Plastics fate and effects in the human body

Livrables

Review of current regulations, and policy and market

This will identify any knowledge gaps that need to be addressed through project activities as well as understanding the current state of the art including products on the market and identifying key stakeholders

Report on selected MP/NP and basic PChem features

In the report it will be explained how the selection storage distribution and basic characterization of material is performed In addition some techniques for labeling and traceability of materials will be described

Overview of human exposure sources and levels of MP/NP

Report with a comprehensive overview of the human exposure levels of MPNP related to their different sources based on the recent literature and measured and modelled data from previous projects

Cluster brochure

The cluster brochure will be developed

Establishing a human health RA strategy for MP/NP

This will be implemented in the form of an integrated testing strategy (ITS) which specifies a tied, step-by-step procedure with the associated test systems (IATAs). Interim report by M24.

State of the art in microplastic risk assessement

The report will summarise the legal requirements for the regulation of plastic Possible gaps in the current legal frameworks as well as data needs will be identified and specified

Prototype of the prospective multi criteria decision support system (PMCDS)

The PMCSD will support end-users through an early decision-making process in an prospective approach integrating data on applications, performance needs, exposure and hazard. This prototype will allow the conduction of case studies.

Joint policy briefs 1
Risk assessment of MP/NP to act as pathogen vectors

Report with the results obtained through flow cytometry-based method and molecular tools.

Modelling of MP/NP for environmental fate, human exposure and toxicokinetics

The mathematical equations that compose the environmental fate, human exposure, and toxicokinectic prediction models as well as the parameters considered will be collected and explained in a report.

Web and social media presence

A project website will be produced that acts as a repository and shop front for all publishable project output This will connect with social media channels such as LinkedIn Twitter and YouTube Task 61

Prototype of a web-based decision support system

A web-based e-tool will be developed to estimate human and environmental health risks along the lifecycle of plastic materials and products. The prototype will include most of the features and presented for discussion to the partners.

Cluster web portal and visual identity

The cluster web portal and visual identity will be developed.

Publications

Digestión gastrointestinal y fermentación colónica de microplásticos biodegradables de ácido poliláctico (PLA) y su interacción con la microbiota intestinal

Auteurs: Jiménez Arroyo, Cristina; Tamargo García, Alba; Molinero, Natalia; Jiménez Reinosa, Julián; Alcolea-Rodríguez, Víctor; Portela, Raquel; Bañares, Miguel A.; Fernández Lozano, José Francisco; Moreno-Arribas, M. Victoria
Publié dans: instname:Consejo Superior de Investigaciones Científicas (CSIC), Numéro 1, 2023
Éditeur: DIGITAL CSIC

Useful Gut Model for Plastic Particles Assessing

Auteurs: Giulia, Antonello; Esposito, Marianna; Barbero, Francesco; Macaraig Mansilungan, Camille; Fenoglio, Ivana; Riganti, Chiara; Bergamaschi, Enrico
Publié dans: CUSP Meeting, 2022
Éditeur: CUSP
DOI: 10.5281/zenodo.7267318

Co-culture of human type I and type II pneumocyte cell lines as a model of alveolar epithelium

Auteurs: Boland, Sonja; Brookes, Oliver; Kuen, Rene Lai; Miremont, Dorian; Eon-Bertho; Mawas, Safaa; Baeza-Squiban, Amelle
Publié dans: STCM 2022, 2022
Éditeur: STCM 2022
DOI: 10.5281/zenodo.7142483

Microplásticos y microbiota. Impacto de la ingesta de diferentes tipos de microplásticos sobre la microbiota colónica humana

Auteurs: Tamargo García, Alba; Molinero, Natalia; Jiménez Arroyo, Cristina; Jiménez Reinosa, Julián; Alcolea-Rodriguez, Victor; Portela, Raquel; Bañares, Miguel A.; Fernández, Jose F.; Moreno-Arribas, M. Victoria
Publié dans: instname:, Numéro 1, 2022
Éditeur: CSIC

From principles to reality. FAIR implementation in the nanosafety community

Auteurs: Dumit, Verónica I.; Ammar, Ammar; Bakker, Martine; Bañares, Miguel A.; Bossa, Cecilia; Costa, Anna; Cowie, Hilary; Drobne, Damjana; Exner, Thomas E.; Farcal, Lucian; Friedrichs, Steffi; Furxhi, Irini; Grafström, Roland; Haase, Andrea; Himly, Martin; Jeliazkova, Nina; Lynch, Iseult; Maier, Dieter; Noorlander, Cornelle W.; Shin, Hyun Kil; Soler-Illia, Galo J.A.A.; Suarez-Merino, Blanca; Willighag
Publié dans: Nano Today, Numéro 3, 2023, ISSN 1748-0132
Éditeur: Elsevier BV
DOI: 10.1016/j.nantod.2023.101923

Nano- and microplastics commonly cause adverse impacts on plants at environmentally relevant levels: A systematic review

