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DEVELOPMENT OF METABOLICALLY COMPETENT IN VITRO MODELS FOR FOOD SAFETY EVALUATION

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The overall objective is to develop in vitro assays using immortalised human cell lines for increased food safety. Specifically this will be achieved by fulfilling the following objectives:

- developing immortalised cell lines from human target organs and characterising their metabolic competence in comparison with normal tissues - correcting metabolic deficiencies in the developed cell lines by genetic manipulation
- establishing assays for cytoxicity, genotoxicity and malignant transformation using the developed cell lines.

Completion of this project will allow more rapid prediction of target organ-specific harmful or beneficial effects of food, including contaminants and additives. It will contribute to reduction, refinement and eventual replacement of animal tests.

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Koordinator

Unilever UK Central Resources Ltd
EU-Beitrag
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Adresse
Colworth House
MK44 1LQ Sharnbrook
Vereinigtes Königreich

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Beteiligte (14)