Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

MRI-HiRA 1st study subject approvals package
Authorisations for hosting data from related databases, regulatory and Ethical aspects

Authorisations for hosting data from related databases regulatory and Ethical aspects

MAESTRIA AF Ablation mid-term recruitment report
Project management handbook
Report on the feasibility and legal aspects of aggregating health data from different countries
SOPs for ECG, echocardiography, MRI and CT imaging acquisition, processing and storage of whole blood, EDTA plasma, SST serum

SOPs for ECG echocardiography MRI and CT imaging acquisition processing and storage of whole blood EDTA plasma SST serum

CATS-AF mid-term recruitment report
MRI-HiRA report on status of posting results
MAESTRIA AF Ablation 1st study subject approvals package
MAESTRIA-AFNET 10 1st study subject approvals package

MAESTRIAAFNET 10 1st study subject approvals package

MAESTRIA-AFNET 10 mid-term recruitment report
MRI-HiRA mid-term recruitment report
Detailed dissemination plan
CATS-AF 1st study subject approvals package

CATSAF 1st study subject approvals package

Demonstrable prototype of Patient-specific Digital Twin of the atria

Pubblicazioni

Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial

Autori: Dipak Kotecha, Karina V. Bunting, Samir Mehta, Philipp Sommer, Maciej Sterliński, Kim Rajappan, Lluís Mont, Eduard Guasch, Serge Boveda, Giuseppe Boriani, Yongzhong Sun, Colinda van Deutekom, Chris P. Gale, Tom J. R. De Potter, Isabelle C. van Gelder, null null, Yann Allali, Asgher Champsi, Thomas Deneke, Kaitlyn Greeley, Benoît Guy-Moyat, Mikael Laredo, Alastair Mobley, Maximina Ventura, Mary
Pubblicato in: Nature Medicine, Numero 31, 2025, Pagina/e 2647-2654, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-025-03751-2

Protease-activated receptor 2 at the intersection of thrombo-inflammation and beyond

Autori: Anke C. Fender, Dobromir Dobrev
Pubblicato in: IJC Heart & Vasculature, Numero 52, 2024, Pagina/e 101403, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101403

Preventative Imaging with Coronary Computed Tomography Angiography

Autori: Alexios S. Antonopoulos, Spyridon Simantiris
Pubblicato in: Current Cardiology Reports, Numero 25, 2023, Pagina/e 1623-1632, ISSN 1523-3782
Editore: Current Science Inc.
DOI: 10.1007/s11886-023-01982-8

Non-neuronal ventricular cardiomyocyte-located nicotinergic acetylcholine receptors cause remodelling and arrhythmias

Autori: Sami F Noujaim, Dobromir Dobrev
Pubblicato in: European Heart Journal, Numero 46, 2025, Pagina/e 1247-1249, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehae845

The thrombin receptor PAR4 supports visceral adipose tissue inflammation

Autori: Sonja Kleeschulte, Vivien Fischinger, Lisa Öhlke, Johannes Bode, Markus Kamler, Dobromir Dobrev, Maria Grandoch, Anke C. Fender
Pubblicato in: Naunyn-Schmiedeberg's Archives of Pharmacology, Numero 397, 2024, Pagina/e 7187-7200, ISSN 0028-1298
Editore: Springer Verlag
DOI: 10.1007/s00210-024-03097-5

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis,

Autori: Zeemering S, Isaacs A, Winters J, et al.
Pubblicato in: Zeemering S, Isaacs A, Winters J, et al., 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2022.08.019

Detectable troponin below the 99th percentile predicts survival in patients undergoing coronary angiography

Autori: Lars Michel, Stefanie Jehn, Iryna Dykun, Markus S. Anker, Peter Ferdinandy, Dobromir Dobrev, Tienush Rassaf, Amir A. Mahabadi, Matthias Totzeck
Pubblicato in: IJC Heart & Vasculature, Numero 52, 2024, Pagina/e 101419, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101419

Heart failure pharmacotherapy and cancer: pathways and pre-clinical/clinical evidence

Autori: Nabil V Sayour, Ágnes M Paál, Pietro Ameri, Wouter C Meijers, Giorgio Minotti, Ioanna Andreadou, Antonella Lombardo, Massimiliano Camilli, Heinz Drexel, Erik Lerkevang Grove, Gheorghe Andrei Dan, Andreea Ivanescu, Anne Grete Semb, Gianluigi Savarese, Dobromir Dobrev, Filippo Crea, Juan-Carlos Kaski, Rudolf A de Boer, Péter Ferdinandy, Zoltán V Varga
Pubblicato in: European Heart Journal, Numero 45, 2024, Pagina/e 1224-1240, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehae105

Great Debate: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting should be limited to 1 week

Autori: Galli M, Agewall S, Andreotti F, et al.
Pubblicato in: European Heart Journal, 2022, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac294

Phenotyping patients with chronic obstructive pulmonary disease and heart failure

Autori: Peter Moritz Becher, Felix Lindberg, Lina Benson, Camilla Hage, Ulf Dahlström, Stephan Rosenkranz, Francesco Cosentino, Giuseppe M.C. Rosano, Stefan Blankenberg, Paulus Kirchhof, Frieder Braunschweig, Lars H. Lund, Gianluigi Savarese
Pubblicato in: ESC Heart Failure, Numero 12, 2025, Pagina/e 900-911, ISSN 2055-5822
Editore: Wiley
DOI: 10.1002/ehf2.15127

Association between retinopathy and development of long-term cardiovascular events. Results of the follow-up of RETICARD cohort

Autori: Aguila Gordo D, Marina-Breysse M, Piqueras Flores J, et al.
Pubblicato in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Editore: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab061.218

Safety and efficacy of long-term sodium channel blocker therapy for early rhythm control: the EAST-AFNET 4 trial

Autori: Andreas Rillig, Lars Eckardt, Katrin Borof, A John Camm, Harry J G M Crijns, Andreas Goette, Günter Breithardt, Marc D Lemoine, Andreas Metzner, Laura Rottner, Ulrich Schotten, Eik Vettorazzi, Karl Wegscheider, Antonia Zapf, Hein Heidbuchel, Stephan Willems, Larissa Fabritz, Renate B Schnabel, Christina Magnussen, Paulus Kirchhof
Pubblicato in: Europace, Numero 26, 2024, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euae121

Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery

Autori: Martijn D. Gilbers, Michal J. Kawczynski, Elham Bidar, Bart Maesen, Aaron Isaacs, Joris Winters, Dominik Linz, Michiel Rienstra, Isabelle van Gelder, Jos G. Maessen, Ulrich Schotten
Pubblicato in: JACC: Clinical Electrophysiology, Numero 10, 2024, Pagina/e 941-955, ISSN 2405-500X
Editore: Elsevier BV
DOI: 10.1016/j.jacep.2024.01.013

Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences

Autori: Goette A, Lendeckel U
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10102605

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

Autori: Maesen B, Verhuele S, Zeemering S, et al.
Pubblicato in: EP Europace, 2022, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euac026

Recent highlights from the International Journal of Cardiology Heart and Vasculature: Spatiotemporal and functional immunoprofiling and its theranostic potential

Autori: Florian Bruns, Dobromir Dobrev, Anke C. Fender
Pubblicato in: IJC Heart & Vasculature, Numero 53, 2024, Pagina/e 101468, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101468

Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation

Autori: Larissa Fabritz, Stephane N. Hatem, Samuel Sossalla
Pubblicato in: Nature Reviews Cardiology, 2025, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-025-01195-2

Anticoagulation with edoxaban in patients with long atrial high-rate episodes ≥24 h

Autori: Nina Becher, Tobias Toennis, Emanuele Bertaglia, Carina Blomström-Lundqvist, Axel Brandes, Nuno Cabanelas, Melanie Calvert, A John Camm, Gregory Chlouverakis, Gheorghe-Andrei Dan, Wolfgang Dichtl, Hans Christoph Diener, Alexander Fierenz, Andreas Goette, Joris R de Groot, Astrid N L Hermans, Gregory Y H Lip, Andrzej Lubinski, Eloi Marijon, Béla Merkely, Lluís Mont, Ann-Kathrin Ozga, Kim Rajappa
Pubblicato in: European Heart Journal, Numero 45, 2024, Pagina/e 837-849, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehad771

Safety and efficacy of amiodarone and dronedarone for early rhythm control in EAST-AFNET 4

Autori: Laura Rottner, Marc D. Lemoine, Lars Eckardt, Katrin Borof, A. John Camm, Andreas Goette, Günter Breithardt, Andreas Metzner, Ulrich Schotten, Antonia Zapf, Hein Heidbüchel, Stephan Willems, Harry Crijns, Renate B. Schnabel, Larissa Fabritz, Christina Magnussen, Andreas Rillig, Paulus Kirchhof
Pubblicato in: Clinical Research in Cardiology, 2025, ISSN 1861-0684
Editore: Steinkopff
DOI: 10.1007/s00392-025-02637-0

Macrophage-mediated IL-6 signaling drives ryanodine receptor–2 calcium leak in postoperative atrial fibrillation

Autori: Joshua A. Keefe, Yuriana Aguilar-Sanchez, J. Alberto Navarro-Garcia, Isabelle Ong, Luge Li, Amelie Paasche, Issam Abu-Taha, Marcel A. Tekook, Florian Bruns, Shuai Zhao, Markus Kamler, Ying H. Shen, Mihail G. Chelu, Na Li, Dobromir Dobrev, Xander H.T. Wehrens
Pubblicato in: Journal of Clinical Investigation, Numero 135, 2025, ISSN 1558-8238
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci187711

Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction

Autori: Larissa Fabritz, Lisa Fortmueller, Katja Gehmlich, Sebastian Kant, Marcel Kemper, Dana Kucerova, Fahima Syeda, Cornelius Faber, Rudolf E. Leube, Paulus Kirchhof, Claudia A. Krusche
Pubblicato in: Biomedicines, Numero 12, 2025, Pagina/e 985, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines12050985

Diabetes and Obesity and Treatment Effect of Early Rhythm Control vs Usual Care in Patients With Atrial Fibrillation

Autori: Andreas Metzner, Stephan Willems, Katrin Borof, Guenther Breithardt, A. John Camm, Harry J. G. M. Crijns, Lars Eckardt, Larissa Fabritz, Nele Gessler, Andreas Goette, Bruno Reissmann, Renate B. Schnabel, Ulrich Schotten, Antonia Zapf, Andreas Rillig, Paulus Kirchhof
Pubblicato in: JAMA Cardiology, Numero 10, 2025, Pagina/e 932, ISSN 2380-6583
Editore: American Medical Association (AMA)
DOI: 10.1001/jamacardio.2025.2374

Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology

Autori: Jose L Merino, Juan Tamargo, Carina Blomström-Lundqvist, Giuseppe Boriani, Harry J G M Crijns, Dobromir Dobrev, Andreas Goette, Stefan H Hohnloser, Gerald V Naccarelli, James A Reiffel, Jacob Tfelt-Hansen, Marcel Martínez-Cossiani, A John Camm, Jesus M Almendral Garrote, Beata Średniawa, Piotr Kułakowski, Irina Savelieva, Tatjana Potpara, Bulent Gorenek, Jose L Zamorano
Pubblicato in: Europace, Numero 27, 2025, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euaf076

Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti.

Autori: Heijman J, Dobrev D.
Pubblicato in: European Heart Journal, 2022, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac357

From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics

Autori: Arnela Saljic, Jordi Heijman, Dobromir Dobrev
Pubblicato in: European Cardiology Review, Numero 19, 2024, ISSN 1758-3756
Editore: Radcliffe Publishing Ltd.
DOI: 10.15420/ecr.2024.41

Outcomes and Management of Stressor-Associated Atrial Fibrillation

Autori: Julian S. Haimovich, Shinwan Kany, Ezimamaka Ajufo, Jason G. Andrade, Emelia J. Benjamin, Jeffrey S. Healey, Paulus Kirchhof, Steven A. Lubitz, William F. McIntyre, Michiel Rienstra, Prashanthan Sanders, Renate B. Schnabel, Patrick T. Ellinor, Shaan Khurshid
Pubblicato in: JACC, Numero 86, 2025, Pagina/e 910-939, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2025.07.031

Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value

Autori: Daniel Enríquez-Vázquez, Jorge G. Quintanilla, Alba García-Escolano, Marinela Couselo-Seijas, Ana Simón-Chica, Peter Lee, José Manuel Alfonso-Almazán, Patricia Mahía, Andrés Redondo-Rodríguez, Javier Modrego, Adriana Ortega-Hernández, Pedro Marcos-Alberca, Ricardo Magni, Enrique Calvo, Rubén Gómez-Gordo, Ping Yan, Giulio La Rosa, José Bustamante-Madrión, Carlos Nicolás Pérez-Garcí
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40196-y

Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes

Autori: Claudia Mittendorff, Issam Abu-Taha, Lena Kassler, Tobias Hustedt, Stephanie Wolf, Johannes G. Bode, Markus Kamler, Dobromir Dobrev, Anke C. Fender
Pubblicato in: Naunyn-Schmiedeberg's Archives of Pharmacology, Numero 398, 2025, Pagina/e 2783-2796, ISSN 0028-1298
Editore: Springer Verlag
DOI: 10.1007/s00210-024-03436-6

Fat chance for POAF? Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation

Autori: Gawałko M, Dobrev D
Pubblicato in: Int J Cardiol Heart Vasc, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101000

Inflammatory gut-heart interactions: Is there a link between inflammatory bowel disease and atrial fibrillation?

Autori: Dobromir Dobrev, Anke C. Fender
Pubblicato in: IJC Heart & Vasculature, Numero 55, 2025, Pagina/e 101537, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101537

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development

Autori: Pablo Gómez-del Arco, Joan Isern, Daniel Jimenez-Carretero, Dolores López-Maderuelo, Rebeca Piñeiro-Sabarís, Fadoua El Abdellaoui-Soussi, Carlos Torroja, María Linarejos Vera-Pedrosa, Mercedes Grima-Terrén, Alberto Benguria, Ana Simón-Chica, Antonio Queiro-Palou, Ana Dopazo, Fátima Sánchez-Cabo, José Jalife, José Luis de la Pompa, David Filgueiras-Rama, Pura Muñoz-Cánoves, Juan Miguel
Pubblicato in: Nature Communications, Numero 15, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-52809-1

Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation and Heart Failure With Diastolic Dysfunction

Autori: Luge Li, Cristian Coarfa, Yue Yuan, Issam Abu-Taha, Xiaolei Wang, Jia Song, Yuying Zeng, Xiaohui Chen, Amrit Koirala, Sandra L. Grimm, Markus Kamler, Lisa K. McClendon, Michelle Tallquist, Stanley Nattel, Dobromir Dobrev, Na Li
Pubblicato in: JACC: Basic to Translational Science, Numero 10, 2025, Pagina/e 101244, ISSN 2452-302X
Editore: Elsevier BV
DOI: 10.1016/j.jacbts.2025.02.004

Recent highlights from the International Journal of Cardiology Heart & Vasculature: Basic and translational research

Autori: Anke C. Fender, Dobromir Dobrev
Pubblicato in: IJC Heart & Vasculature, Numero 53, 2024, Pagina/e 101452, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101452

The virtual patient – Estimating the health utility of aspirin in simulated populations

Autori: Fender AC, Dobrev D
Pubblicato in: Int J Cardiol Heart Vasc, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2021.100857

Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS)

Autori: Andreas Goette, Domenico Corradi, Dobromir Dobrev, Luis Aguinaga, Jose-Angel Cabrera, Sumeet S Chugh, Joris R de Groot, Laurie Soulat-Dufour, Guilherme Fenelon, Stephane N Hatem, Jose Jalife, Yenn-Jiang Lin, Gregory Y H Lip, Gregory M Marcus, Katherine T Murray, Hui-Nam Pak, Ulrich Schotten, Naohiko Takahashi, Takanori Yamaguchi, William A Zoghbi, Stanley Nattel, Lluis Mont, Joseph G Akar, Nazem A
Pubblicato in: Europace, Numero 26, 2025, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euae204

Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

Autori: Joris Winters, Michal J. Kawczynski, Martijn D. Gilbers, Aaron Isaacs, Stef Zeemering, Elham Bidar, Bart Maesen, Michiel Rienstra, Isabelle van Gelder, Sander Verheule, Jos G. Maessen, Ulrich Schotten
Pubblicato in: JACC: Clinical Electrophysiology, Numero 10, 2025, Pagina/e 1326-1340, ISSN 2405-500X
Editore: Elsevier BV
DOI: 10.1016/j.jacep.2024.03.003

Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology

Autori: Chaumont C, Suffee N, Gandjbakhch E, et al.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab213

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

Autori: Gawalko M, Saljic A, Li N, et al.
Pubblicato in: Cardiovascular Research, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac093

Using pericoronary fat attenuation to guide management after coronary interventions

Autori: Charalambos Antoniades, Kenneth Chan
Pubblicato in: EuroIntervention, Numero 21, 2025, Pagina/e e589-e591, ISSN 1969-6213
Editore: Europa Digital & Publishing
DOI: 10.4244/eij-e-25-00018

Lower left ventricular ejection time in <i>MYBPC3</i> variant carriers with overt or subclinical hypertrophic cardiomyopathy

Autori: Isabell Yan, Zoe Möhring, Daniel Reichart, Fanny Kortüm, Julia Münch, Rixa Woitschach, Paulus Kirchhof, Lucie Carrier, Carolyn Y. Ho, Thomas Eschenhagen, Monica Patten
Pubblicato in: ESC Heart Failure, Numero 12, 2025, Pagina/e 3416-3425, ISSN 2055-5822
Editore: Wiley
DOI: 10.1002/ehf2.15346

