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FISH PROTECTION IN AQUACULTURE : IMPROVEMENT OF VACCINE EFFICACY BY STUDYING STIMULATION OF THE FISH IMMUNE RESPONSE

Objectif



This project will focus on the stimulation of a protective immune response in fish, the understanding of the mechanisms involved and further the ability to design optimal vaccines allowing a high protective immunity. Two fish species will be studied: salmonids (rainbow trout, Oncorhyncus mykiss, and salmon, Salmo salar) and cypronids (carp, Cyprinus carpio L.), and immune stimulation will be performed with two viral pathogens: the SVC virus (Spring Viremia of Carp) and the VHS virus (Viral Haemorrhagic Septicemia) infecting salmonids. We will use in particular a well characterized antigen from these viruses, the G protein which will be produced in microorganisms and purified.

The stimulation of a protective immune response is divided into various essential steps that requires multi-disciplinary analysis: antibody production, antigen presentation, B-cells stimulation and T-cells functions, cytotoxicity, and cytokine-mediated response. These studies will lead to the determination of the best immunisation and design of optimal immunogens for fish vaccination.

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

SOCIETE EUROPEENNE DE BIOTECHNOLOGIE S.A.
Contribution de l’UE
Aucune donnée
Adresse
RUE BOIS SAINT JEAN 14
4102 SERAING
Belgique

Voir sur la carte

Coût total
Aucune donnée

Participants (6)