Environmental Monitoring by Fluorescence Induction and Detection

Informazioni relative al progetto

ID dell’accordo di sovvenzione: ENV4970480

Progetto chiuso

Data di avvio 1 Novembre 1997

Data di completamento 30 Aprile 2001

Finanziato da

• Specific programme of research and technological development in the field of environment and climate, 1994-1998

Costo totale

Nessun dato

Contributo UE

Nessun dato

Coordinato da

University of Manchester Institute of Science and Technology (UMIST)
United Kingdom

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Risultati sfruttabili

Environmental monitoring by fluorescence induction and detection

A novel biosensor has been developed which can detect deoxyribonucleic acid (DNA) damaging chemicals. Such genotoxic chemicals can cause cancer in humans. The biosensor presents advantages over the existing Ames test (which merely measures survival rates in bacteria). It is amenable to continuous, high throughput screening. The organism at the heart of the biosensor, yeast, possesses similar DNA-damage response systems to human cells. It is a generic reporter: it can be adapted to detect other types of damage, such as oxidative stress, with high specificity. The output signal, fluorescence, is readily measurable in living cells and is reagent free. The biosensor can be employed in water supply monitoring (genotoxicity is a legislative issue for polluters and water supply companies) and for compound screening (no dangerous drugs or additives are involved).