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Autori: Nattel S, Sager PT, Hüser J, Heijman J, Dobrev D.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab093

Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice

Autori: Suffee N, Baptista E, Piquereau J, et al.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab367

An economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from a German healthcare payer perspective

Autori: Malte Kuniss, Lucy Hillcoat, Joe Moss, Florian Straube, Jason Andrade, Oussama Wazni, Gian Battista Chierchia, Lukas Schwegmann, Eleni Ismyrloglou, Alicia Sale, Stuart Mealing, Tom Bromilow, Emily Lane, Damian Lewis, Andreas Goette
Pubblicato in: BMC Health Services Research, Numero 24, 2024, ISSN 1472-6963
Editore: BioMed Central
DOI: 10.1186/s12913-024-11967-0

Practical approach for atrial cardiomyopathy characterization in patients with atrial fibrillation

Autori: Giulio La Rosa, Carlos A. Morillo, Jorge G. Quintanilla, Adelina Doltra, Lluis Mont, Moisés Rodríguez-Mañero, Andrea Sarkozy, José Luis Merino, David Vivas, Tomás Datino, David Calvo, Nicasio Pérez-Castellano, Julián Pérez-Villacastín, Laurent Fauchier, Gregory Lip, Stéphane N. Hatem, José Jalife, Laura Sanchis, Francisco Marín, David Filgueiras-Rama
Pubblicato in: Revista Española de Cardiología (English Edition), Numero 77, 2024, Pagina/e 656-666, ISSN 1885-5857
Editore: Elsevier BV
DOI: 10.1016/j.rec.2024.02.009

Atrial fibrillation does not equal atrial fibrillation: The important prognostic implications of new-onset atrial fibrillation

Autori: Andreas Goette, Raffaele De Caterina, Joris R. de Groot, Dobromir Dobrev
Pubblicato in: IJC Heart & Vasculature, Numero 56, 2025, Pagina/e 101572, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101572

Ceramides in cardiovascular disease: emerging role as independent risk predictors and novel therapeutic targets

Autori: Roland Klingenberg, Andreas Leiherer, Dobromir Dobrev, Juan C Kaski, Bodo Levkau, Winfried März, Samuel Sossalla, Arnold von Eckardstein, Heinz Drexel
Pubblicato in: Cardiovascular Research, 2025, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvaf093

Recent highlights from the International Journal of Cardiology heart & Vasculature: Comprehensive management of atrial fibrillation

Autori: Dominik Linz, Dobromir Dobrev
Pubblicato in: IJC Heart & Vasculature, Numero 53, 2024, Pagina/e 101478, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2024.101478

General anaesthesia and deep sedation for monopolar pulsed field ablation using a lattice-tip catheter combined with a novel three-dimensional mapping system

Autori: Andreas Rillig, Jun Hirokami, Fabian Moser, Stefano Bordignon, Laura Rottner, Tohoku Shota, Ilaria My, Andrea Urbani, Marc Lemoine, Joseph Kheir, Niklas Schenker, Lukas Urbanek, Katarina Govorov, David Schaack, Julius Obergassel, Jan Riess, Djemail Ismaili, Paulus Kirchhof, Feifan Ouyang, Boris Schmidt, Bruno Reissmann, Kyoung-Ryul Julian Chun, Andreas Metzner
Pubblicato in: Europace, Numero 26, 2024, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euae270

Dronedarone provides effective early rhythm control: post-hoc analysis of the ATHENA trial using EAST-AFNET 4 criteria

Autori: Paulus Kirchhof, A John Camm, Harry J G M Crijns, Jonathan P Piccini, Christian Torp-Pedersen, David S McKindley, Mattias Wieloch, Stefan H Hohnloser
Pubblicato in: Europace, Numero 27, 2025, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euaf080

Does gut microbiota affect atrial rhythm? Causalities & Speculations

Autori: Linz D, Gawałko M, Sanders P, Penders J, Li N, Nattel S, Dobrev D
Pubblicato in: Eur Heart J, 2021, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehab467

Scalable screening for structural heart disease: promises from artificial intelligence-electrocardiogram tools

Autori: Charalambos Antoniades, Kenneth Chan
Pubblicato in: European Heart Journal - Digital Health, Numero 6, 2025, Pagina/e 521-523, ISSN 2634-3916
Editore: Oxford University Press (OUP)
DOI: 10.1093/ehjdh/ztaf048

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

Autori: Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman
Pubblicato in: The Journal of Physiology, 2025, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp288659

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

Autori: Salic A, Heijman J, Dobrev D
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084096

Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts

Autori: Constantin Mann, Carolin van Alst, Simone Gorressen, Rachel Nega, Dobromir Dobrev, Maria Grandoch, Anke C. Fender
Pubblicato in: Naunyn-Schmiedeberg's Archives of Pharmacology, Numero 397, 2024, Pagina/e 7201-7212, ISSN 0028-1298
Editore: Springer Verlag
DOI: 10.1007/s00210-024-03107-6

Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation

Autori: Sean J. Jurgens, Giorgio E.M. Melloni, Shinwan Kany, Larissa Fabritz, Joel T. Rämö, Andreas Goette, Frederick K. Kamanu, David D. Berg, Christina Magnussen, Seung Hoan Choi, Marc P. Bonaca, Robert P. Giugliano, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Philippe Gabriel Steg, Itamar Raz, Eugene Braunwald, James P. Pirruccello, Marc S. Sabatine, Nicholas A. Marston, Paulus Kirchhof
Pubblicato in: JACC, Numero 86, 2025, Pagina/e 738-753, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2025.06.052

Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome.

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Common disease-promoting signaling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences

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Using artificial intelligence to study atherosclerosis from computed tomography imaging: A state-of-the-art review of the current literature

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Minding the gap – Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines

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Recent highlights from the International Journal of Cardiology Heart & Vasculature: cardiometabolic disease

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Spexin Hormone Signaling and Atrial Fibrillation: The Knowns and Unknowns

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Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation – unmet clinical needs

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Proteomics: a promising approach to discover new biomarkers for atrial fibrillation

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Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study

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Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?

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The inflammatory and nutritional status in patients with dilated cardiomyopathy: Different impact for distinct phenogroups?

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Oral anticoagulation in device-detected atrial fibrillation: effects of age, sex, cardiovascular comorbidities, and kidney function on outcomes in the NOAH-AFNET 6 trial

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Childhood infection and modern malnutrition: do childhood infections create an inflammatory foundation for atherosclerosis in adult life?

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Determinants and impact of postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery: Results from the RACE V prospective cohort study

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TGF-β1-induced endothelial-to-mesenchymal transition: a potential contributor to atrial fibrillation promoting fibrotic remodeling?

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Using artificial intelligence to spot heart failure from ECGs: is it prime time?

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Improving antiarrhythmic therapy for patients with atrial fibrillation using common genetic variants

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Pericoronary Adipose Tissue Imaging and the Need for Standardized Measurement of Coronary Inflammation

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Prognostic Value of Strain by Speckle Tracking Echocardiography in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy

Autori: Areej Aljehani, Kyaw Zaw Win, Shanat Baig, Manish Kalla, Bode Ensam, Larissa Fabritz, Richard P. Steeds
Pubblicato in: Journal of Cardiovascular Development and Disease, Numero 11, 2025, Pagina/e 388, ISSN 2308-3425
Editore: MDPI AG
DOI: 10.3390/jcdd11120388

Does atrial fibrillation ablation prevent cardiovascular death, stroke, and heart failure events?

Autori: Paulus Kirchhof, Abdul Shokor Parwani, Niklas Schenker
Pubblicato in: Heart Rhythm, Numero 22, 2025, Pagina/e 2224-2226, ISSN 1547-5271
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2024.11.005

Enhanced Ca2+-Driven Arrhythmogenic Events in Female Patients With Atrial Fibrillation

Autori: Xianwei Zhang, Yixuan Wu, Charlotte E.R. Smith, William E. Louch, Stefano Morotti, Dobromir Dobrev, Eleonora Grandi, Haibo Ni
Pubblicato in: JACC: Clinical Electrophysiology, Numero 10, 2024, Pagina/e 2371-2391, ISSN 2405-500X
Editore: Elsevier BV
DOI: 10.1016/j.jacep.2024.07.020

Lateral Atrial Expression Patterns Provide Insights into Local Transcription Disequilibrium Contributing to Disease Susceptibility

Autori: Aaron Isaacs, Stef Zeemering, Joris Winters, Montserrat Batlle, Elham Bidar, Bas Boukens, Barbara Casadei, Winnie Chua, Harry J.G.M. Crijns, Larissa Fabritz, Eduard Guasch, Stephane N. Hatem, Ben Hermans, Stefan Kääb, Michal Kawczynski, Bart Maesen, Jos Maessen, Lluis Mont, Moritz F. Sinner, Reza Wakili, Sander Verheule, Paulus Kirchhof, Ulrich Schotten, Monika Stoll
Pubblicato in: Circulation: Genomic and Precision Medicine, Numero 18, 2025, ISSN 2574-8300
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/circgen.124.004594

