Acute promyelocytic leukaemia: pathogenesis and molecular basis of retinoic acid differentiation treatment

Informazioni relative al progetto

ID dell’accordo di sovvenzione: CIPD940253

Progetto chiuso

Data di avvio 1 Giugno 1995

Data di completamento 31 Maggio 1997

Finanziato da

• Scientific and technological cooperation between the European Community and European non-member countries, 1992-

Costo totale

Nessun dato

Contributo UE

Nessun dato

Coordinato da

Università degli Studi di Perugia
Italy

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Risultati sfruttabili

Cytochemical and cytophotometrical characteristics of DNP, RNP and basic proteins in the peripheral blood leucocytes

Cytochemical and quantitative/cytophotometrical characteristics of DNP, RNP and basic proteins in the peripheral blood leucocytes (PBCs)- in connection with data of participation of lymphocytes (including tumour-infiltrating lymphocytes - TIL) and granulocytes in the response to tumours during the course of neoplastic process, have been studied in the cases of early and advanced neoplastic disease, as well as in pre-cancerous states. The results shows that some quantitative changes in the PBCs' and especially TIL' cytoplasmic RNP-, DNP-content and distribution (in the histograms of individual cell nuclei), and basic proteins' content, have a great information capability for the purposes of qualitative and automatic selection of the normal and abnormal PBCs of cancer patients. Possible application of this method for early diagnosis of tumours and pre-cancerous states has been proposed