298, 2025, Page(s) 120780, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2024.120780

Development of a reliable preprocessing protocol for fluorescent micro- and nanoplastic analysis in human placental tissue

Author(s): Laura M Zoutendijk, Zenzi Matla, Hanna M Dusza, Barbara M Scholz-Böttcher, Bert M Weckhuysen, Laurens D B Mandemaker, Florian Meirer
Published in: Environmental Toxicology and Chemistry, Issue 44, 2025, Page(s) 2818-2831, ISSN 0730-7268
Publisher: Society of Environmental Toxicology and Chemistry
DOI: 10.1093/etojnl/vgaf177

Air pollution and fetal brain morphological development: a prospective cohort study

Author(s): Laura Gómez-Herrera, Yu Zhao, Ioar Rivas, Elisenda Eixarch, Carla Domínguez-Gallardo, Toni Galmes, Marta Muniesa, Maria Julia Zanini, Alan Domínguez, Marta Cirach, Mark Nieuwenhuijsen, Xavier Basagaña, Xavier Querol, Maria Foraster, Mariona Bustamante, Jesus Pujol, Mireia Gascon, Elisa Llurba, María Dolores Gómez-Roig, Payam Dadvand, Jordi Sunyer
Published in: The Lancet Planetary Health, Issue 9, 2025, Page(s) e480-e490, ISSN 2542-5196
Publisher: Elsevier BV
DOI: 10.1016/s2542-5196(25)00093-2

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies

Author(s): Kuanliang Shao, Runyu Zou, Zhuoyue Zhang, Laurens D.B. Mandemaker, Sarah Timbie, Ronald D. Smith, Amanda M. Durkin, Hanna M. Dusza, Florian Meirer, Bert M. Weckhuysen, Tanya L. Alderete, Roel Vermuelen, Douglas I. Walker
Published in: Annual Review of Pharmacology and Toxicology, Issue 65, 2025, Page(s) 567-585, ISSN 0362-1642
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-030424-112828

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Author(s): Chijioke Olisah, Lisa Melymuk, Ondrej Audy, Petr Kukucka, Petra Pribylova, Martin Boudot
Published in: Environmental Sciences Europe, Issue 36, 2024, ISSN 2190-4715
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s12302-024-00999-2

Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study

Author(s): Amanda M Durkin, Runyu Zou, Justin M Boucher, Matthew SP Boyles, Jeske van Boxel, Mariona Bustamante, Emily A Christopher, Payam Dadvand, Hanna M Dusza, Majorie van Duursen, Markus M Forsberg, Karen S Galea, Juliette Legler, Laurens DB Mandemaker, Florian Meirer, Jane Muncke, Tim S Nawrot, Petra Přibylová, Anna R Robuck, Nelly D Saenen, Barbara M Scholz-Böttcher, Kuanliang Shao, Martine Vrijhei
Published in: JMIR Research Protocols, Issue 13, 2024, Page(s) e63176, ISSN 1929-0748
Publisher: JMIR Publications Inc.
DOI: 10.2196/63176

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Author(s): Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Published in: Journal of Exposure Science & Environmental Epidemiology, Issue 34, 2024, Page(s) 90-96, ISSN 1559-0631
Publisher: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

Interlaboratory Comparison Reveals State of the Art in Microplastic Detection and Quantification Methods

Author(s): Dmitri Ciornii, Vasile-Dan Hodoroaba, Nizar Benismail, Alina Maltseva, Juan F. Ferrer, Jiamin Wang, Raquel Parra, Ronan Jézéquel, Justine Receveur, Dina Gabriel, Andreas Scheitler, Christa van Oversteeg, Jorg Roosma, Alex van Renesse van Duivenbode, Tim Bulters, Michela Zanella, Alessandro Perini, Federico Benetti, Dora Mehn, Georg Dierkes, Michael Soll, Takahisa Ishimura, Marius Bednarz, Guyu P
Published in: Analytical Chemistry, Issue 97, 2025, Page(s) 8719-8728, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.4c05403

Other (8)

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Author(s): Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Published in: Elsevier ScienceDirect, Issue volume 860, 20 february 2023, 2023, Page(s) 160403
Publisher: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Author(s): Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Published in: online: https://zenodo.org/records/7968133 - online brochure/poster, Issue May 25, 2023 - v1, 2023
Publisher: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

PlasticsFatE Deliverable Report D7.6 Cluster Brochure

Author(s): Tobin, Lesley; Kienzl, Sabine; Mata, Virginia; Vivani, Laura; Muncke, Jane; Boucher, Justin
Published in: PlasticsFatE Deliverable Report D7.6 Cluster Brochure, Issue 6, 2023
Publisher: Zenodo
DOI: 10.5281/zenodo.8092258

PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1

Author(s): Foss Hansen, Stephen; Hernandez, Alba
Published in: PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1, Issue 6, 2023
Publisher: Zenodo
DOI: 10.5281/zenodo.8092278

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Author(s): Laurens D. B. Mandemaker; Florian Meirer
Published in: Angewandte Chemie - International Edition, Issue October 24, 2022, 2022
Publisher: Wiley-Blackwell
DOI: 10.1002/anie.202210494

PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity

Author(s): Tobin, Lesley; Muncke, Jane; Vivani, Laura; Kienzl, Sabine; Mata Marcano, Virginia; Steinbach, Christoph; Roordink, Danielle; Boucher, Justin
Published in: PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity, Issue 6, 2023
Publisher: Zenodo
DOI: 10.5281/zenodo.8092193

Impacts of micro- and nanoplastics on early-life health

Author(s): Christopher, Emily A.; Christopher-de Vries, Yvette; Devadoss, Anitha; Mandemaker, Laurens D.B.; van Boxel, Jeske; Copsey, Helena M.; Dusza, Hanna M.; Legler, Juliette; Meirer, Florian; Muncke, Jane; Nawrot, Tim S.; Saenen, Nelly D.; Scholz-Böttcher, Barbara M.; Tran, Lang; Weckhuysen, Bert M.; Zou, Runyu; Zimmermann, Lisa; Galea, Karen S.; Vermeulen, Roel; Boyles, Matthew S.P.
Published in: Microplastics and Nanoplastics, Issue 2, 2024
Publisher: Springer Open
DOI: 10.1186/s43591-024-00089-3

CUSP Brochure

Author(s): CUSP
Published in: ZENODO, Issue January 12, 2022, 2022
Publisher: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

Conference proceedings (1)

Sample Pre-processing Protocols for the (Spectro-)Microscopic Analysis of Micro- & Nanoplastics (MNPs) in Maternal and Fetal Tissues

Author(s): Zoutendijk, Laura M.; Mandemaker, Laurens D. B.; Matla, Zenzi; Zimmermann, Lisa; van Dalen, Lonneke; Weckhuysen, Bert M.; Meirer, Florian
Published in: Issue 1, 2023
Publisher: Zenodo
DOI: 10.5281/zenodo.7967295