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy

Autori: Goette A, Borof K, Breithardt G, et al.
Pubblicato in: JACC, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2022.04.058

Association of atrial fibrillation burden and clinical profile with blood biomarkers: Results from the ISOLATION Ablation Cohort

Autori: Zarina Habibi, Dominique V.M. Verhaert, Konstanze Betz, Ben J.M. Hermans, Joris Winters, Suzanne A.M. Philippens, Sevasti-Maria Chaldoupi, Bart Maesen, Jos G. Maessen, Aaron Isaacs, Sjoerd W. Westra, Robin Nijveldt, Ludovic Gillet, Ursula-Henrike Wienhues-Thelen, Merlin Koehler, Stef Zeemering, Kevin Vernooy, Dominik Linz, Ulrich Schotten
Pubblicato in: Heart Rhythm O2, Numero 6, 2025, Pagina/e 661-670, ISSN 2666-5018
Editore: Elsevier BV
DOI: 10.1016/j.hroo.2025.02.017

A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation

Autori: Theresa Poppenborg, Arnela Saljic, Florian Bruns, Issam Abu-Taha, Dobromir Dobrev, Anke C. Fender
Pubblicato in: Journal of Molecular and Cellular Cardiology, Numero 202, 2025, Pagina/e 13-23, ISSN 0022-2828
Editore: Academic Press
DOI: 10.1016/j.yjmcc.2025.02.011

Sex and atrial fibrillation-associated risk estimation and management

Autori: Anke C. Fender, Florian Bruns, Dobromir Dobrev
Pubblicato in: International Journal of Cardiology, Numero 423, 2025, Pagina/e 133000, ISSN 0167-5273
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2025.133000

Recent highlights from the International Journal of Cardiology Heart and Vasculature: cardio-oncology

Autori: Anke Fender, Florian Bruns, Dobromir Dobrev
Pubblicato in: IJC Heart & Vasculature, Numero 60, 2025, Pagina/e 101780, ISSN 2352-9067
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2025.101780

Rotors anchored by refractory islands drive Torsades de Pointes in an experimental model of electrical storm

Autori: Yamazaki M, Tomii N, Tsuneyama K, Takanari H, Niwa R, Honjo H, Kodama I, Arafune T, Makita N, Sakuma I, Dobrev D, Nattel S, Tsuji Y
Pubblicato in: Heart Rhythm, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2021.10.012

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Autori: Gawałko M, Agbaedeng TA, Saljic A, Müller DN, Wilck N, Schanabel R, Penders J, Rienstra M, van Gelder I, Jespersen T, Schotten U, Crijns HJGM, Kalman JM, Sanders P, Nattel S, Dobrev D, Linz D
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab292

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank

Autori: Kany S, Cardoso VR, Bravo L, et al.
Pubblicato in: BMJ Heart, 2022, ISSN 1355-6037
Editore: BMJ Publishing Group
DOI: 10.1136/heartjnl-2022-321196

Benchmark for Quantitative Global and Redox Proteomics Analysis by Combining Protein-Aggregation Capture and Data Independent Acquisition

Autori: Ana Martinez-Val, Samuel Lozano-Juárez, Jorge Lumbreras Burgueño, Irene Rodríguez, Marinela Couselo-Seijas, Ana Simón-Chica, Carlos Galán-Arriola, Rodrigo Fernández-Jiménez, Estefanía Núñez, Inmaculada Jorge, David Filgueiras-Rama, Borja Ibáñez, Jesús Vázquez
Pubblicato in: Analytical Chemistry, Numero 97, 2025, Pagina/e 19730-19741, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.5c03294

Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials

Autori: Renate B Schnabel, Juan Benezet-Mazuecos, Nina Becher, William F McIntyre, Alexander Fierenz, Shun Fu Lee, Andreas Goette, Dan Atar, Emanuele Bertaglia, Alexander P Benz, Gregory Chlouverakis, David H Birnie, Wolfgang Dichtl, Carina Blomstrom-Lundqvist, A John Camm, Julia W Erath, Emmanuel Simantirakis, Valentina Kutyifa, Gregory Y H Lip, Philippe Mabo, Eloi Marijon, Lena Rivard, Ulrich Schotten,
Pubblicato in: European Heart Journal, Numero 45, 2024, Pagina/e 4902-4916, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehae596

Coronary computed tomography angiography in Greek clinical practice: Data from a contemporary, real-world multicenter cohort [coronary computed tomography angiography – Greece (COCOA-GR)]

