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Contenido archivado el 2024-05-14

Mammalian mrna poly(a) tails, formation removal and function

Objetivo



We propose to establish a network of collaborating research teams having the mRNA poly (A) tail as a common scientific denominator. All mamalian mRNAs have at 3' ends a 200 residues long poly (A) tail. The poly (A) tail is added post-transcriptionally (nuclear
polyadenylation) and this reaction is used by all type of cells to regulate gene expression. In some cells the lengh of the poly (A) tail is metabolised, either by removal or by readdition. Modulating the length of the poly (A) tail regulates translational capacity of an mRNA. Research within this network will increase knowledge in: 1) biochemical details of nuclear polyadenylation.
2) regulation of gene expression through poly (A) site selection 3) functional importance of poly (A) tail metabolism.
We propose to establish an advanced "school" for training of young post-doctoral fellows. After completion of the three year programme participating fellows should be able to establish independent research programs in their home countries. The young scientists will receive training in:
1) theoretical, experimental and methodological scientific
approaches.
2) organisation and execution of advanced practical and theoretical courses/workshops.
3) interaction and communication with other scientists.

Ámbito científico (EuroSciVoc)

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Programa(s)

Tema(s)

Convocatoria de propuestas

Datos no disponibles

Régimen de financiación

NET - Research network contracts

Coordinador

Uppsala University
Aportación de la UE
Sin datos
Dirección
3,Husargatan
751 23 Uppsala
Suecia
Coste total
Sin datos

Participantes (7)