Auteurs: Zantis, L.J.; Borchi, C.; Vijver, M.G.; Peijnenburg, W.J.G.M.; Di Lonardo, S.; Bosker, T.
Publié dans: Science of the total environment 867 (2023). doi:10.1016/j.scitotenv.2022.161211, Numéro 3, 2023, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2022.161211

The analytical quest for sub-micron plastics in biological matrices

Auteurs: Fazel Abdolahpur Monikh; Fazel Abdolahpur Monikh; Martina G. Vijver; Denise M. Mitrano; Heather A. Leslie; Zhiling Guo; Peng Zhang; Iseult Lynch; Eugenia Valsami-Jones; Willie J.G.M. Peijnenburg
Publié dans: Nano Today, 41, Numéro 3, 2021, ISSN 1748-0132
Éditeur: Elsevier BV
DOI: 10.1016/j.nantod.2021.101296

perspectives on toxicokinetics of nanoscale plastic debris in organisms

Auteurs: Fazel Abdolahpur Monikh; Martina G. Vijver; Raine Kortet; Iseult Lynch; Willie J. G. M. Peijnenburg
Publié dans: Environmental Science: Nano, Numéro 3, 2022, ISSN 2051-8161
Éditeur: RSC
DOI: 10.1039/d1en00425e

Submicron Plastic Adsorption by Peat, Accumulation in Sphagnum Mosses and Influence on Bacterial Communities in Peatland Ecosystems

Auteurs: Mandar Bandekar; Fazel Abdolahpur Monikh; Jukka Kekäläinen; Teemu Tahvanainen; Raine Kortet; Peng Zhang; Zhiling Guo; Jarkko Akkanen; Jari T. T. Leskinen; Miguel A. Gomez-Gonzalez; Gopala Krishna Darbha; Hans-Peter Grossart; Eugenia Valsami-Jones; Jussi V. K. Kukkonen
Publié dans: Environmental Science and Technology, Numéro 3, 2022, Page(s) 15661–15671, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.2c04892

From properties to toxicity: Comparing microplastics to other airborne microparticles

Auteurs: Simon Wieland, Aylin Balmes, Julian Bender, Jonas Kitzinger, Felix Meyer, Anja FRM Ramsperger, Franz Roeder, Caroline Tengelmann, Benedikt H. Wimmer, Christian Laforsch, Holger Kress
Publié dans: Journal of Hazardous Materials, Numéro Volume 428,, 2022, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.128151

Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review

Auteurs: Panizzolo, Marco; Martins, Vitor Hugo; Ghelli, Federica; Squillacioti, Giulia; Bellisario, Valeria; Garzaro, Giacomo; Bosio, Davide; Colombi, Nicoletta; Bono, Roberto; Bergamaschi, Enrico
Publié dans: Ecotoxicology and Environmental Safety Volume 267, 15 November 2023, 115645, Numéro Volume 267, 15 November 2023, 115645, 2023, ISSN 1090-2414
Éditeur: Elsevier
DOI: 10.1016/j.ecoenv.2023.115645

The gut microbiota, a key to understanding the health implications of micro(nano)plastics and their biodegradation

Auteurs: Cristina Jiménez‐Arroyo; Alba Tamargo; Natalia Molinero; M. Victoria Moreno‐Arribas
Publié dans: Microbial Biotechnology, Vol 16, Iss 1, Pp 34-53 (2023), Numéro 2, 2022, ISSN 1751-7915
Éditeur: Microbial Biotechnology
DOI: 10.1111/1751-7915.14182

Estrogenic activity of plastic nanoparticle mixtures under <i>in vitro</i> settings

Auteurs: Lucija Božičević; Korinna Altmann; Jana Hildebrandt; Xenia Knigge; Valerije Vrček; Nikolina Peranić; Nikolina Kalčec; Ivana Vinković Vrček
Publié dans: Environmental Science: Nano, Numéro 2, 2024, Page(s) Numéro 5, 2024, ISSN 2051-8161
Éditeur: RSC
DOI: 10.1039/d3en00883e

Exposure protocol for ecotoxicity testing of microplastics and nanoplastics

Auteurs: Fazel Abdolahpur Monikh; Anders Baun; Nanna B. Hartmann; Raine Kortet; Jarkko Akkanen; Jae-Seong Lee; Huahong Shi; Elma Lahive; Emilia Uurasjärvi; Nathalie Tufenkji; Korinna Altmann; Yosri Wiesner; Hans-Peter Grossart; Willie Peijnenburg; Jussi V. K. Kukkonen
Publié dans: NATURE PROTOCOLS, Numéro 3, 2023, Page(s) 3534–3564, ISSN 1750-2799
Éditeur: NATURE.COM
DOI: 10.1038/s41596-023-00886-9

Sub-micro- and nano-sized polyethylene terephthalate deconstruction with engineered protein nanopores

