Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation

Informazioni relative al progetto

MAESTRIA

ID dell’accordo di sovvenzione: 965286

DOI

10.3030/965286

Data della firma CE 21 Gennaio 2021

Data di avvio 1 Marzo 2021

Data di completamento 28 Febbraio 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 14 520 311,25

Contributo UE

€ 13 915 311,25

Coordinato da

SORBONNE UNIVERSITE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (14)

MRI-HiRA 1st study subject approvals package
Authorisations for hosting data from related databases, regulatory and Ethical aspects

Authorisations for hosting data from related databases regulatory and Ethical aspects

MAESTRIA AF Ablation mid-term recruitment report
Project management handbook
Report on the feasibility and legal aspects of aggregating health data from different countries
SOPs for ECG, echocardiography, MRI and CT imaging acquisition, processing and storage of whole blood, EDTA plasma, SST serum

SOPs for ECG echocardiography MRI and CT imaging acquisition processing and storage of whole blood EDTA plasma SST serum

CATS-AF mid-term recruitment report
MRI-HiRA report on status of posting results
MAESTRIA AF Ablation 1st study subject approvals package
MAESTRIA-AFNET 10 1st study subject approvals package

MAESTRIAAFNET 10 1st study subject approvals package

MAESTRIA-AFNET 10 mid-term recruitment report
MRI-HiRA mid-term recruitment report
Detailed dissemination plan
CATS-AF 1st study subject approvals package

CATSAF 1st study subject approvals package

Demonstrators, pilots, prototypes (1)

Demonstrable prototype of Patient-specific Digital Twin of the atria

Pubblicazioni

Peer reviewed articles (36)

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis,

Autori: Zeemering S, Isaacs A, Winters J, et al.
Pubblicato in: Zeemering S, Isaacs A, Winters J, et al., 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2022.08.019

Great Debate: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting should be limited to 1 week

Autori: Galli M, Agewall S, Andreotti F, et al.
Pubblicato in: European Heart Journal, 2022, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac294

Association between retinopathy and development of long-term cardiovascular events. Results of the follow-up of RETICARD cohort

Autori: Aguila Gordo D, Marina-Breysse M, Piqueras Flores J, et al.
Pubblicato in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Editore: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab061.218

Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences

Autori: Goette A, Lendeckel U
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10102605

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

Autori: Maesen B, Verhuele S, Zeemering S, et al.
Pubblicato in: EP Europace, 2022, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euac026

Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti.

Autori: Heijman J, Dobrev D.
Pubblicato in: European Heart Journal, 2022, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac357

Fat chance for POAF? Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation

Autori: Gawałko M, Dobrev D
Pubblicato in: Int J Cardiol Heart Vasc, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101000

The virtual patient – Estimating the health utility of aspirin in simulated populations

Autori: Fender AC, Dobrev D
Pubblicato in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100857

Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology

Autori: Chaumont C, Suffee N, Gandjbakhch E, et al.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab213

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

Autori: Gawalko M, Saljic A, Li N, et al.
Pubblicato in: Cardiovascular Research, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac093

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Autori: Nattel S, Sager PT, Hüser J, Heijman J, Dobrev D.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab093

Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice

Autori: Suffee N, Baptista E, Piquereau J, et al.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab367

Does gut microbiota affect atrial rhythm? Causalities & Speculations

Autori: Linz D, Gawałko M, Sanders P, Penders J, Li N, Nattel S, Dobrev D
Pubblicato in: Eur Heart J, 2021, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehab467

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

Autori: Salic A, Heijman J, Dobrev D
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084096

Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome.