Autori: Alexios S. Antonopoulos, Spyridon Simantiris, Georgios Benetos, Charalampos Papastamos, Nikolaos Axypolitos, Pete Tomlins, Aikaterini Pappa, Kalliopi Grigoriou, Ioannis Andrikou, Dimitrios Terentes-Printzios, Dimitrios Manos, Panagiotis Korkonikitas, Dimitrios Papandreou, Spyridoula Katsilouli, Olga Karapanagiotou, Ioannis Skoumas, Konstantinos Toutouzas, Thomas Vrachliotis, Dimitrios Tousoulis, K
Pubblicato in: Atherosclerosis, Numero 407, 2025, Pagina/e 119777, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2025.119777

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study

Autori: Larissa Fabritz, Christoph Al-Taie, Katrin Borof, Günter Breithardt, A John Camm, Harry J G M Crijns, Victor Roth Cardoso, Winnie Chua, Silke van Elferen, Lars Eckardt, Georgios Gkoutos, Andreas Goette, Eduard Guasch, Stéphane Hatem, Andreas Metzner, Lluís Mont, Vaishnavi Ameya Murukutla, Julius Obergassel, Andreas Rillig, Moritz F Sinner, Renate B Schnabel, Ulrich Schotten, Laura C Sommerfeld,
Pubblicato in: European Heart Journal, Numero 45, 2024, Pagina/e 5002-5019, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehae611

Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy

Autori: Dan Atar, Christophe Vandenbriele, Stefan Agewall, Bruna Gigante, Andreas Goette, Diana A Gorog, Pål A Holme, Konstantin A Krychtiuk, Bianca Rocca, Jolanta M Siller-Matula, Marco Valgimigli, Andrea Rubboli, Robert Klamroth
Pubblicato in: European Heart Journal - Cardiovascular Pharmacotherapy, Numero 11, 2025, Pagina/e 275-289, ISSN 2055-6837
Editore: Oxford University Press (OUP)
DOI: 10.1093/ehjcvp/pvaf006

Late diagnosis of Marfan syndrome is associated with unplanned aortic surgery and cardiovascular death

Autori: Jason Claus, Lauritz Schoof, Thomas S. Mir, Anna Lena Kammal, Gerhard Schön, Kerstin Kutsche, Christian-Alexander Behrendt, Klaus Kallenbach, Tilo Kölbel, Christian Kubisch, Till Joscha Demal, Johannes Petersen, Jens Brickwedel, Michael Hübler, Christian Detter, Paulus Kirchhof, Eike Sebastian Debus, Meike Rybczynski, Yskert von Kodolitsch
Pubblicato in: The Journal of Thoracic and Cardiovascular Surgery, Numero 169, 2025, Pagina/e 1201-1209.e33, ISSN 0022-5223
Editore: Mosby Inc.
DOI: 10.1016/j.jtcvs.2024.09.016

Chronic total occlusion of infarct-related artery: A bystander or a risk factor of electrical storm?

Autori: Tsuji Y, Dobrev D
Pubblicato in: Int J Cardiol, 2022, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1016/j.ijcha.2022.101051

From translation to integration: how to approach the complexity of atrial fibrillation mechanisms

Autori: Schotten U.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab168

Atrial fibrillation and stroke: are we looking in the right direction?

Autori: Hatem SN, Cohen A.
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab341

Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance

Autori: XiaoYan Qi, Feng Xiong, Jiening Xiao, Kalai Mangai Muthukumarasamy, Yasemin Altuntas, Yuan Zhong, Issam Abu-Taha, Florian Bruns, Marcel Tekook, Markus Kamler, Louis Villeneuve, Anna Nozza, Martin Sirois, Jason Karch, Philippe Pasdois, Donald M. Bers, Dobromir Dobrev, Stanley Nattel
Pubblicato in: 2025
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.29.635508

Mechanistic Insights into Sex Differences in Atrial Electrophysiology and Arrhythmia Vulnerability through Sex-specific Computational Models

Autori: Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi
Pubblicato in: 2025
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.08.18.670886

Automated Pipeline for Regional Epicardial Adipose Tissue Distribution Analysis in the Left Atrium

Autori: Èric Lluch, Eduardo Castañeda, Maximilian E. R. Weiss, Anamaria Vizitiu, Athira Jacob, Jitin Jami, Chloé Audigier, Felix Meister, Viorel Mihalef, Tiziano Passerini
Pubblicato in: Lecture Notes in Computer Science, Statistical Atlases and Computational Models of the Heart. Workshop, CMRxRecon and MBAS Challenge Papers., 2025, Pagina/e 323-333
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-031-87756-8_32

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