Auteurs: Robles-Martín, Ana; Amigot-Sánchez, Rafael; Fernandez-Lopez, Laura; Gonzalez-Alfonso, Jose L; Roda, Sergi; Alcolea-Rodriguez, Víctor; Heras-Márquez, Diego; Almendral, David; Coscolín, Cristina; Plou, Francisco J; Portela, Raquel; Bañares, Miguel A; Martínez-del-Pozo, Álvaro; García-Linares, Sara; Ferrer, Manuel; Guallar, Víctor
Publié dans: Nature Catalysis, Numéro 3, 2023, Page(s) 1174–1185, ISSN 2520-1158
Éditeur: Nature Catalysis
DOI: 10.1038/s41929-023-01048-6

Nano- and microplastics: a comprehensive review on their exposure routes, translocation, and fate in humans

Auteurs: Ramsperger, Anja FRM; Bergamaschi, Enrico; Panizzolo, Marco; Fenoglio, Ivana; Barbero, Francesco; Peters, Ruud; Undas, Anna; Purker, Sebastian; Giese, Bernd; Lalyer, Carina R; Tamargo, Alba; Moreno-Arribas, M Victoria; Grossart, Hans-Peter; Kühnel, Dana; Dietrich, Jana; Paulsen, Friedrich; Afanou, Anani K; Zienolddiny-Narui, Shan; Eriksen Hammer, Stine; Kringlen Ervik, Torunn; Graff, Pål; Brinch
Publié dans: NanoImpact, Numéro 2, 2022, ISSN 2452-0748
Éditeur: Elsevier B.V.
DOI: 10.1016/j.impact.2022.100441

Quantifying the trophic transfer of sub-micron plastics in an assembled food chain

Auteurs: Monikh, Fazel Abdolahpur; Holm, Sille; Kortet, Raine; Bandekar, Mandar; Kekäläinen, Jukka; Koistinen, Arto; Leskinen, Jari TT; Akkanen, Jarkko; Huuskonen, Hannu; Valtonen, Anu; Dupuis, Lan; Peijnenburg, Willie; Lynch, Iseult; Valsami-Jones, Eugenia; Kukkonen, Jussi V.K.
Publié dans: Nano Today, Numéro 3, 2022, ISSN 1878-044X
Éditeur: Elsevier
DOI: 10.1016/j.nantod.2022.101611

Simulated Gastrointestinal Digestion of Polylactic Acid (Pla) Biodegradable Microplastics and Their Interaction with Gut Microbiota

Auteurs: Jiménez Arroyo, Cristina; Tamargo, Alba; Molinero, Natalia; Reinosa, J. J.; Alcolea-Rodríguez, Víctor; Portela, Raquel; Bañares, Miguel A.; Fernández Lozano, José Francisco; Moreno-Arribas, M. Victoria
Publié dans: Crossref, Numéro 1, 2023, Page(s) 166003, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.2139/ssrn.4463181

Role of the Protein Corona in the Colloidal Behavior of Microplastics

Auteurs: Marion Schvartz; Florent Saudrais; Stéphanie Devineau; Stéphane Chédin; Frédéric Jamme; Jocelyne Leroy; Karol Rakotozandriny; Olivier Taché; Guillaume Brotons; Serge Pin; Yves Boulard; Jean-Philippe Renault
Publié dans: "Langmuir, 2023, 39 (12), pp.4291-4303. ⟨10.1021/acs.langmuir.2c03237⟩", Numéro 3, 2023, Page(s) 4291–4303, ISSN 1520-5827
Éditeur: American Chemical Society
DOI: 10.1021/acs.langmuir.2c03237

Defining Quality Criteria for Nanoplastic Hazard Evaluation: The Case of Polystyrene Nanoplastics and Aquatic Invertebrate Daphnia spp.

Auteurs: Jemec Kokalj, Anita; Heinlaan, Margit; Novak, Sara; Drobne, Damjana; Kühnel, Dana
Publié dans: Volume 13, Numéro 3, 2023, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano13030536

Nominally identical microplastic models differ greatly in their particle-cell interactions

Auteurs: Simon Wieland; Anja F. R. M. Ramsperger; Wolfgang Gross; Moritz Lehmann; Thomas Witzmann; Anja Caspari; Martin Obst; Stephan Gekle; Günter K. Auernhammer; Andreas Fery; Christian Laforsch; Holger Kress
Publié dans: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024), Numéro 1, 2024, Page(s) 15:922, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-45281-4

Evaluation of Nanoparticle Tracking Analysis (NTA) for the Measurement of Nanoplastics in Drinking Water

Auteurs: Ruud J.B. Peters; Emma Relou; Eelco L.E. Sijtsma; Anna K. Undas
Publié dans: Research Square, Numéro 1, 2024, ISSN 2693-5015
Éditeur: Research Square
DOI: 10.21203/rs.3.rs-1809144/v1

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