Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

MRI-HiRA 1st study subject approvals package
Authorisations for hosting data from related databases, regulatory and Ethical aspects

Authorisations for hosting data from related databases regulatory and Ethical aspects

MAESTRIA AF Ablation mid-term recruitment report
Project management handbook
Report on the feasibility and legal aspects of aggregating health data from different countries
SOPs for ECG, echocardiography, MRI and CT imaging acquisition, processing and storage of whole blood, EDTA plasma, SST serum

SOPs for ECG echocardiography MRI and CT imaging acquisition processing and storage of whole blood EDTA plasma SST serum

CATS-AF mid-term recruitment report
MRI-HiRA report on status of posting results
MAESTRIA AF Ablation 1st study subject approvals package
MAESTRIA-AFNET 10 1st study subject approvals package

MAESTRIAAFNET 10 1st study subject approvals package

MAESTRIA-AFNET 10 mid-term recruitment report
MRI-HiRA mid-term recruitment report
Detailed dissemination plan
CATS-AF 1st study subject approvals package

CATSAF 1st study subject approvals package

Demonstrable prototype of Patient-specific Digital Twin of the atria

Publications

Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial

Author(s): Dipak Kotecha, Karina V. Bunting, Samir Mehta, Philipp Sommer, Maciej Sterliński, Kim Rajappan, Lluís Mont, Eduard Guasch, Serge Boveda, Giuseppe Boriani, Yongzhong Sun, Colinda van Deutekom, Chris P. Gale, Tom J. R. De Potter, Isabelle C. van Gelder, null null, Yann Allali, Asgher Champsi, Thomas Deneke, Kaitlyn Greeley, Benoît Guy-Moyat, Mikael Laredo, Alastair Mobley, Maximina Ventura, Mary
Published in: Nature Medicine, Issue 31, 2025, Page(s) 2647-2654, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-025-03751-2

Protease-activated receptor 2 at the intersection of thrombo-inflammation and beyond

Author(s): Anke C. Fender, Dobromir Dobrev
Published in: IJC Heart & Vasculature, Issue 52, 2024, Page(s) 101403, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101403

Preventative Imaging with Coronary Computed Tomography Angiography

Author(s): Alexios S. Antonopoulos, Spyridon Simantiris
Published in: Current Cardiology Reports, Issue 25, 2023, Page(s) 1623-1632, ISSN 1523-3782
Publisher: Current Science Inc.
DOI: 10.1007/s11886-023-01982-8

Non-neuronal ventricular cardiomyocyte-located nicotinergic acetylcholine receptors cause remodelling and arrhythmias

Author(s): Sami F Noujaim, Dobromir Dobrev
Published in: European Heart Journal, Issue 46, 2025, Page(s) 1247-1249, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae845

The thrombin receptor PAR4 supports visceral adipose tissue inflammation

Author(s): Sonja Kleeschulte, Vivien Fischinger, Lisa Öhlke, Johannes Bode, Markus Kamler, Dobromir Dobrev, Maria Grandoch, Anke C. Fender
Published in: Naunyn-Schmiedeberg's Archives of Pharmacology, Issue 397, 2024, Page(s) 7187-7200, ISSN 0028-1298
Publisher: Springer Verlag
DOI: 10.1007/s00210-024-03097-5

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis,

Author(s): Zeemering S, Isaacs A, Winters J, et al.
Published in: Zeemering S, Isaacs A, Winters J, et al., 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2022.08.019

Detectable troponin below the 99th percentile predicts survival in patients undergoing coronary angiography

Author(s): Lars Michel, Stefanie Jehn, Iryna Dykun, Markus S. Anker, Peter Ferdinandy, Dobromir Dobrev, Tienush Rassaf, Amir A. Mahabadi, Matthias Totzeck
Published in: IJC Heart & Vasculature, Issue 52, 2024, Page(s) 101419, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101419

Heart failure pharmacotherapy and cancer: pathways and pre-clinical/clinical evidence

Author(s): Nabil V Sayour, Ágnes M Paál, Pietro Ameri, Wouter C Meijers, Giorgio Minotti, Ioanna Andreadou, Antonella Lombardo, Massimiliano Camilli, Heinz Drexel, Erik Lerkevang Grove, Gheorghe Andrei Dan, Andreea Ivanescu, Anne Grete Semb, Gianluigi Savarese, Dobromir Dobrev, Filippo Crea, Juan-Carlos Kaski, Rudolf A de Boer, Péter Ferdinandy, Zoltán V Varga
Published in: European Heart Journal, Issue 45, 2024, Page(s) 1224-1240, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae105

Great Debate: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting should be limited to 1 week

Author(s): Galli M, Agewall S, Andreotti F, et al.
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac294

Phenotyping patients with chronic obstructive pulmonary disease and heart failure

Author(s): Peter Moritz Becher, Felix Lindberg, Lina Benson, Camilla Hage, Ulf Dahlström, Stephan Rosenkranz, Francesco Cosentino, Giuseppe M.C. Rosano, Stefan Blankenberg, Paulus Kirchhof, Frieder Braunschweig, Lars H. Lund, Gianluigi Savarese
Published in: ESC Heart Failure, Issue 12, 2025, Page(s) 900-911, ISSN 2055-5822
Publisher: Wiley
DOI: 10.1002/ehf2.15127

Association between retinopathy and development of long-term cardiovascular events. Results of the follow-up of RETICARD cohort

Author(s): Aguila Gordo D, Marina-Breysse M, Piqueras Flores J, et al.
Published in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab061.218

Safety and efficacy of long-term sodium channel blocker therapy for early rhythm control: the EAST-AFNET 4 trial

Author(s): Andreas Rillig, Lars Eckardt, Katrin Borof, A John Camm, Harry J G M Crijns, Andreas Goette, Günter Breithardt, Marc D Lemoine, Andreas Metzner, Laura Rottner, Ulrich Schotten, Eik Vettorazzi, Karl Wegscheider, Antonia Zapf, Hein Heidbuchel, Stephan Willems, Larissa Fabritz, Renate B Schnabel, Christina Magnussen, Paulus Kirchhof
Published in: Europace, Issue 26, 2024, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euae121

Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery

Author(s): Martijn D. Gilbers, Michal J. Kawczynski, Elham Bidar, Bart Maesen, Aaron Isaacs, Joris Winters, Dominik Linz, Michiel Rienstra, Isabelle van Gelder, Jos G. Maessen, Ulrich Schotten
Published in: JACC: Clinical Electrophysiology, Issue 10, 2024, Page(s) 941-955, ISSN 2405-500X
Publisher: Elsevier BV
DOI: 10.1016/j.jacep.2024.01.013

Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences

Author(s): Goette A, Lendeckel U
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10102605

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

Author(s): Maesen B, Verhuele S, Zeemering S, et al.
Published in: EP Europace, 2022, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac026

Recent highlights from the International Journal of Cardiology Heart and Vasculature: Spatiotemporal and functional immunoprofiling and its theranostic potential

