Obiettivo The group succeeded in modification of the device surfaces (including the inner surface of tubes) in order to obtain hydrophilic surfaces, and thereby to decrease the bacterial adhesion, at least in vitro. This was documented to be true for most types of plastics which are used for Medical Devices today. However, no statistical significant effect could be demonstrated in an in vivo model including plasma modified and unmodified samples of PE.As the bacterial adhesion differs very much depending on the kind of plastic material, the effect of plasma modification needs to be investigated in vivo of each relevant material, before any generalisation can take place.The plasma modification process did not alter the biocompatibility of the PE-samples in the above in vivo experiment. This also needs to be examined in each cases. By use of plasma processes the team succeeded in improving the permeability and create a barrier to relevant test gasses in order to be able to use alternative materials to soft PVC in production of medical bags. We managed to develop compounds with kinking and mechanical properties better than the commercial PVC-alternatives tested, but not as good as PVC. The possibilities of using plasma processes as a simultaneous sterilization method were documented to be very promising. It was demonstrated that active species in different plasmas were able to destroy test bacteria.The increasing application of medical devices has caused a dramatic increase in the number of device-related infections. At the same time the part of the European Medical Device Industry dealing with plastics is faced by environmental demands for finding alternatives to PVC as well as toxicological demands for finding an alternative to the ethylene-oxide sterilization method.The objectives of this research are therefore by strategic efforts to solve these problems including technical development within plasmapolymerization techniques.The research will include the development and optimization of medical plastics by compounding techniques as well as development and improvement of biological tests for evaluation of the ability of the developed materials to resist infections. Campo scientifico natural sciencesbiological sciencesmicrobiologybacteriology Programma(i) FP3-BRITE/EURAM 2 - Specific programme (EEC) of research and technological development in the field of industrial and materials technologies, 1990-1994 Argomento(i) 1.4.5 - Biomaterials Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore Danish Technological Institute (DTI) Contributo UE Nessun dato Indirizzo Gregersensvej DK-2630 Taastrup Danimarca Mostra sulla mappa Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BAXTER R&D EUROPE Belgio Contributo UE Nessun dato Indirizzo 7 RUE DU PROGRES 1400 NIVELLES Mostra sulla mappa Costo totale Nessun dato Plasma Technology Ltd Regno Unito Contributo UE Nessun dato Indirizzo North End Yatton BS19 4AP Bristol Mostra sulla mappa Costo totale Nessun dato STATENS SERUMINSTITUT Danimarca Contributo UE Nessun dato Indirizzo ARTILLERIVEJ 5 2300 COPENHAGEN S Mostra sulla mappa Costo totale Nessun dato TOTAX PLASTIC A/S Danimarca Contributo UE Nessun dato Indirizzo STAKTOFTEN 22 2950 VEDBAEK Mostra sulla mappa Costo totale Nessun dato