Obiettivo The aim of this project is to elucidate some of the molecular mechanisms that underlie the early definition of dorso-ventral axis in vertebrates, using Xenopus as a model system. The Nieuwkoop Center (NC), located in the dorsal-vegetal cells of blastulae, constitutes the first organizing center during embryogenesis and it is defined by the relocation of maternal of dorsal determinants. It acts by inducing Spemann's organizer in the overlying mesodermal cells. In spite of its central role in dorso-ventral axis formation, the mechanisms involved in the definition of the NC are unclear. This project proposes to tackle this issue by studying the spatial regulation of Siamois, a homebox gene expressed in the NC. After cloning the genomic sequences of Siamois, we will define the cis regulatory elements present that are important for its spatial expression. Once determined, it will be possible to purify the maternal determinants that bind these sequences. Campo scientifico natural sciencesbiological sciencesdevelopmental biology Programma(i) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Argomento(i) 0302 - Post-doctoral research training grants TL06 - Developmental Biology Invito a presentare proposte Data not available Meccanismo di finanziamento RGI - Research grants (individual fellowships) Coordinatore Centre National de la Recherche Scientifique Contributo UE Nessun dato Indirizzo Campus de Luminy 13288 Marseille Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Not available Spagna Contributo UE Nessun dato Indirizzo Mostra sulla mappa Costo totale Nessun dato