Author(s): Florian Bruns, Dobromir Dobrev, Anke C. Fender
Published in: IJC Heart & Vasculature, Issue 53, 2024, Page(s) 101468, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101468

Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation

Author(s): Larissa Fabritz, Stephane N. Hatem, Samuel Sossalla
Published in: Nature Reviews Cardiology, 2025, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-025-01195-2

Anticoagulation with edoxaban in patients with long atrial high-rate episodes ≥24 h

Author(s): Nina Becher, Tobias Toennis, Emanuele Bertaglia, Carina Blomström-Lundqvist, Axel Brandes, Nuno Cabanelas, Melanie Calvert, A John Camm, Gregory Chlouverakis, Gheorghe-Andrei Dan, Wolfgang Dichtl, Hans Christoph Diener, Alexander Fierenz, Andreas Goette, Joris R de Groot, Astrid N L Hermans, Gregory Y H Lip, Andrzej Lubinski, Eloi Marijon, Béla Merkely, Lluís Mont, Ann-Kathrin Ozga, Kim Rajappa
Published in: European Heart Journal, Issue 45, 2024, Page(s) 837-849, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehad771

Safety and efficacy of amiodarone and dronedarone for early rhythm control in EAST-AFNET 4

Author(s): Laura Rottner, Marc D. Lemoine, Lars Eckardt, Katrin Borof, A. John Camm, Andreas Goette, Günter Breithardt, Andreas Metzner, Ulrich Schotten, Antonia Zapf, Hein Heidbüchel, Stephan Willems, Harry Crijns, Renate B. Schnabel, Larissa Fabritz, Christina Magnussen, Andreas Rillig, Paulus Kirchhof
Published in: Clinical Research in Cardiology, 2025, ISSN 1861-0684
Publisher: Steinkopff
DOI: 10.1007/s00392-025-02637-0

Macrophage-mediated IL-6 signaling drives ryanodine receptor–2 calcium leak in postoperative atrial fibrillation

Author(s): Joshua A. Keefe, Yuriana Aguilar-Sanchez, J. Alberto Navarro-Garcia, Isabelle Ong, Luge Li, Amelie Paasche, Issam Abu-Taha, Marcel A. Tekook, Florian Bruns, Shuai Zhao, Markus Kamler, Ying H. Shen, Mihail G. Chelu, Na Li, Dobromir Dobrev, Xander H.T. Wehrens
Published in: Journal of Clinical Investigation, Issue 135, 2025, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci187711

Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction

Author(s): Larissa Fabritz, Lisa Fortmueller, Katja Gehmlich, Sebastian Kant, Marcel Kemper, Dana Kucerova, Fahima Syeda, Cornelius Faber, Rudolf E. Leube, Paulus Kirchhof, Claudia A. Krusche
Published in: Biomedicines, Issue 12, 2025, Page(s) 985, ISSN 2227-9059
Publisher: MDPI AG
DOI: 10.3390/biomedicines12050985

Diabetes and Obesity and Treatment Effect of Early Rhythm Control vs Usual Care in Patients With Atrial Fibrillation

Author(s): Andreas Metzner, Stephan Willems, Katrin Borof, Guenther Breithardt, A. John Camm, Harry J. G. M. Crijns, Lars Eckardt, Larissa Fabritz, Nele Gessler, Andreas Goette, Bruno Reissmann, Renate B. Schnabel, Ulrich Schotten, Antonia Zapf, Andreas Rillig, Paulus Kirchhof
Published in: JAMA Cardiology, Issue 10, 2025, Page(s) 932, ISSN 2380-6583
Publisher: American Medical Association (AMA)
DOI: 10.1001/jamacardio.2025.2374

Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology

Author(s): Jose L Merino, Juan Tamargo, Carina Blomström-Lundqvist, Giuseppe Boriani, Harry J G M Crijns, Dobromir Dobrev, Andreas Goette, Stefan H Hohnloser, Gerald V Naccarelli, James A Reiffel, Jacob Tfelt-Hansen, Marcel Martínez-Cossiani, A John Camm, Jesus M Almendral Garrote, Beata Średniawa, Piotr Kułakowski, Irina Savelieva, Tatjana Potpara, Bulent Gorenek, Jose L Zamorano
Published in: Europace, Issue 27, 2025, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaf076

Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti.

Author(s): Heijman J, Dobrev D.
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac357

From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics

Author(s): Arnela Saljic, Jordi Heijman, Dobromir Dobrev
Published in: European Cardiology Review, Issue 19, 2024, ISSN 1758-3756
Publisher: Radcliffe Publishing Ltd.
DOI: 10.15420/ecr.2024.41

Outcomes and Management of Stressor-Associated Atrial Fibrillation

Author(s): Julian S. Haimovich, Shinwan Kany, Ezimamaka Ajufo, Jason G. Andrade, Emelia J. Benjamin, Jeffrey S. Healey, Paulus Kirchhof, Steven A. Lubitz, William F. McIntyre, Michiel Rienstra, Prashanthan Sanders, Renate B. Schnabel, Patrick T. Ellinor, Shaan Khurshid
Published in: JACC, Issue 86, 2025, Page(s) 910-939, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2025.07.031

Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value

Author(s): Daniel Enríquez-Vázquez, Jorge G. Quintanilla, Alba García-Escolano, Marinela Couselo-Seijas, Ana Simón-Chica, Peter Lee, José Manuel Alfonso-Almazán, Patricia Mahía, Andrés Redondo-Rodríguez, Javier Modrego, Adriana Ortega-Hernández, Pedro Marcos-Alberca, Ricardo Magni, Enrique Calvo, Rubén Gómez-Gordo, Ping Yan, Giulio La Rosa, José Bustamante-Madrión, Carlos Nicolás Pérez-Garcí
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40196-y

Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes

Author(s): Claudia Mittendorff, Issam Abu-Taha, Lena Kassler, Tobias Hustedt, Stephanie Wolf, Johannes G. Bode, Markus Kamler, Dobromir Dobrev, Anke C. Fender
Published in: Naunyn-Schmiedeberg's Archives of Pharmacology, Issue 398, 2025, Page(s) 2783-2796, ISSN 0028-1298
Publisher: Springer Verlag
DOI: 10.1007/s00210-024-03436-6

Fat chance for POAF? Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation

Author(s): Gawałko M, Dobrev D
Published in: Int J Cardiol Heart Vasc, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101000

Inflammatory gut-heart interactions: Is there a link between inflammatory bowel disease and atrial fibrillation?

