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CORDIS - Resultados de investigaciones de la UE
CORDIS

NEutron Capture-enhanced Treatment of neurotoxic Amyloid aggRegates

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Secondary IRs production report (se abrirá en una nueva ventana)

Report dealing with the Monte Carlo modelization by Geant4-DNA of the secondary ionizing radiations produced after the neutron capture reactions on Gd157 and B10

Report on dissemination activities (se abrirá en una nueva ventana)

Report summing up the several dissemination activities performed during NECTAR by all the members of the consortium

Scientific Advisory Board (SAB) report (se abrirá en una nueva ventana)

Report by the Scientific Advisory Board (SAB) regarding project achievements and progression

SAB report, end of project (se abrirá en una nueva ventana)

Report of the Scientific Advisory Board meeting for project ending

Financial report, year 3 (se abrirá en una nueva ventana)

Financial report dealing with the activities carried out during the 3rd year of project

Report on in vivo toxicity of CENI (se abrirá en una nueva ventana)

Report dealing with the results obtained in small animals (healthy and transgenic AD mice) after CENI to assess safety/toxicity of the treatment delivered following different protocols.

Financial report, year 1 (se abrirá en una nueva ventana)

Financial report dealing with the activities carried out during the 1st year of project

middle term plan for the dissemination and exploitation of results (se abrirá en una nueva ventana)

Updated interim report dealing with the dissemination including communication activities and exploitation plan

Financial report, end of project (se abrirá en una nueva ventana)

Financial report summing up the activities of the full project

Initial plan for the dissemination and exploitation of results (se abrirá en una nueva ventana)

Report describing the dissemination including communication activities and exploitation plan

Financial report, year 2 (se abrirá en una nueva ventana)

Financial report dealing with the activities carried out during the 2nd year of project

Report on in vitro toxicity of CENI (se abrirá en una nueva ventana)

Report dealing with the results obtained on brain cell cultures of the safety/toxicity of CENI.

Geant4 application delivery for CENI calculation (se abrirá en una nueva ventana)

Geant4 subroutines specifically developed to address CENI physics, chemistry and dosimetry

Project website and logo (se abrirá en una nueva ventana)

Building and publication on line of NECTAR official website which will be kept updated thanks to the participation of all consortium members throughout the whole project duration

Training course and dedicated school, end of project term (se abrirá en una nueva ventana)

Organisation, publicity and implementation of the second and last training course/international school on the topics studied and developed by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Training course and dedicated school, middle project term (se abrirá en una nueva ventana)

Organisation, publicity and implementation of the first training course/international school on the topics addressed and under development by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

First data sharing for the Open Research Data Pilot (se abrirá en una nueva ventana)

free on-line publication (through the project web-site) of the data dealing with CENI agents characterisation, CENI agents binding and distribution on Abeta aggregates, micro and nano-dosimetry, B and Gd concentration measurements. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Second data sharing for the Open Research Data Pilot (se abrirá en una nueva ventana)

free on-line publication (through the project web-site) of the data dealing with: the first tests using the new neutron spectrometer and dosimeter, the new miniaturised dosimeters, the residual neurotoxicity of Abeta aggregates, the in vitro and in vivo toxicity of CENI. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Third data sharing for the Open Research Data Pilot (se abrirá en una nueva ventana)

free on-line publication (through the project web-site) of the data dealing with in vivo CENI efficacy. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Publicaciones

Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis (se abrirá en una nueva ventana)

Autores: Mostafa Karimi Roshan, Sergey Belikov, Melissa Ix, Nicoletta Protti, Claudia Balducci, Richard Dodel, J. Alexander Ross, Lovisa Lundholm
Publicado en: Frontiers in Cellular Neuroscience, Edición 18, 2024, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1440559

Numerical tools for simulating low-energy electron interactions in experimental nanodosimetry applications (se abrirá en una nueva ventana)

Autores: C. Caprioli, D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, N. Protti
Publicado en: Radiation Measurements, Edición 177, 2024, Página(s) 107265, ISSN 1350-4487
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.radmeas.2024.107265

Capture‐enhanced neutron irradiation to treat Alzheimer's disease: Design of a small animal set‐up for future in‐vivo experiments (se abrirá en una nueva ventana)

Autores: Valeria Pascali, Davide Tosoni, Saverio Altieri, Nicoletta Protti
Publicado en: Medical Physics, Edición 52, 2025, ISSN 0094-2405
Editor: American Association of Physicists in Medicine
DOI: 10.1002/mp.18062

Carboranes meet photochemistry: Recent progresses in light-mediated cage functionalisation (se abrirá en una nueva ventana)

Autores: Alberto Lanfranco, Polyssena Renzi, Marco Rusconi, Annamaria Deagostino
Publicado en: Tetrahedron Letters, Edición 131, 2025, Página(s) 154782, ISSN 0040-4039
Editor: Elsevier BV
DOI: 10.1016/j.tetlet.2023.154782

Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples (se abrirá en una nueva ventana)

Autores: D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, S. Pasquato, C. Caprioli, S. Micocci, S. Parisotto, A. Deagostino, S. Geninatti Crich, S. Altieri, N. Protti
Publicado en: Radiation Physics and Chemistry, Edición 222, 2025, Página(s) 111799, ISSN 0969-806X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.radphyschem.2024.111799

The Detection of Toxic Amyloid-β Fibril Fragments Through a Surface Plasmon Resonance Immunoassay (se abrirá en una nueva ventana)

Autores: Marten Beeg, Beatrice Rocutto, Elisabetta Battocchio, Letizia Dacomo, Alessandro Corbelli, Fabio Fiordaliso, Claudia Balducci, Marco Gobbi
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 13020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313020

Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by <sup>19</sup>F-MRI (se abrirá en una nueva ventana)

Autores: Sebastiano Micocci, Rachele Stefania, Francesca Garello, Umberto Fasoglio, Ivan Hawala, Lorenzo Tei, Simonetta Geninatti Crich, Giuseppe Digilio
Publicado en: Organic &amp; Biomolecular Chemistry, Edición 22, 2024, Página(s) 5948-5959, ISSN 1477-0520
Editor: Royal Society of Chemistry
DOI: 10.1039/d4ob00730a

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