Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation

Informations projet

MAESTRIA

N° de convention de subvention: 965286

DOI

10.3030/965286

Date de signature de la CE 21 Janvier 2021

Date de début 1 Mars 2021

Date de fin 28 Février 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 14 520 311,25

Contribution de l’UE

€ 13 915 311,25

Coordonné par

SORBONNE UNIVERSITE
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (14)

MRI-HiRA 1st study subject approvals package
Authorisations for hosting data from related databases, regulatory and Ethical aspects

Authorisations for hosting data from related databases regulatory and Ethical aspects

MAESTRIA AF Ablation mid-term recruitment report
Project management handbook
Report on the feasibility and legal aspects of aggregating health data from different countries
SOPs for ECG, echocardiography, MRI and CT imaging acquisition, processing and storage of whole blood, EDTA plasma, SST serum

SOPs for ECG echocardiography MRI and CT imaging acquisition processing and storage of whole blood EDTA plasma SST serum

CATS-AF mid-term recruitment report
MRI-HiRA report on status of posting results
MAESTRIA AF Ablation 1st study subject approvals package
MAESTRIA-AFNET 10 1st study subject approvals package

MAESTRIAAFNET 10 1st study subject approvals package

MAESTRIA-AFNET 10 mid-term recruitment report
MRI-HiRA mid-term recruitment report
Detailed dissemination plan
CATS-AF 1st study subject approvals package

CATSAF 1st study subject approvals package

Demonstrators, pilots, prototypes (1)

Demonstrable prototype of Patient-specific Digital Twin of the atria

Publications

Peer reviewed articles (36)

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis,

Auteurs: Zeemering S, Isaacs A, Winters J, et al.
Publié dans: Zeemering S, Isaacs A, Winters J, et al., 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.hrthm.2022.08.019

Great Debate: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting should be limited to 1 week

Auteurs: Galli M, Agewall S, Andreotti F, et al.
Publié dans: European Heart Journal, 2022, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehac294

Association between retinopathy and development of long-term cardiovascular events. Results of the follow-up of RETICARD cohort

Auteurs: Aguila Gordo D, Marina-Breysse M, Piqueras Flores J, et al.
Publié dans: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Éditeur: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab061.218

Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences

Auteurs: Goette A, Lendeckel U
Publié dans: Cells, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10102605

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

Auteurs: Maesen B, Verhuele S, Zeemering S, et al.
Publié dans: EP Europace, 2022, ISSN 1099-5129
Éditeur: Oxford University Press
DOI: 10.1093/europace/euac026

Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti.

Auteurs: Heijman J, Dobrev D.
Publié dans: European Heart Journal, 2022, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehac357

Fat chance for POAF? Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation

Auteurs: Gawałko M, Dobrev D
Publié dans: Int J Cardiol Heart Vasc, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101000

The virtual patient – Estimating the health utility of aspirin in simulated populations

Auteurs: Fender AC, Dobrev D
Publié dans: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100857

Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology

Auteurs: Chaumont C, Suffee N, Gandjbakhch E, et al.
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab213

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

Auteurs: Gawalko M, Saljic A, Li N, et al.
Publié dans: Cardiovascular Research, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvac093

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Auteurs: Nattel S, Sager PT, Hüser J, Heijman J, Dobrev D.
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab093

Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice

Auteurs: Suffee N, Baptista E, Piquereau J, et al.
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab367

Does gut microbiota affect atrial rhythm? Causalities & Speculations

Auteurs: Linz D, Gawałko M, Sanders P, Penders J, Li N, Nattel S, Dobrev D
Publié dans: Eur Heart J, 2021, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehab467

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

Auteurs: Salic A, Heijman J, Dobrev D
Publié dans: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084096

Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome.