Author(s): Dobromir Dobrev, Anke C. Fender
Published in: IJC Heart & Vasculature, Issue 55, 2025, Page(s) 101537, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101537

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development

Author(s): Pablo Gómez-del Arco, Joan Isern, Daniel Jimenez-Carretero, Dolores López-Maderuelo, Rebeca Piñeiro-Sabarís, Fadoua El Abdellaoui-Soussi, Carlos Torroja, María Linarejos Vera-Pedrosa, Mercedes Grima-Terrén, Alberto Benguria, Ana Simón-Chica, Antonio Queiro-Palou, Ana Dopazo, Fátima Sánchez-Cabo, José Jalife, José Luis de la Pompa, David Filgueiras-Rama, Pura Muñoz-Cánoves, Juan Miguel
Published in: Nature Communications, Issue 15, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52809-1

Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation and Heart Failure With Diastolic Dysfunction

Author(s): Luge Li, Cristian Coarfa, Yue Yuan, Issam Abu-Taha, Xiaolei Wang, Jia Song, Yuying Zeng, Xiaohui Chen, Amrit Koirala, Sandra L. Grimm, Markus Kamler, Lisa K. McClendon, Michelle Tallquist, Stanley Nattel, Dobromir Dobrev, Na Li
Published in: JACC: Basic to Translational Science, Issue 10, 2025, Page(s) 101244, ISSN 2452-302X
Publisher: Elsevier BV
DOI: 10.1016/j.jacbts.2025.02.004

Recent highlights from the International Journal of Cardiology Heart & Vasculature: Basic and translational research

Author(s): Anke C. Fender, Dobromir Dobrev
Published in: IJC Heart & Vasculature, Issue 53, 2024, Page(s) 101452, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101452

The virtual patient – Estimating the health utility of aspirin in simulated populations

Author(s): Fender AC, Dobrev D
Published in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100857

Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS)

Author(s): Andreas Goette, Domenico Corradi, Dobromir Dobrev, Luis Aguinaga, Jose-Angel Cabrera, Sumeet S Chugh, Joris R de Groot, Laurie Soulat-Dufour, Guilherme Fenelon, Stephane N Hatem, Jose Jalife, Yenn-Jiang Lin, Gregory Y H Lip, Gregory M Marcus, Katherine T Murray, Hui-Nam Pak, Ulrich Schotten, Naohiko Takahashi, Takanori Yamaguchi, William A Zoghbi, Stanley Nattel, Lluis Mont, Joseph G Akar, Nazem A
Published in: Europace, Issue 26, 2025, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euae204

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Author(s): Joris Winters, Michal J. Kawczynski, Martijn D. Gilbers, Aaron Isaacs, Stef Zeemering, Elham Bidar, Bart Maesen, Michiel Rienstra, Isabelle van Gelder, Sander Verheule, Jos G. Maessen, Ulrich Schotten
Published in: JACC: Clinical Electrophysiology, Issue 10, 2025, Page(s) 1326-1340, ISSN 2405-500X
Publisher: Elsevier BV
DOI: 10.1016/j.jacep.2024.03.003

Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology

Author(s): Chaumont C, Suffee N, Gandjbakhch E, et al.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab213

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

Author(s): Gawalko M, Saljic A, Li N, et al.
Published in: Cardiovascular Research, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac093

Using pericoronary fat attenuation to guide management after coronary interventions

Author(s): Charalambos Antoniades, Kenneth Chan
Published in: EuroIntervention, Issue 21, 2025, Page(s) e589-e591, ISSN 1969-6213
Publisher: Europa Digital & Publishing
DOI: 10.4244/eij-e-25-00018

Lower left ventricular ejection time in <i>MYBPC3</i> variant carriers with overt or subclinical hypertrophic cardiomyopathy

Author(s): Isabell Yan, Zoe Möhring, Daniel Reichart, Fanny Kortüm, Julia Münch, Rixa Woitschach, Paulus Kirchhof, Lucie Carrier, Carolyn Y. Ho, Thomas Eschenhagen, Monica Patten
Published in: ESC Heart Failure, Issue 12, 2025, Page(s) 3416-3425, ISSN 2055-5822
Publisher: Wiley
DOI: 10.1002/ehf2.15346

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Author(s): Nattel S, Sager PT, Hüser J, Heijman J, Dobrev D.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab093

Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice

Author(s): Suffee N, Baptista E, Piquereau J, et al.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab367

An economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from a German healthcare payer perspective

Author(s): Malte Kuniss, Lucy Hillcoat, Joe Moss, Florian Straube, Jason Andrade, Oussama Wazni, Gian Battista Chierchia, Lukas Schwegmann, Eleni Ismyrloglou, Alicia Sale, Stuart Mealing, Tom Bromilow, Emily Lane, Damian Lewis, Andreas Goette
Published in: BMC Health Services Research, Issue 24, 2024, ISSN 1472-6963
Publisher: BioMed Central
DOI: 10.1186/s12913-024-11967-0

Practical approach for atrial cardiomyopathy characterization in patients with atrial fibrillation

Author(s): Giulio La Rosa, Carlos A. Morillo, Jorge G. Quintanilla, Adelina Doltra, Lluis Mont, Moisés Rodríguez-Mañero, Andrea Sarkozy, José Luis Merino, David Vivas, Tomás Datino, David Calvo, Nicasio Pérez-Castellano, Julián Pérez-Villacastín, Laurent Fauchier, Gregory Lip, Stéphane N. Hatem, José Jalife, Laura Sanchis, Francisco Marín, David Filgueiras-Rama
Published in: Revista Española de Cardiología (English Edition), Issue 77, 2024, Page(s) 656-666, ISSN 1885-5857
Publisher: Elsevier BV
DOI: 10.1016/j.rec.2024.02.009

Atrial fibrillation does not equal atrial fibrillation: The important prognostic implications of new-onset atrial fibrillation

Author(s): Andreas Goette, Raffaele De Caterina, Joris R. de Groot, Dobromir Dobrev
Published in: IJC Heart & Vasculature, Issue 56, 2025, Page(s) 101572, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101572

Ceramides in cardiovascular disease: emerging role as independent risk predictors and novel therapeutic targets

Author(s): Roland Klingenberg, Andreas Leiherer, Dobromir Dobrev, Juan C Kaski, Bodo Levkau, Winfried März, Samuel Sossalla, Arnold von Eckardstein, Heinz Drexel
Published in: Cardiovascular Research, 2025, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaf093

Recent highlights from the International Journal of Cardiology heart & Vasculature: Comprehensive management of atrial fibrillation

Author(s): Dominik Linz, Dobromir Dobrev
Published in: IJC Heart & Vasculature, Issue 53, 2024, Page(s) 101478, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101478

General anaesthesia and deep sedation for monopolar pulsed field ablation using a lattice-tip catheter combined with a novel three-dimensional mapping system

Author(s): Andreas Rillig, Jun Hirokami, Fabian Moser, Stefano Bordignon, Laura Rottner, Tohoku Shota, Ilaria My, Andrea Urbani, Marc Lemoine, Joseph Kheir, Niklas Schenker, Lukas Urbanek, Katarina Govorov, David Schaack, Julius Obergassel, Jan Riess, Djemail Ismaili, Paulus Kirchhof, Feifan Ouyang, Boris Schmidt, Bruno Reissmann, Kyoung-Ryul Julian Chun, Andreas Metzner
Published in: Europace, Issue 26, 2024, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euae270

