Structure and function of glutamate receptors

Informazioni relative al progetto

ID dell’accordo di sovvenzione: BIO2930243

Progetto chiuso

Data di avvio 1 Settembre 1993

Data di completamento 31 Agosto 1996

Finanziato da

• Specific research and technological development programme (EEC) in the field of biotechnology, 1990-1994

Costo totale

Nessun dato

Contributo UE

€ 1 500 000,00

Coordinato da

Centre National de la Recherche Scientifique (CNRS)
France

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Risultati sfruttabili

Glutamate receptors

The amino acid glutamate is the neurotransmitter responsible for most of the excitatory synaptic transmission in the central nervous system. It plays a central role in many important physiological processes including learning and memory. The diverse effects of glutamate are mediated by a number of membrane bound receptors. Research was carried out in order to obtain the 3-dimensional structure of the glutamate receptor. A method was developed to determine the actual subunit composition of native AMPA ionotropic glutamate receptors. This was applied to visual cortex neurons. The method has now been adapted to N-methyl-D-aspartate (NMDA) and kainate receptors. With this technique, the subunit composition of the kainate receptor in the hippocampus has been identified. Also, the ionic properties of the NMDA channels have been characterized in more detail. New ligands have been prepared for the AMPA receptors and a new splice variant of the metabotropic receptor mGluR5 has been characterized.