Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation

Project Information

MAESTRIA

Grant agreement ID: 965286

DOI 10.3030/965286

EC signature date 21 January 2021

Start date 1 March 2021

End date 28 February 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 14 520 311,25

EU contribution € 13 915 311,25

Coordinated by

SORBONNE UNIVERSITE
France

Deliverables

Documents, reports (8)

Authorisations for hosting data from related databases, regulatory and Ethical aspects

Authorisations for hosting data from related databases regulatory and Ethical aspects

Project management handbook
Report on the feasibility and legal aspects of aggregating health data from different countries
SOPs for ECG, echocardiography, MRI and CT imaging acquisition, processing and storage of whole blood, EDTA plasma, SST serum

SOPs for ECG echocardiography MRI and CT imaging acquisition processing and storage of whole blood EDTA plasma SST serum

MAESTRIA AF Ablation 1st study subject approvals package
MAESTRIA-AFNET 10 1st study subject approvals package

MAESTRIAAFNET 10 1st study subject approvals package

Detailed dissemination plan
CATS-AF 1st study subject approvals package

CATSAF 1st study subject approvals package

Publications

Peer reviewed articles (36)

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis,

Author(s): Zeemering S, Isaacs A, Winters J, et al.
Published in: Zeemering S, Isaacs A, Winters J, et al., 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2022.08.019

Great Debate: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting should be limited to 1 week

Author(s): Galli M, Agewall S, Andreotti F, et al.
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac294

Association between retinopathy and development of long-term cardiovascular events. Results of the follow-up of RETICARD cohort

Author(s): Aguila Gordo D, Marina-Breysse M, Piqueras Flores J, et al.
Published in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab061.218

Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences

Author(s): Goette A, Lendeckel U
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10102605

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

Author(s): Maesen B, Verhuele S, Zeemering S, et al.
Published in: EP Europace, 2022, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac026

Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti.

Author(s): Heijman J, Dobrev D.
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac357

Fat chance for POAF? Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation

Author(s): Gawałko M, Dobrev D
Published in: Int J Cardiol Heart Vasc, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101000

The virtual patient – Estimating the health utility of aspirin in simulated populations

Author(s): Fender AC, Dobrev D
Published in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100857

Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology

Author(s): Chaumont C, Suffee N, Gandjbakhch E, et al.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab213

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

Author(s): Gawalko M, Saljic A, Li N, et al.
Published in: Cardiovascular Research, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac093

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Author(s): Nattel S, Sager PT, Hüser J, Heijman J, Dobrev D.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab093

Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice

Author(s): Suffee N, Baptista E, Piquereau J, et al.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab367

Does gut microbiota affect atrial rhythm? Causalities & Speculations

Author(s): Linz D, Gawałko M, Sanders P, Penders J, Li N, Nattel S, Dobrev D
Published in: Eur Heart J, 2021, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab467

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

Author(s): Salic A, Heijman J, Dobrev D
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084096

Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome.

Author(s): Manuel AIM, Jalife J, et al.
Published in: Cardiovascular Research, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac118

Common disease-promoting signaling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences

Author(s): Keefe JA, Wehrens XT, Dobrev D
Published in: Cardiovascular Research, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac107

Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge

Author(s): Linz D, Linz B, Dobrev D, Baumert M, Hendriks JM, Pepin JL, Jespersen T
Published in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100843

Minding the gap – Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines

Author(s): Fender AC, Bruns F, Dobrev D
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2021.12.030

Challenges and Opportunities in Improving the Management of Atrial Fibrillation: Recent Research Advances and their Clinical Translation

Author(s): Nattel S, Lip GYH, Filgueiras-Rama D, Dobrev D
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab170

Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Author(s): Blandin CE, Gravez BJ, Hatem SN, Balse E.
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10092417

Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation – unmet clinical needs

Author(s): Bruns F, Dobrev D, Fender AC
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.08.019

Proteomics: a promising approach to discover new biomarkers for atrial fibrillation

Author(s): Song J, Dobrev D, Li N
Published in: Int J Cardiol, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2021.10.135

Pathophysiological differences between atrial fibrillation subgoups: Is there a fibrillatory-induced atherosclerotic disease progression?

Author(s): Goette A.
Published in: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100892

Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?

Author(s): Dobrev D, Dudley SC.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab124

Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats

Author(s): Bukowska A, Nikonova Y, Wolke C, et al.
Published in: IJC Heart & Vasculature, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101088

Inflammatory signaling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

Author(s): Dobrev D, Heijman J, Hiram R, Li N, Nattel S
Published in: Nat Rev Cardiol, 2022, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-022-00759-w

Stretching the limits of antiarrhythmic drug therapy: the promise of small-conductance calcium-activated potassium channel blockers

Author(s): Heijman J, Rahm AK, Dobrev D
Published in: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100924

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference 

Author(s): Schnabel RB, Marinelli EA, Arbelo E, et al.
Published in: EP Europace, 2022, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac062

Childhood infection and modern malnutrition: do childhood infections create an inflammatory foundation for atherosclerosis in adult life?

Author(s): Fender A, Dobrev D
Published in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100840

TGF-β1-induced endothelial-to-mesenchymal transition: a potential contributor to atrial fibrillation promoting fibrotic remodeling?

Author(s): Saljic A, Grandi E, Dobrev D
Published in: J Clin Invest, 2022, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci161070

Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation?

Author(s): Cai M, Schotten U, Dobrev D, Heijman J.
Published in: International Journal of Cardiology, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.07.027

Assessment of atrial function by echocardiography: can this be used to assess the arrhythmogenic atrial substrate?

Author(s): Bruns F, Dobrev D
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2022.05.070

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy

Author(s): Goette A, Borof K, Breithardt G, et al.
Published in: JACC, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2022.04.058

Rotors anchored by refractory islands drive Torsades de Pointes in an experimental model of electrical storm

Author(s): Yamazaki M, Tomii N, Tsuneyama K, Takanari H, Niwa R, Honjo H, Kodama I, Arafune T, Makita N, Sakuma I, Dobrev D, Nattel S, Tsuji Y
Published in: Heart Rhythm, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2021.10.012

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Author(s): Gawałko M, Agbaedeng TA, Saljic A, Müller DN, Wilck N, Schanabel R, Penders J, Rienstra M, van Gelder I, Jespersen T, Schotten U, Crijns HJGM, Kalman JM, Sanders P, Nattel S, Dobrev D, Linz D
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab292

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank

Author(s): Kany S, Cardoso VR, Bravo L, et al.
Published in: BMJ Heart, 2022, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2022-321196

Non-peer reviewed articles (2)

Chronic total occlusion of infarct-related artery: A bystander or a risk factor of electrical storm?

Author(s): Tsuji Y, Dobrev D
Published in: Int J Cardiol, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101051

From translation to integration: how to approach the complexity of atrial fibrillation mechanisms

Author(s): Schotten U.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab168

Conference proceedings (1)

Atrial fibrillation and stroke: are we looking in the right direction?

Author(s): Hatem SN, Cohen A.
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab341