NEutron Capture-enhanced Treatment of neurotoxic Amyloid aggRegates

Projektinformationen

NECTAR

ID Finanzhilfevereinbarung: 964934

DOI

10.3030/964934

Projekt abgeschlossen

EK-Unterschriftsdatum 20 Januar 2021

Startdatum 1 April 2021

Enddatum 30 September 2025

Finanziert unter

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Gesamtkosten

€ 3 217 278,76

EU-Beitrag

€ 3 137 562,50

Koordiniert durch

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (12)

Secondary IRs production report

Report dealing with the Monte Carlo modelization by Geant4-DNA of the secondary ionizing radiations produced after the neutron capture reactions on Gd157 and B10

Report on dissemination activities

Report summing up the several dissemination activities performed during NECTAR by all the members of the consortium

Scientific Advisory Board (SAB) report

Report by the Scientific Advisory Board (SAB) regarding project achievements and progression

SAB report, end of project

Report of the Scientific Advisory Board meeting for project ending

Financial report, year 3

Financial report dealing with the activities carried out during the 3rd year of project

Report on in vivo toxicity of CENI

Report dealing with the results obtained in small animals (healthy and transgenic AD mice) after CENI to assess safety/toxicity of the treatment delivered following different protocols.

Financial report, year 1

Financial report dealing with the activities carried out during the 1st year of project

middle term plan for the dissemination and exploitation of results

Updated interim report dealing with the dissemination including communication activities and exploitation plan

Financial report, end of project

Financial report summing up the activities of the full project

Initial plan for the dissemination and exploitation of results

Report describing the dissemination including communication activities and exploitation plan

Financial report, year 2

Financial report dealing with the activities carried out during the 2nd year of project

Report on in vitro toxicity of CENI

Report dealing with the results obtained on brain cell cultures of the safety/toxicity of CENI.

Other (1)

Geant4 application delivery for CENI calculation

Geant4 subroutines specifically developed to address CENI physics, chemistry and dosimetry

Websites, patent fillings, videos etc. (3)

Project website and logo

Building and publication on line of NECTAR official website which will be kept updated thanks to the participation of all consortium members throughout the whole project duration

Training course and dedicated school, end of project term

Organisation, publicity and implementation of the second and last training course/international school on the topics studied and developed by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Training course and dedicated school, middle project term

Organisation, publicity and implementation of the first training course/international school on the topics addressed and under development by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Open Research Data Pilot (3)

First data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with CENI agents characterisation, CENI agents binding and distribution on Abeta aggregates, micro and nano-dosimetry, B and Gd concentration measurements. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Second data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with: the first tests using the new neutron spectrometer and dosimeter, the new miniaturised dosimeters, the residual neurotoxicity of Abeta aggregates, the in vitro and in vivo toxicity of CENI. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Third data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with in vivo CENI efficacy. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Veröffentlichungen

Peer reviewed articles (7)

Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis

Autoren: Mostafa Karimi Roshan, Sergey Belikov, Melissa Ix, Nicoletta Protti, Claudia Balducci, Richard Dodel, J. Alexander Ross, Lovisa Lundholm
Veröffentlicht in: Frontiers in Cellular Neuroscience, Ausgabe 18, 2024, ISSN 1662-5102
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1440559

Numerical tools for simulating low-energy electron interactions in experimental nanodosimetry applications

Autoren: C. Caprioli, D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, N. Protti
Veröffentlicht in: Radiation Measurements, Ausgabe 177, 2024, Seite(n) 107265, ISSN 1350-4487
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.radmeas.2024.107265

Capture‐enhanced neutron irradiation to treat Alzheimer's disease: Design of a small animal set‐up for future in‐vivo experiments

Autoren: Valeria Pascali, Davide Tosoni, Saverio Altieri, Nicoletta Protti
Veröffentlicht in: Medical Physics, Ausgabe 52, 2025, ISSN 0094-2405
Herausgeber: American Association of Physicists in Medicine
DOI: 10.1002/mp.18062

Carboranes meet photochemistry: Recent progresses in light-mediated cage functionalisation

Autoren: Alberto Lanfranco, Polyssena Renzi, Marco Rusconi, Annamaria Deagostino
Veröffentlicht in: Tetrahedron Letters, Ausgabe 131, 2025, Seite(n) 154782, ISSN 0040-4039
Herausgeber: Elsevier BV
DOI: 10.1016/j.tetlet.2023.154782

Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples

Autoren: D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, S. Pasquato, C. Caprioli, S. Micocci, S. Parisotto, A. Deagostino, S. Geninatti Crich, S. Altieri, N. Protti
Veröffentlicht in: Radiation Physics and Chemistry, Ausgabe 222, 2025, Seite(n) 111799, ISSN 0969-806X
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.radphyschem.2024.111799

The Detection of Toxic Amyloid-β Fibril Fragments Through a Surface Plasmon Resonance Immunoassay

Autoren: Marten Beeg, Beatrice Rocutto, Elisabetta Battocchio, Letizia Dacomo, Alessandro Corbelli, Fabio Fiordaliso, Claudia Balducci, Marco Gobbi
Veröffentlicht in: International Journal of Molecular Sciences, Ausgabe 25, 2025, Seite(n) 13020, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313020

Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by ¹⁹F-MRI

Autoren: Sebastiano Micocci, Rachele Stefania, Francesca Garello, Umberto Fasoglio, Ivan Hawala, Lorenzo Tei, Simonetta Geninatti Crich, Giuseppe Digilio
Veröffentlicht in: Organic & Biomolecular Chemistry, Ausgabe 22, 2024, Seite(n) 5948-5959, ISSN 1477-0520
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d4ob00730a