NEutron Capture-enhanced Treatment of neurotoxic Amyloid aggRegates

Informazioni relative al progetto

NECTAR

ID dell’accordo di sovvenzione: 964934

DOI

10.3030/964934

Progetto chiuso

Data della firma CE 20 Gennaio 2021

Data di avvio 1 Aprile 2021

Data di completamento 30 Settembre 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 3 217 278,76

Contributo UE

€ 3 137 562,50

Coordinato da

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (12)

Secondary IRs production report

Report dealing with the Monte Carlo modelization by Geant4-DNA of the secondary ionizing radiations produced after the neutron capture reactions on Gd157 and B10

Report on dissemination activities

Report summing up the several dissemination activities performed during NECTAR by all the members of the consortium

Scientific Advisory Board (SAB) report

Report by the Scientific Advisory Board (SAB) regarding project achievements and progression

SAB report, end of project

Report of the Scientific Advisory Board meeting for project ending

Financial report, year 3

Financial report dealing with the activities carried out during the 3rd year of project

Report on in vivo toxicity of CENI

Report dealing with the results obtained in small animals (healthy and transgenic AD mice) after CENI to assess safety/toxicity of the treatment delivered following different protocols.

Financial report, year 1

Financial report dealing with the activities carried out during the 1st year of project

middle term plan for the dissemination and exploitation of results

Updated interim report dealing with the dissemination including communication activities and exploitation plan

Financial report, end of project

Financial report summing up the activities of the full project

Initial plan for the dissemination and exploitation of results

Report describing the dissemination including communication activities and exploitation plan

Financial report, year 2

Financial report dealing with the activities carried out during the 2nd year of project

Report on in vitro toxicity of CENI

Report dealing with the results obtained on brain cell cultures of the safety/toxicity of CENI.

Other (1)

Geant4 application delivery for CENI calculation

Geant4 subroutines specifically developed to address CENI physics, chemistry and dosimetry

Websites, patent fillings, videos etc. (3)

Project website and logo

Building and publication on line of NECTAR official website which will be kept updated thanks to the participation of all consortium members throughout the whole project duration

Training course and dedicated school, end of project term

Organisation, publicity and implementation of the second and last training course/international school on the topics studied and developed by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Training course and dedicated school, middle project term

Organisation, publicity and implementation of the first training course/international school on the topics addressed and under development by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Open Research Data Pilot (3)

First data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with CENI agents characterisation, CENI agents binding and distribution on Abeta aggregates, micro and nano-dosimetry, B and Gd concentration measurements. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Second data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with: the first tests using the new neutron spectrometer and dosimeter, the new miniaturised dosimeters, the residual neurotoxicity of Abeta aggregates, the in vitro and in vivo toxicity of CENI. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Third data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with in vivo CENI efficacy. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Pubblicazioni

Peer reviewed articles (7)

Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis

Autori: Mostafa Karimi Roshan, Sergey Belikov, Melissa Ix, Nicoletta Protti, Claudia Balducci, Richard Dodel, J. Alexander Ross, Lovisa Lundholm
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 18, 2024, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1440559

Numerical tools for simulating low-energy electron interactions in experimental nanodosimetry applications

Autori: C. Caprioli, D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, N. Protti
Pubblicato in: Radiation Measurements, Numero 177, 2024, Pagina/e 107265, ISSN 1350-4487
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.radmeas.2024.107265

Capture‐enhanced neutron irradiation to treat Alzheimer's disease: Design of a small animal set‐up for future in‐vivo experiments

Autori: Valeria Pascali, Davide Tosoni, Saverio Altieri, Nicoletta Protti
Pubblicato in: Medical Physics, Numero 52, 2025, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.18062

Carboranes meet photochemistry: Recent progresses in light-mediated cage functionalisation

Autori: Alberto Lanfranco, Polyssena Renzi, Marco Rusconi, Annamaria Deagostino
Pubblicato in: Tetrahedron Letters, Numero 131, 2025, Pagina/e 154782, ISSN 0040-4039
Editore: Elsevier BV
DOI: 10.1016/j.tetlet.2023.154782

Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples

Autori: D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, S. Pasquato, C. Caprioli, S. Micocci, S. Parisotto, A. Deagostino, S. Geninatti Crich, S. Altieri, N. Protti
Pubblicato in: Radiation Physics and Chemistry, Numero 222, 2025, Pagina/e 111799, ISSN 0969-806X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.radphyschem.2024.111799

The Detection of Toxic Amyloid-β Fibril Fragments Through a Surface Plasmon Resonance Immunoassay

Autori: Marten Beeg, Beatrice Rocutto, Elisabetta Battocchio, Letizia Dacomo, Alessandro Corbelli, Fabio Fiordaliso, Claudia Balducci, Marco Gobbi
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2025, Pagina/e 13020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313020

Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by ¹⁹F-MRI

Autori: Sebastiano Micocci, Rachele Stefania, Francesca Garello, Umberto Fasoglio, Ivan Hawala, Lorenzo Tei, Simonetta Geninatti Crich, Giuseppe Digilio
Pubblicato in: Organic & Biomolecular Chemistry, Numero 22, 2024, Pagina/e 5948-5959, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d4ob00730a