Auteurs: Manuel AIM, Jalife J, et al.
Publié dans: Cardiovascular Research, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvac118

Common disease-promoting signaling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences

Auteurs: Keefe JA, Wehrens XT, Dobrev D
Publié dans: Cardiovascular Research, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvac107

Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge

Auteurs: Linz D, Linz B, Dobrev D, Baumert M, Hendriks JM, Pepin JL, Jespersen T
Publié dans: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100843

Minding the gap – Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines

Auteurs: Fender AC, Bruns F, Dobrev D
Publié dans: Int J Cardiol, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2021.12.030

Challenges and Opportunities in Improving the Management of Atrial Fibrillation: Recent Research Advances and their Clinical Translation

Auteurs: Nattel S, Lip GYH, Filgueiras-Rama D, Dobrev D
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab170

Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Auteurs: Blandin CE, Gravez BJ, Hatem SN, Balse E.
Publié dans: Cells, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10092417

Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation – unmet clinical needs

Auteurs: Bruns F, Dobrev D, Fender AC
Publié dans: Int J Cardiol, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2022.08.019

Proteomics: a promising approach to discover new biomarkers for atrial fibrillation

Auteurs: Song J, Dobrev D, Li N
Publié dans: Int J Cardiol, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2021.10.135

Pathophysiological differences between atrial fibrillation subgoups: Is there a fibrillatory-induced atherosclerotic disease progression?

Auteurs: Goette A.
Publié dans: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100892

Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?

Auteurs: Dobrev D, Dudley SC.
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab124

Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats

Auteurs: Bukowska A, Nikonova Y, Wolke C, et al.
Publié dans: IJC Heart & Vasculature, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101088

Inflammatory signaling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

Auteurs: Dobrev D, Heijman J, Hiram R, Li N, Nattel S
Publié dans: Nat Rev Cardiol, 2022, ISSN 1759-5002
Éditeur: Nature Publishing Group
DOI: 10.1038/s41569-022-00759-w

Stretching the limits of antiarrhythmic drug therapy: the promise of small-conductance calcium-activated potassium channel blockers

Auteurs: Heijman J, Rahm AK, Dobrev D
Publié dans: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100924

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference 

Auteurs: Schnabel RB, Marinelli EA, Arbelo E, et al.
Publié dans: EP Europace, 2022, ISSN 1099-5129
Éditeur: Oxford University Press
DOI: 10.1093/europace/euac062

Childhood infection and modern malnutrition: do childhood infections create an inflammatory foundation for atherosclerosis in adult life?

Auteurs: Fender A, Dobrev D
Publié dans: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100840

TGF-β1-induced endothelial-to-mesenchymal transition: a potential contributor to atrial fibrillation promoting fibrotic remodeling?

Auteurs: Saljic A, Grandi E, Dobrev D
Publié dans: J Clin Invest, 2022, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci161070

Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation?

Auteurs: Cai M, Schotten U, Dobrev D, Heijman J.
Publié dans: International Journal of Cardiology, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2022.07.027

Assessment of atrial function by echocardiography: can this be used to assess the arrhythmogenic atrial substrate?

Auteurs: Bruns F, Dobrev D
Publié dans: Int J Cardiol, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcard.2022.05.070

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy

Auteurs: Goette A, Borof K, Breithardt G, et al.
Publié dans: JACC, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2022.04.058

Rotors anchored by refractory islands drive Torsades de Pointes in an experimental model of electrical storm

Auteurs: Yamazaki M, Tomii N, Tsuneyama K, Takanari H, Niwa R, Honjo H, Kodama I, Arafune T, Makita N, Sakuma I, Dobrev D, Nattel S, Tsuji Y
Publié dans: Heart Rhythm, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.hrthm.2021.10.012

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Auteurs: Gawałko M, Agbaedeng TA, Saljic A, Müller DN, Wilck N, Schanabel R, Penders J, Rienstra M, van Gelder I, Jespersen T, Schotten U, Crijns HJGM, Kalman JM, Sanders P, Nattel S, Dobrev D, Linz D
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab292

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank

Auteurs: Kany S, Cardoso VR, Bravo L, et al.
Publié dans: BMJ Heart, 2022, ISSN 1355-6037
Éditeur: BMJ Publishing Group
DOI: 10.1136/heartjnl-2022-321196

Non-peer reviewed articles (2)

Chronic total occlusion of infarct-related artery: A bystander or a risk factor of electrical storm?

Auteurs: Tsuji Y, Dobrev D
Publié dans: Int J Cardiol, 2022, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101051

From translation to integration: how to approach the complexity of atrial fibrillation mechanisms

Auteurs: Schotten U.
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab168

Conference proceedings (1)

Atrial fibrillation and stroke: are we looking in the right direction?

Auteurs: Hatem SN, Cohen A.
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab341