NEutron Capture-enhanced Treatment of neurotoxic Amyloid aggRegates

Informations projet

NECTAR

N° de convention de subvention: 964934

DOI

10.3030/964934

Projet clôturé

Date de signature de la CE 20 Janvier 2021

Date de début 1 Avril 2021

Date de fin 30 Septembre 2025

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 217 278,76

Contribution de l’UE

€ 3 137 562,50

Coordonné par

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (12)

Secondary IRs production report

Report dealing with the Monte Carlo modelization by Geant4-DNA of the secondary ionizing radiations produced after the neutron capture reactions on Gd157 and B10

Report on dissemination activities

Report summing up the several dissemination activities performed during NECTAR by all the members of the consortium

Scientific Advisory Board (SAB) report

Report by the Scientific Advisory Board (SAB) regarding project achievements and progression

SAB report, end of project

Report of the Scientific Advisory Board meeting for project ending

Financial report, year 3

Financial report dealing with the activities carried out during the 3rd year of project

Report on in vivo toxicity of CENI

Report dealing with the results obtained in small animals (healthy and transgenic AD mice) after CENI to assess safety/toxicity of the treatment delivered following different protocols.

Financial report, year 1

Financial report dealing with the activities carried out during the 1st year of project

middle term plan for the dissemination and exploitation of results

Updated interim report dealing with the dissemination including communication activities and exploitation plan

Financial report, end of project

Financial report summing up the activities of the full project

Initial plan for the dissemination and exploitation of results

Report describing the dissemination including communication activities and exploitation plan

Financial report, year 2

Financial report dealing with the activities carried out during the 2nd year of project

Report on in vitro toxicity of CENI

Report dealing with the results obtained on brain cell cultures of the safety/toxicity of CENI.

Other (1)

Geant4 application delivery for CENI calculation

Geant4 subroutines specifically developed to address CENI physics, chemistry and dosimetry

Websites, patent fillings, videos etc. (3)

Project website and logo

Building and publication on line of NECTAR official website which will be kept updated thanks to the participation of all consortium members throughout the whole project duration

Training course and dedicated school, end of project term

Organisation, publicity and implementation of the second and last training course/international school on the topics studied and developed by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Training course and dedicated school, middle project term

Organisation, publicity and implementation of the first training course/international school on the topics addressed and under development by NECTAR. Principal participant targets: PhD student, Post Doc Fellows, Researchers, experienced Professionals (in particular in the medical fields, such as radiotherapists, neurologists, AD MD, AD dedicated nurses...).

Open Research Data Pilot (3)

First data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with CENI agents characterisation, CENI agents binding and distribution on Abeta aggregates, micro and nano-dosimetry, B and Gd concentration measurements. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Second data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with: the first tests using the new neutron spectrometer and dosimeter, the new miniaturised dosimeters, the residual neurotoxicity of Abeta aggregates, the in vitro and in vivo toxicity of CENI. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Third data sharing for the Open Research Data Pilot

free on-line publication (through the project web-site) of the data dealing with in vivo CENI efficacy. The consortium as a whole will decide which data will be published taking into account the potential link to patents.

Publications

Peer reviewed articles (7)

Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis

Auteurs: Mostafa Karimi Roshan, Sergey Belikov, Melissa Ix, Nicoletta Protti, Claudia Balducci, Richard Dodel, J. Alexander Ross, Lovisa Lundholm
Publié dans: Frontiers in Cellular Neuroscience, Numéro 18, 2024, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1440559

Numerical tools for simulating low-energy electron interactions in experimental nanodosimetry applications

Auteurs: C. Caprioli, D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, N. Protti
Publié dans: Radiation Measurements, Numéro 177, 2024, Page(s) 107265, ISSN 1350-4487
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.radmeas.2024.107265

Capture‐enhanced neutron irradiation to treat Alzheimer's disease: Design of a small animal set‐up for future in‐vivo experiments

Auteurs: Valeria Pascali, Davide Tosoni, Saverio Altieri, Nicoletta Protti
Publié dans: Medical Physics, Numéro 52, 2025, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.18062

Carboranes meet photochemistry: Recent progresses in light-mediated cage functionalisation

Auteurs: Alberto Lanfranco, Polyssena Renzi, Marco Rusconi, Annamaria Deagostino
Publié dans: Tetrahedron Letters, Numéro 131, 2025, Page(s) 154782, ISSN 0040-4039
Éditeur: Elsevier BV
DOI: 10.1016/j.tetlet.2023.154782

Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples

Auteurs: D. Mazzucconi, D. Bortot, S. Agosteo, A. Pola, D. Rastelli, S. Pasquato, C. Caprioli, S. Micocci, S. Parisotto, A. Deagostino, S. Geninatti Crich, S. Altieri, N. Protti
Publié dans: Radiation Physics and Chemistry, Numéro 222, 2025, Page(s) 111799, ISSN 0969-806X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.radphyschem.2024.111799

The Detection of Toxic Amyloid-β Fibril Fragments Through a Surface Plasmon Resonance Immunoassay

Auteurs: Marten Beeg, Beatrice Rocutto, Elisabetta Battocchio, Letizia Dacomo, Alessandro Corbelli, Fabio Fiordaliso, Claudia Balducci, Marco Gobbi
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2025, Page(s) 13020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313020

Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by ¹⁹F-MRI

Auteurs: Sebastiano Micocci, Rachele Stefania, Francesca Garello, Umberto Fasoglio, Ivan Hawala, Lorenzo Tei, Simonetta Geninatti Crich, Giuseppe Digilio
Publié dans: Organic & Biomolecular Chemistry, Numéro 22, 2024, Page(s) 5948-5959, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4ob00730a