Objective
Atrial fibrillation (AF) and stroke are major health care problems in Europe. They are most often the clinical expression of atrial cardiomyopathy, which is under-recognised due to the lack of specific diagnostic tools. Multidisciplinary research and stratified approaches are urgently needed to prevent, diagnose, and treat AF and stroke and preempt the AF-related threat to healthy ageing in Europe. MAESTRIA is a European consortium of 18 clinicians, scientists and Pharma industrials who are at the forefront of research and medical care of AF and stroke patients. It will create multi-parametric digital tools based on a new generation of biomarkers that integrate artificial intelligence (AI) processing and big data from cutting edge imaging, electrocardiography and omics technologies. It will develop novel biomarkers, diagnostic tools and personalized therapies for atrial cardiomyopathy. Digital Twin technologies, a rich data integrator combining biophysics and AI will be used to generate virtual twins of the human atria using patient-specific data. Unique experimental large-animal models, ongoing patient cohorts and a prospective MAESTRIA cohort of patients will provide rigorous validation for new biomarkers and newly developed tools. A dedicated core lab will collect and homogenize clinical data. MAESTRIA will be organized as a user-centered platform, easily accessible via clinical parameters routinely used in European hospitals. A Scientific Advisory Board comprising potential clinician users will help MAESTRIA meet clinical and market needs. Dissemination and visibility of the MAESTRIA consortium mission will benefit from participation of the German Competence Network on Atrial Fibrillation (AFNET), and support from the European Society of Cardiology, clinicians, scientists, and other professional societies. MAESTRIA will be ready to tackle the major challenges of data integration and personalized medicine focused on atrial cardiomyopathy, AF and stroke.
Field of science
- /medical and health sciences/basic medicine/neurology/stroke
- /natural sciences/computer and information sciences/artificial intelligence
- /natural sciences/computer and information sciences/data science/big data
Programme(s)
Call for proposal
H2020-SC1-2020-Single-Stage-RTD
See other projects for this call
Funding Scheme
RIA - Research and Innovation actionCoordinator
75006 Paris
France
Participants (17)
75000 Paris
OX1 2JD Oxford
B15 2TT Birmingham
48149 Muenster
45147 Essen
6200 MD Maastricht
10561 Athina
28029 Madrid
02114 Boston Ma
75015 Paris
J1J 3H5 Sherbrooke
91052 Erlangen
OX2 0HP Oxford
75010 Paris
28002 Madrid
07743 Jena
6229 EV Maastricht