Objective
It is our aim to contribute to the understanding of drug resistance of HIV-RT by comparing structure and function of wild type and drug-resistant HIV-RT using physical and chemical methods.
Drug resistance is an inherent problem in HIV monotherapy. One possible way to overcome or to reduce this problem might be the application of a combination of drugs. The choice of suitable drug combination is a problem which remains to be solved. In order to improve the basis for a sound formulation of a combination therapy, information about the function of resistant mutants is required. This project focuses on the in vitro study of structure and function of HIV-RT mutants resistant against nucleosidic inhibitors. In order to achieve a better understanding of the molecular mechanism of drug resistance, analysis of wild type HIV-RT is included in the study.
Special emphasis will be put on the analysis of those nucleoside inhibitor mutants exhibiting a better replication function. The interest in these mutants is based on the conjecture that they might be able to repress the other HIV strains in a host because they have a selection advantage. If this view is correct subsequent treatment with a second inhibitor using knockout conditions might be more successful. The project is a collaborative effort of four European groups and a Canadian group as subcontractor. It will be applied a combination of physical, biochemical and enzymatic methods, such as x-ray crystallography (Strasbourg), NMR-techniques(Zurich), neutron solution scattering(Munich), chemical and radioactive (gamma-ray) probing and enzymatic analysis(Munich, Rome, Strasbourg to HIV-RT, wild type and mutants. The final goal of the project is to provide the molecular basis for a more effective combination therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
82152 MARTINSRIED
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.