Dronedarone provides effective early rhythm control: post-hoc analysis of the ATHENA trial using EAST-AFNET 4 criteria

Author(s): Paulus Kirchhof, A John Camm, Harry J G M Crijns, Jonathan P Piccini, Christian Torp-Pedersen, David S McKindley, Mattias Wieloch, Stefan H Hohnloser
Published in: Europace, Issue 27, 2025, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaf080

Does gut microbiota affect atrial rhythm? Causalities & Speculations

Author(s): Linz D, Gawałko M, Sanders P, Penders J, Li N, Nattel S, Dobrev D
Published in: Eur Heart J, 2021, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab467

Scalable screening for structural heart disease: promises from artificial intelligence-electrocardiogram tools

Author(s): Charalambos Antoniades, Kenneth Chan
Published in: European Heart Journal - Digital Health, Issue 6, 2025, Page(s) 521-523, ISSN 2634-3916
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjdh/ztaf048

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

Author(s): Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman
Published in: The Journal of Physiology, 2025, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp288659

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

Author(s): Salic A, Heijman J, Dobrev D
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084096

Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts

Author(s): Constantin Mann, Carolin van Alst, Simone Gorressen, Rachel Nega, Dobromir Dobrev, Maria Grandoch, Anke C. Fender
Published in: Naunyn-Schmiedeberg's Archives of Pharmacology, Issue 397, 2024, Page(s) 7201-7212, ISSN 0028-1298
Publisher: Springer Verlag
DOI: 10.1007/s00210-024-03107-6

Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation

Author(s): Sean J. Jurgens, Giorgio E.M. Melloni, Shinwan Kany, Larissa Fabritz, Joel T. Rämö, Andreas Goette, Frederick K. Kamanu, David D. Berg, Christina Magnussen, Seung Hoan Choi, Marc P. Bonaca, Robert P. Giugliano, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Philippe Gabriel Steg, Itamar Raz, Eugene Braunwald, James P. Pirruccello, Marc S. Sabatine, Nicholas A. Marston, Paulus Kirchhof
Published in: JACC, Issue 86, 2025, Page(s) 738-753, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2025.06.052

Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome.

Author(s): Manuel AIM, Jalife J, et al.
Published in: Cardiovascular Research, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac118

Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis

Author(s): Yue Yuan, Pascal Martsch, Xiaohui Chen, Enrique Martinez, Luge Li, Jia Song, Theresa Poppenborg, Florian Bruns, Jong Hwan Kim, Markus Kamler, James F Martin, Issam Abu-Taha, Dobromir Dobrev, Na Li
Published in: European Heart Journal, Issue 46, 2025, Page(s) 1250-1262, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaf024

Pro‐adrenomedullin associates with congestion in acute heart failure patients

Author(s): Benedikt N. Beer, Saman Keshtkaran, Caroline Kellner, Lisa Besch, Jonas Sundermeyer, Angela Dettling, Paulus Kirchhof, Stefan Blankenberg, Christina Magnussen, Benedikt Schrage
Published in: ESC Heart Failure, Issue 11, 2024, Page(s) 3598-3606, ISSN 2055-5822
Publisher: Wiley
DOI: 10.1002/ehf2.15007

Calcification vs Inflammation

Author(s): Charalambos Antoniades, Kenneth Chan
Published in: JACC: Cardiovascular Imaging, Issue 17, 2025, Page(s) 1225-1228, ISSN 1936-878X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmg.2024.08.006

Common disease-promoting signaling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences

Author(s): Keefe JA, Wehrens XT, Dobrev D
Published in: Cardiovascular Research, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac107

Using artificial intelligence to study atherosclerosis from computed tomography imaging: A state-of-the-art review of the current literature

Author(s): Laura Valentina Klüner, Kenneth Chan, Charalambos Antoniades
Published in: Atherosclerosis, Issue 398, 2024, Page(s) 117580, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.117580

Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge

Author(s): Linz D, Linz B, Dobrev D, Baumert M, Hendriks JM, Pepin JL, Jespersen T
Published in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100843

Lp(a) and vascular inflammation: data from perivascular fat attenuation index measurements

Author(s): S Simantiris, A S Antonopoulos, I Skoumas, I Andrikou, K Grigoriou, I Dima, C Antoniades, D Cokkinos, D Tousoulis, K Tsioufis, C Vlachopoulos
Published in: European Journal of Preventive Cardiology, Issue 31, 2024, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwae175.297

Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography

Author(s): Apostolos Tsiachristas, Kenneth Chan, Elizabeth Wahome, Ben Kearns, Parijat Patel, Maria Lyasheva, Nigar Syed, Sam Fry, Thomas Halborg, Henry West, Edward Nicol, David Adlam, Bhavik Modi, Attila Kardos, John P Greenwood, Nikant Sabharwal, Giovanni Luigi De Maria, Shahzad Munir, Elisa McAlindon, Yogesh Sohan, Pete Tomlins, Muhammad Siddique, Cheerag Shirodaria, Ron Blankstein, Milind Desai, Stefan
Published in: European Heart Journal - Quality of Care and Clinical Outcomes, Issue 11, 2025, Page(s) 434-444, ISSN 2058-5225
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjqcco/qcae085

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Author(s): Dominik Linz, Jason G Andrade, Elena Arbelo, Giuseppe Boriani, Guenter Breithardt, A John Camm, Valeria Caso, Jens Cosedis Nielsen, Mirko De Melis, Tom De Potter, Wolfgang Dichtl, Søren Zoega Diederichsen, Dobromir Dobrev, Nicolas Doll, David Duncker, Elke Dworatzek, Lars Eckardt, Christoph Eisert, Larissa Fabritz, Michal Farkowski, David Filgueiras-Rama, Andreas Goette, Eduard Guasch, Guido Hack
Published in: Europace, Issue 26, 2024, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euae070

Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors: a win ratio analysis of the NOAH-AFNET 6 trial

Author(s): Nina Becher, Gina Köllner, Emanuele Bertaglia, Carina Blomstrom-Lundqvist, Axel Brandes, Vincent Beuger, Melanie Calvert, A John Camm, Nuno Cabanelas, Gregory Chlouverakis, Gheorghe-Andrei Dan, Wolfgang Dichtl, Hans Christoph Diener, Alexander Fierenz, Andreas Goette, Joris R de Groot, Lieven Nils Kennes, Gregory Y H Lip, Andrzej Lubinski, Eloi Marijon, Béla Merkely, Lluís Mont, Kim Rajappan, U
Published in: European Heart Journal - Quality of Care and Clinical Outcomes, 2025, ISSN 2058-5225
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjqcco/qcaf087

Evaluating artificial intelligence-enabled medical tests in cardiology: Best practice

Author(s): Jonas L. Isaksen, Malene Nørregaard, Martin Manninger, Dobromir Dobrev, Thomas Jespersen, Ben Hermans, Jordi Heijman, Gernot Plank, Daniel Scherr, Thomas Pock, Vajira Thambawita, Michael A. Riegler, Jørgen K. Kanters, Dominik Linz
Published in: IJC Heart & Vasculature, Issue 60, 2025, Page(s) 101783, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2025.101783

Minding the gap – Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines

Author(s): Fender AC, Bruns F, Dobrev D
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2021.12.030

Recent highlights from the International Journal of Cardiology Heart & Vasculature: cardiometabolic disease

Author(s): Florian Bruns, Hannah Märte, Dobromir Dobrev, Anke Fender
Published in: IJC Heart & Vasculature, Issue 60, 2025, Page(s) 101779, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2025.101779

Challenges and Opportunities in Improving the Management of Atrial Fibrillation: Recent Research Advances and their Clinical Translation

Author(s): Nattel S, Lip GYH, Filgueiras-Rama D, Dobrev D
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab170

Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation

Author(s): Arne van Hunnik, Vladimír Sobota, Stef Zeemering, Dragan Opacic, Billy Scaf, Elisa D’Alessandro, Karel Oyaert, Marion Kuiper, Jonas G. Diness, Ulrik S. Sørensen, James T. Milnes, Marcel A. G. van der Heyden, Thomas Jespersen, Ulrich Schotten, Sander Verheule
Published in: Frontiers in Physiology, Issue 15, 2024, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2024.1399037

Towards improved detection of subclinical atrial fibrillation – Who could benefit from targeted screening?

Author(s): Anke C. Fender, Dobromir Dobrev
Published in: IJC Heart & Vasculature, Issue 55, 2025, Page(s) 101550, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101550

Spexin Hormone Signaling and Atrial Fibrillation: The Knowns and Unknowns

Author(s): Jordi Heijman, Dobromir Dobrev
Published in: Circulation, Issue 150, 2025, Page(s) 128-131, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.124.070016

Genetic testing in early-onset atrial fibrillation

Author(s): Shinwan Kany, Sean J Jurgens, Joel T Rämö, Ingrid E Christophersen, Michiel Rienstra, Mina K Chung, Morten S Olesen, Michael J Ackerman, Elizabeth M McNally, Christopher Semsarian, Renate B Schnabel, Arthur A M Wilde, Emelia J Benjamin, Heidi L Rehm, Paulus Kirchhof, Connie R Bezzina, Dan M Roden, M Benjamin Shoemaker, Patrick T Ellinor
Published in: European Heart Journal, Issue 45, 2024, Page(s) 3111-3123, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae298

Evolution in electrophysiology 100 years after Einthoven: translational and computational innovations in rhythm control of atrial fibrillation

Author(s): Eva Schuijt, Daniel Scherr, Gernot Plank, Ulrich Schotten, Jordi Heijman
Published in: Europace, Issue 27, 2025, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euae304

Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Author(s): Blandin CE, Gravez BJ, Hatem SN, Balse E.
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10092417

Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation – unmet clinical needs

Author(s): Bruns F, Dobrev D, Fender AC
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.08.019

Proteomics: a promising approach to discover new biomarkers for atrial fibrillation

Author(s): Song J, Dobrev D, Li N
Published in: Int J Cardiol, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2021.10.135

Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study

Author(s): Larissa Fabritz, Winnie Chua, Victor R Cardoso, Christoph Al-Taie, Katrin Borof, Anna Suling, Linda Krause, Shinwan Kany, Christina Magnussen, Karl Wegscheider, Guenter Breithardt, Harry J G M Crijns, A John Camm, George Gkoutos, Patrick T Ellinor, Andreas Goette, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Renate B Schnabel, Antonia Zapf, Paulus Kirchhof
Published in: Cardiovascular Research, Issue 120, 2024, Page(s) 855-868, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvae067

Pathophysiological differences between atrial fibrillation subgoups: Is there a fibrillatory-induced atherosclerotic disease progression?

Author(s): Goette A.
Published in: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100892

Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?

Author(s): Dobrev D, Dudley SC.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab124

Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats

Author(s): Bukowska A, Nikonova Y, Wolke C, et al.
Published in: IJC Heart & Vasculature, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101088

Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches

Author(s): Ulrich Schotten, Andreas Goette, Sander Verheule
Published in: Nature Reviews Cardiology, Issue 22, 2025, Page(s) 225-240, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-024-01088-w

Short-term benefit of early rhythm control for atrial fibrillation: the EAST-AFNET 4 trial

Author(s): Julius Obergassel, Anna Suling, Katrin Borof, Alan John Camm, Harry J G M Crijns, Lars Eckardt, Larissa Fabritz, Andreas Goette, Märit Jensen, Marc Daniel Lemoine, Christina Magnussen, Andreas Metzner, Andreas Rillig, Ulrich Schotten, Renate Schnabel, Götz Thomalla, Panos Vardas, Reza Wakili, Stephan Willems, Antonia Zapf, Paulus Kirchhof, Benedikt Schrage
Published in: European Heart Journal, Issue 46, 2025, Page(s) 3663-3666, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaf397

Pilot study to evaluate the use of remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): study protocol for a randomised controlled trial delivered in two tertiary cardiac centres in the UK

Author(s): Nazish Khan, Richard P Steeds, Derek Kyte, Larissa Fabritz, Philip Collis, Winnie Chua, Clive Stubbs, Samir Mehta, Yongzhong Sun, Mary Nulty, Katie Kirkham, James M Cotton
Published in: BMJ Open, Issue 14, 2024, Page(s) e086587, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-086587

Inflammatory signaling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

Author(s): Dobrev D, Heijman J, Hiram R, Li N, Nattel S
Published in: Nat Rev Cardiol, 2022, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-022-00759-w

The inflammatory and nutritional status in patients with dilated cardiomyopathy: Different impact for distinct phenogroups?

Author(s): Tobias Lerchner, Anke Fender, Dobromir Dobrev, Tienush Rassaf, Lars Michel
Published in: IJC Heart & Vasculature, Issue 56, 2025, Page(s) 101610, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2025.101610

High-Density and High-Coverage Composite Atrial Activation Maps: An In-Silico Validation Study

Author(s): Ozan Özgül, Victor G. Marques, Ben JM Hermans, Arne van Hunnik, Sander Verheule, Ali Gharaviri, Simone Pezzuto, Angelo Auricchio, Ulrich Schotten, Pietro Bonizzi, Stef Zeemering
Published in: IEEE Transactions on Biomedical Engineering, Issue 72, 2025, Page(s) 79-89, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2024.3439502

Stretching the limits of antiarrhythmic drug therapy: the promise of small-conductance calcium-activated potassium channel blockers

Author(s): Heijman J, Rahm AK, Dobrev D
Published in: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100924

Oral anticoagulation in device-detected atrial fibrillation: effects of age, sex, cardiovascular comorbidities, and kidney function on outcomes in the NOAH-AFNET 6 trial

Author(s): Gregory Y H Lip, Julius Nikorowitsch, Susanne Sehner, Nina Becher, Emanuele Bertaglia, Carina Blomstrom-Lundqvist, Axel Brandes, Vincent Beuger, Melanie Calvert, A John Camm, Gregory Chlouverakis, Gheorghe-Andrei Dan, Wolfgang Dichtl, Hans Christoph Diener, Alexander Fierenz, Andreas Goette, Joris R de Groot, Astrid Hermans, Andrzej Lubinski, Eloi Marijon, Béla Merkely, Lluís Mont, Ann-Kathrin O
Published in: European Heart Journal, Issue 45, 2024, Page(s) 1733-1737, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae225

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

Author(s): Schnabel RB, Marinelli EA, Arbelo E, et al.
Published in: EP Europace, 2022, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac062

Critical medications in cardiology: strategic policy of the European Medicines Agency

Author(s): Dobromir Dobrev, Juan Tamargo, Piotr Szymański
Published in: European Heart Journal, Issue 46, 2025, Page(s) 2491-2493, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaf134

Childhood infection and modern malnutrition: do childhood infections create an inflammatory foundation for atherosclerosis in adult life?

Author(s): Fender A, Dobrev D
Published in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100840

Determinants and impact of postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery: Results from the RACE V prospective cohort study

Author(s): Martijn D. Gilbers, Michal J. Kawczynski, Elham Bidar, Bart Maesen, Aaron Isaacs, Joris Winters, Dominik Linz, Michiel Rienstra, Isabelle van Gelder, Jos G. Maessen, Ulrich Schotten
Published in: Heart Rhythm, Issue 22, 2025, Page(s) 647-660, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.08.014

Deep-Learning for Epicardial Adipose Tissue Assessment With Computed Tomography

Author(s): Henry W. West, Muhammad Siddique, Michelle C. Williams, Lucrezia Volpe, Ria Desai, Maria Lyasheva, Sheena Thomas, Katerina Dangas, Christos P. Kotanidis, Pete Tomlins, Ciara Mahon, Attila Kardos, David Adlam, John Graby, Jonathan C.L. Rodrigues, Cheerag Shirodaria, John Deanfield, Nehal N. Mehta, Stefan Neubauer, Keith M. Channon, Milind Y. Desai, Edward D. Nicol, David E. Newby, Charalambos Anton
Published in: JACC: Cardiovascular Imaging, Issue 16, 2023, Page(s) 800-816, ISSN 1936-878X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmg.2022.11.018

TGF-β1-induced endothelial-to-mesenchymal transition: a potential contributor to atrial fibrillation promoting fibrotic remodeling?

Author(s): Saljic A, Grandi E, Dobrev D
Published in: J Clin Invest, 2022, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci161070

Using artificial intelligence to spot heart failure from ECGs: is it prime time?

Author(s): Charalambos Antoniades, Kenneth Chan
Published in: European Heart Journal, Issue 46, 2025, Page(s) 1054-1056, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae906

Pregnancy & cardiovascular disease: the PREG-CVD-HH registry

Author(s): Dora Csengeri, Elisabeth Unger, Jessica Weimann, Michael Huntgeburth, Yskert von Kodolitsch, Tanja Zeller, Stefan Blankenberg, Paulus Kirchhof, Anke Diemert, Renate B. Schnabel, Christoph R. Sinning, Elvin Zengin-Sahm
Published in: Cardiovascular Diagnosis and Therapy, Issue 14, 2024, Page(s) 1058-1069, ISSN 2223-3652
Publisher: AME Publishing Company
DOI: 10.21037/cdt-24-248

Ventricular arrhythmias in acute heart failure. A clinical consensus statement of the Association for Acute <scp>CardioVascular</scp> Care (<scp>ACVC</scp>), the European Heart Rhythm Association (<scp>EHRA</scp>) and the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp>

Author(s): Bulent Gorenek, Adrianus P. Wijnmaalen, Andreas Goette, Gurbet Ozge Mert, Bradley Porter, Finn Gustafsson, Gheorghe Andrei Dan, Joris Ector, Markus Stuehlinger, Michael Spartalis, Nils Gosau, Offer Amir, Ovidiu Chioncel
Published in: European Journal of Heart Failure, Issue 27, 2025, Page(s) 1606-1621, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.3645

Improving antiarrhythmic therapy for patients with atrial fibrillation using common genetic variants

Author(s): Marc D Lemoine, Larissa Fabritz
Published in: Heart, Issue 111, 2025, Page(s) 145-146, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2024-325242

PITX2 deficiency leads to atrial mitochondrial dysfunction

Author(s): Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéphane N Hatem, Joris Winters, Stef Zeemering, Neil V Morgan, Julie Rayes, Katja Gehmlich, Mo
Published in: Cardiovascular Research, Issue 120, 2024, Page(s) 1907-1923, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvae169

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Author(s): Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew C. Hill, Christopher M. Haggerty, Garðar Sveinbjörnsson, Valerie N. Morrill, Nicholas A. Marston, Lu-Chen Weng, James P. Pirruccello, David O. Arnar, Daniel Fannar Gudbjartsson, Helene Mantineo, Aenne S. von Falkenhausen, Andrea Natale, Arnljot Tveit, Bastiaan Geelhoed, Carolina Roselli, David R. Van Wagoner, Dawood Darbar, Doreen Haase, Elsay
Published in: Nature Genetics, Issue 57, 2025, Page(s) 548-562, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02074-9

Cardiac magnetic resonance imaging in patients with suspected myocarditis from immune checkpoint inhibitor therapy – A real-world observational study

Author(s): Tobias Lerchner, Raluca I. Mincu, Florian Bühning, Julia Vogel, Karin Klingel, Mathias Meetschen, Thomas Schlosser, Johannes Haubold, Lale Umutlu, Dobromir Dobrev, Matthias Totzeck, Tienush Rassaf, Lars Michel
Published in: IJC Heart & Vasculature, Issue 56, 2025, Page(s) 101581, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101581

Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms

Author(s): Lucilla Giammarino, Lluis Matas, Nicolò Alerni, András Horváth, Varjany Vashanthakumar, Saranda Nimani, Miriam Barbieri, Sahej Bains, Ruben Lopez, Julien Louradour, Balazs Ördög, Thomas Hof, Ange Maguy, Giulio Conte, Angelo Auricchio, Ulrich Schotten, Katja E Odening
Published in: Cardiovascular Research, Issue 121, 2025, Page(s) 1215-1227, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaf074

Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation?

Author(s): Cai M, Schotten U, Dobrev D, Heijman J.
Published in: International Journal of Cardiology, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.07.027

New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2024

Author(s): Juan Tamargo, Stefan Agewall, Giuseppe Ambrosio, Claudio Borghi, Elisabetta Cerbai, Gheorghe A Dan, Heinz Drexel, Péter Ferdinandy, Erik Lerkevang Grove, Roland Klingenberg, Joao Morais, William Parker, Bianca Rocca, Patrick Sulzgruber, Anne Grete Semb, Samuel Sossalla, Juan Carlos Kaski, Dobromir Dobrev
Published in: European Heart Journal - Cardiovascular Pharmacotherapy, Issue 11, 2025, Page(s) 292-317, ISSN 2055-6837
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjcvp/pvaf012

Assessment of atrial function by echocardiography: can this be used to assess the arrhythmogenic atrial substrate?

Author(s): Bruns F, Dobrev D
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.05.070

Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study

Author(s): Kenneth Chan, Elizabeth Wahome, Apostolos Tsiachristas, Alexios S Antonopoulos, Parijat Patel, Maria Lyasheva, Lucy Kingham, Henry West, Evangelos K Oikonomou, Lucrezia Volpe, Michail C Mavrogiannis, Edward Nicol, Tarun K Mittal, Thomas Halborg, Rafail A Kotronias, David Adlam, Bhavik Modi, Jonathan Rodrigues, Nicholas Screaton, Attila Kardos, John P Greenwood, Nikant Sabharwal, Giovanni Luigi De
Published in: The Lancet, Issue 403, 2024, Page(s) 2606-2618, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(24)00596-8

Pericoronary Adipose Tissue Imaging and the Need for Standardized Measurement of Coronary Inflammation

Author(s): Charalambos Antoniades, Kenneth Chan
Published in: JACC: Cardiovascular Imaging, Issue 18, 2025, Page(s) 895-898, ISSN 1936-878X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmg.2025.06.012

Anticoagulation in Patients With Device‐Detected Atrial Fibrillation With and Without a Prior Stroke or Transient Ischemic Attack: The NOAH‐AFNET 6 Trial

Author(s): Hans Christoph Diener, Nina Becher, Susanne Sehner, Tobias Toennis, Emanuele Bertaglia, Carina Blomstrom‐Lundqvist, Axel Brandes, Vincent Beuger, Melanie Calvert, A. John Camm, Gregory Chlouverakis, Gheorghe‐Andrei Dan, Wolfgang Dichtl, Alexander Fierenz, Andreas Goette, Joris R. de Groot, Astrid Hermans, Gregory Y. H. Lip, Andrzej Lubinski, Eloi Marijon, Béla Merkely, Lluís Mont, Julius Nik
Published in: Journal of the American Heart Association, Issue 13, 2024, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.124.036429

Comparison of cardiac troponin assays reveals assay-specific sensitivities in a clinical model of very acute myocardial injury

Author(s): Julius Obergassel, Marc D Lemoine, Laura C Sommerfeld, Jan L Rieß, Salah Al-Aqili, Sandro J Jäckle, Laura Rottner, Andreas Rillig, Andreas Metzner, Nils A Sörensen, Larissa Fabritz, Thomas Renné, Raphael Twerenbold, Stefan Blankenberg, Tanja Zeller, Paulus Kirchhof, Johannes T Neumann
Published in: European Heart Journal: Acute Cardiovascular Care, Issue 14, 2025, Page(s) 552-561, ISSN 2048-8726
Publisher: SAGE Publications Ltd
DOI: 10.1093/ehjacc/zuaf064

Emerging biomarkers for vascular remodeling in volume and pressure overload in a cardiology cohort

Author(s): Dora Csengeri, Daniel Engler, Patricia Schlieker, Amelie H. Ohlrogge, Niklas Schofer, Daniel Kalbacher, Larissa Fabritz, André Ziegler, Stefan Blankenberg, Paulus Kirchhof, Tanja Zeller, Renate B. Schnabel
Published in: IJC Heart & Vasculature, Issue 60, 2025, Page(s) 101768, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2025.101768

Prognostic Value of Strain by Speckle Tracking Echocardiography in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy

Author(s): Areej Aljehani, Kyaw Zaw Win, Shanat Baig, Manish Kalla, Bode Ensam, Larissa Fabritz, Richard P. Steeds
Published in: Journal of Cardiovascular Development and Disease, Issue 11, 2025, Page(s) 388, ISSN 2308-3425
Publisher: MDPI AG
DOI: 10.3390/jcdd11120388

Does atrial fibrillation ablation prevent cardiovascular death, stroke, and heart failure events?

Author(s): Paulus Kirchhof, Abdul Shokor Parwani, Niklas Schenker
Published in: Heart Rhythm, Issue 22, 2025, Page(s) 2224-2226, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.11.005

Enhanced Ca2+-Driven Arrhythmogenic Events in Female Patients With Atrial Fibrillation

Author(s): Xianwei Zhang, Yixuan Wu, Charlotte E.R. Smith, William E. Louch, Stefano Morotti, Dobromir Dobrev, Eleonora Grandi, Haibo Ni
Published in: JACC: Clinical Electrophysiology, Issue 10, 2024, Page(s) 2371-2391, ISSN 2405-500X
Publisher: Elsevier BV
DOI: 10.1016/j.jacep.2024.07.020

Lateral Atrial Expression Patterns Provide Insights into Local Transcription Disequilibrium Contributing to Disease Susceptibility

Author(s): Aaron Isaacs, Stef Zeemering, Joris Winters, Montserrat Batlle, Elham Bidar, Bas Boukens, Barbara Casadei, Winnie Chua, Harry J.G.M. Crijns, Larissa Fabritz, Eduard Guasch, Stephane N. Hatem, Ben Hermans, Stefan Kääb, Michal Kawczynski, Bart Maesen, Jos Maessen, Lluis Mont, Moritz F. Sinner, Reza Wakili, Sander Verheule, Paulus Kirchhof, Ulrich Schotten, Monika Stoll
Published in: Circulation: Genomic and Precision Medicine, Issue 18, 2025, ISSN 2574-8300
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/circgen.124.004594

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy

Author(s): Goette A, Borof K, Breithardt G, et al.
Published in: JACC, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2022.04.058

Association of atrial fibrillation burden and clinical profile with blood biomarkers: Results from the ISOLATION Ablation Cohort

Author(s): Zarina Habibi, Dominique V.M. Verhaert, Konstanze Betz, Ben J.M. Hermans, Joris Winters, Suzanne A.M. Philippens, Sevasti-Maria Chaldoupi, Bart Maesen, Jos G. Maessen, Aaron Isaacs, Sjoerd W. Westra, Robin Nijveldt, Ludovic Gillet, Ursula-Henrike Wienhues-Thelen, Merlin Koehler, Stef Zeemering, Kevin Vernooy, Dominik Linz, Ulrich Schotten
Published in: Heart Rhythm O2, Issue 6, 2025, Page(s) 661-670, ISSN 2666-5018
Publisher: Elsevier BV
DOI: 10.1016/j.hroo.2025.02.017

A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation

Author(s): Theresa Poppenborg, Arnela Saljic, Florian Bruns, Issam Abu-Taha, Dobromir Dobrev, Anke C. Fender
Published in: Journal of Molecular and Cellular Cardiology, Issue 202, 2025, Page(s) 13-23, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2025.02.011

Sex and atrial fibrillation-associated risk estimation and management

Author(s): Anke C. Fender, Florian Bruns, Dobromir Dobrev
Published in: International Journal of Cardiology, Issue 423, 2025, Page(s) 133000, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2025.133000