Autori: Manuel AIM, Jalife J, et al.
Pubblicato in: Cardiovascular Research, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac118

Common disease-promoting signaling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences

Autori: Keefe JA, Wehrens XT, Dobrev D
Pubblicato in: Cardiovascular Research, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac107

Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge

Autori: Linz D, Linz B, Dobrev D, Baumert M, Hendriks JM, Pepin JL, Jespersen T
Pubblicato in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100843

Minding the gap – Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines

Autori: Fender AC, Bruns F, Dobrev D
Pubblicato in: Int J Cardiol, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2021.12.030

Challenges and Opportunities in Improving the Management of Atrial Fibrillation: Recent Research Advances and their Clinical Translation

Autori: Nattel S, Lip GYH, Filgueiras-Rama D, Dobrev D
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab170

Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Autori: Blandin CE, Gravez BJ, Hatem SN, Balse E.
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10092417

Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation – unmet clinical needs

Autori: Bruns F, Dobrev D, Fender AC
Pubblicato in: Int J Cardiol, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2022.08.019

Proteomics: a promising approach to discover new biomarkers for atrial fibrillation

Autori: Song J, Dobrev D, Li N
Pubblicato in: Int J Cardiol, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2021.10.135

Pathophysiological differences between atrial fibrillation subgoups: Is there a fibrillatory-induced atherosclerotic disease progression?

Autori: Goette A.
Pubblicato in: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100892

Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?

Autori: Dobrev D, Dudley SC.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab124

Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats

Autori: Bukowska A, Nikonova Y, Wolke C, et al.
Pubblicato in: IJC Heart & Vasculature, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101088

Inflammatory signaling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

Autori: Dobrev D, Heijman J, Hiram R, Li N, Nattel S
Pubblicato in: Nat Rev Cardiol, 2022, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-022-00759-w

Stretching the limits of antiarrhythmic drug therapy: the promise of small-conductance calcium-activated potassium channel blockers

Autori: Heijman J, Rahm AK, Dobrev D
Pubblicato in: IJC Heart & Vasculature, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100924

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference 

Autori: Schnabel RB, Marinelli EA, Arbelo E, et al.
Pubblicato in: EP Europace, 2022, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euac062

Childhood infection and modern malnutrition: do childhood infections create an inflammatory foundation for atherosclerosis in adult life?

Autori: Fender A, Dobrev D
Pubblicato in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100840

TGF-β1-induced endothelial-to-mesenchymal transition: a potential contributor to atrial fibrillation promoting fibrotic remodeling?

Autori: Saljic A, Grandi E, Dobrev D
Pubblicato in: J Clin Invest, 2022, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci161070

Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation?

Autori: Cai M, Schotten U, Dobrev D, Heijman J.
Pubblicato in: International Journal of Cardiology, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2022.07.027

Assessment of atrial function by echocardiography: can this be used to assess the arrhythmogenic atrial substrate?

Autori: Bruns F, Dobrev D
Pubblicato in: Int J Cardiol, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2022.05.070

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy

Autori: Goette A, Borof K, Breithardt G, et al.
Pubblicato in: JACC, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2022.04.058

Rotors anchored by refractory islands drive Torsades de Pointes in an experimental model of electrical storm

Autori: Yamazaki M, Tomii N, Tsuneyama K, Takanari H, Niwa R, Honjo H, Kodama I, Arafune T, Makita N, Sakuma I, Dobrev D, Nattel S, Tsuji Y
Pubblicato in: Heart Rhythm, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2021.10.012

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Autori: Gawałko M, Agbaedeng TA, Saljic A, Müller DN, Wilck N, Schanabel R, Penders J, Rienstra M, van Gelder I, Jespersen T, Schotten U, Crijns HJGM, Kalman JM, Sanders P, Nattel S, Dobrev D, Linz D
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab292

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank

Autori: Kany S, Cardoso VR, Bravo L, et al.
Pubblicato in: BMJ Heart, 2022, ISSN 1355-6037
Editore: BMJ Publishing Group
DOI: 10.1136/heartjnl-2022-321196

Non-peer reviewed articles (2)

Chronic total occlusion of infarct-related artery: A bystander or a risk factor of electrical storm?

Autori: Tsuji Y, Dobrev D
Pubblicato in: Int J Cardiol, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101051

From translation to integration: how to approach the complexity of atrial fibrillation mechanisms

Autori: Schotten U.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab168

Conference proceedings (1)

Atrial fibrillation and stroke: are we looking in the right direction?

Autori: Hatem SN, Cohen A.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab341