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Contenuto archiviato il 2024-04-30

Brain-specific gene expression

Obiettivo



A large number of cell types are found in the vertebrate brain but there is little understanding of how this diversity is controlled at the genetic level. To identify regulatory factors that govern neuronal phenotype, we wish to utilise as a starting point a gene whose expression is characteristic of a particular neuronal cell type. The gene encoding the a6 subunit of GABAA receptors serves as a unique marker for differentiated cerebellar granule cells. No expression is found in other brain regions, or in peripheral tissues. My research plan centres around defining the DNA regulatory regions (enhancers/silencers) of the a6 subunit gene using transgenic mice, and mapping DNase I hypersensitive sites. The transcription factors that act on these sites could turn out to be of general importance, and may direct cellular differentiation in a variety of neuronal tissues.

Campo scientifico (EuroSciVoc)

Programma(i)

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Invito a presentare proposte

Dati non disponibili

Meccanismo di finanziamento

RGI - Research grants (individual fellowships)

Coordinatore

MRC Laboratory of Molecular Biology
Contributo UE
Nessun dato
Indirizzo
Hills Road
CB2 2QH Cambridge
Regno Unito
Costo totale
Nessun dato

Partecipanti (1)