Recent highlights from the International Journal of Cardiology Heart and Vasculature: cardio-oncology

Author(s): Anke Fender, Florian Bruns, Dobromir Dobrev
Published in: IJC Heart & Vasculature, Issue 60, 2025, Page(s) 101780, ISSN 2352-9067
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2025.101780

Rotors anchored by refractory islands drive Torsades de Pointes in an experimental model of electrical storm

Author(s): Yamazaki M, Tomii N, Tsuneyama K, Takanari H, Niwa R, Honjo H, Kodama I, Arafune T, Makita N, Sakuma I, Dobrev D, Nattel S, Tsuji Y
Published in: Heart Rhythm, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2021.10.012

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Author(s): Gawałko M, Agbaedeng TA, Saljic A, Müller DN, Wilck N, Schanabel R, Penders J, Rienstra M, van Gelder I, Jespersen T, Schotten U, Crijns HJGM, Kalman JM, Sanders P, Nattel S, Dobrev D, Linz D
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab292

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank

Author(s): Kany S, Cardoso VR, Bravo L, et al.
Published in: BMJ Heart, 2022, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2022-321196

Benchmark for Quantitative Global and Redox Proteomics Analysis by Combining Protein-Aggregation Capture and Data Independent Acquisition

Author(s): Ana Martinez-Val, Samuel Lozano-Juárez, Jorge Lumbreras Burgueño, Irene Rodríguez, Marinela Couselo-Seijas, Ana Simón-Chica, Carlos Galán-Arriola, Rodrigo Fernández-Jiménez, Estefanía Núñez, Inmaculada Jorge, David Filgueiras-Rama, Borja Ibáñez, Jesús Vázquez
Published in: Analytical Chemistry, Issue 97, 2025, Page(s) 19730-19741, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.5c03294

Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials

Author(s): Renate B Schnabel, Juan Benezet-Mazuecos, Nina Becher, William F McIntyre, Alexander Fierenz, Shun Fu Lee, Andreas Goette, Dan Atar, Emanuele Bertaglia, Alexander P Benz, Gregory Chlouverakis, David H Birnie, Wolfgang Dichtl, Carina Blomstrom-Lundqvist, A John Camm, Julia W Erath, Emmanuel Simantirakis, Valentina Kutyifa, Gregory Y H Lip, Philippe Mabo, Eloi Marijon, Lena Rivard, Ulrich Schotten,
Published in: European Heart Journal, Issue 45, 2024, Page(s) 4902-4916, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae596

Coronary computed tomography angiography in Greek clinical practice: Data from a contemporary, real-world multicenter cohort [coronary computed tomography angiography – Greece (COCOA-GR)]

Author(s): Alexios S. Antonopoulos, Spyridon Simantiris, Georgios Benetos, Charalampos Papastamos, Nikolaos Axypolitos, Pete Tomlins, Aikaterini Pappa, Kalliopi Grigoriou, Ioannis Andrikou, Dimitrios Terentes-Printzios, Dimitrios Manos, Panagiotis Korkonikitas, Dimitrios Papandreou, Spyridoula Katsilouli, Olga Karapanagiotou, Ioannis Skoumas, Konstantinos Toutouzas, Thomas Vrachliotis, Dimitrios Tousoulis, K
Published in: Atherosclerosis, Issue 407, 2025, Page(s) 119777, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2025.119777

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study

Author(s): Larissa Fabritz, Christoph Al-Taie, Katrin Borof, Günter Breithardt, A John Camm, Harry J G M Crijns, Victor Roth Cardoso, Winnie Chua, Silke van Elferen, Lars Eckardt, Georgios Gkoutos, Andreas Goette, Eduard Guasch, Stéphane Hatem, Andreas Metzner, Lluís Mont, Vaishnavi Ameya Murukutla, Julius Obergassel, Andreas Rillig, Moritz F Sinner, Renate B Schnabel, Ulrich Schotten, Laura C Sommerfeld,
Published in: European Heart Journal, Issue 45, 2024, Page(s) 5002-5019, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehae611

Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy

Author(s): Dan Atar, Christophe Vandenbriele, Stefan Agewall, Bruna Gigante, Andreas Goette, Diana A Gorog, Pål A Holme, Konstantin A Krychtiuk, Bianca Rocca, Jolanta M Siller-Matula, Marco Valgimigli, Andrea Rubboli, Robert Klamroth
Published in: European Heart Journal - Cardiovascular Pharmacotherapy, Issue 11, 2025, Page(s) 275-289, ISSN 2055-6837
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjcvp/pvaf006

Late diagnosis of Marfan syndrome is associated with unplanned aortic surgery and cardiovascular death

Author(s): Jason Claus, Lauritz Schoof, Thomas S. Mir, Anna Lena Kammal, Gerhard Schön, Kerstin Kutsche, Christian-Alexander Behrendt, Klaus Kallenbach, Tilo Kölbel, Christian Kubisch, Till Joscha Demal, Johannes Petersen, Jens Brickwedel, Michael Hübler, Christian Detter, Paulus Kirchhof, Eike Sebastian Debus, Meike Rybczynski, Yskert von Kodolitsch
Published in: The Journal of Thoracic and Cardiovascular Surgery, Issue 169, 2025, Page(s) 1201-1209.e33, ISSN 0022-5223
Publisher: Mosby Inc.
DOI: 10.1016/j.jtcvs.2024.09.016

Chronic total occlusion of infarct-related artery: A bystander or a risk factor of electrical storm?

Author(s): Tsuji Y, Dobrev D
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101051

From translation to integration: how to approach the complexity of atrial fibrillation mechanisms

Author(s): Schotten U.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab168

Atrial fibrillation and stroke: are we looking in the right direction?

Author(s): Hatem SN, Cohen A.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab341

Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance

Author(s): XiaoYan Qi, Feng Xiong, Jiening Xiao, Kalai Mangai Muthukumarasamy, Yasemin Altuntas, Yuan Zhong, Issam Abu-Taha, Florian Bruns, Marcel Tekook, Markus Kamler, Louis Villeneuve, Anna Nozza, Martin Sirois, Jason Karch, Philippe Pasdois, Donald M. Bers, Dobromir Dobrev, Stanley Nattel
Published in: 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.29.635508

Mechanistic Insights into Sex Differences in Atrial Electrophysiology and Arrhythmia Vulnerability through Sex-specific Computational Models

Author(s): Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi
Published in: 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.08.18.670886

Automated Pipeline for Regional Epicardial Adipose Tissue Distribution Analysis in the Left Atrium

Author(s): Èric Lluch, Eduardo Castañeda, Maximilian E. R. Weiss, Anamaria Vizitiu, Athira Jacob, Jitin Jami, Chloé Audigier, Felix Meister, Viorel Mihalef, Tiziano Passerini
Published in: Lecture Notes in Computer Science, Statistical Atlases and Computational Models of the Heart. Workshop, CMRxRecon and MBAS Challenge Papers., 2025, Page(s) 323-333
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-87756-8_32

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