Objective
* Development of candidate vaccines against parasitic filarial infections, in particular Onchocerca volvulus.
* To identify, isolate and express antigens that are specific to the larval stages of these parasites.
* To analyse of the immune responses of humans exposed to O.volvulus and animals infected with Acanthoche lonema viteae to these antigens.
* To assess the protective capacity of these antigens in a rodent filarial model system.
Expected Outcome
* The identification of novel candidate vaccine antigens for onchocerciasis.
* The identification of the type of immune responses that are protectiveagainst filarial infections in humans and animal models.
* Production of quantities of L3 and L4 larval stages of the parasites Onchocerca volvulus and Acanthocheilonema viteae.
* Identification and characterisation of antigens that are specific to the larval stages of the parasite by protein analysis and differential display PCR.
* Cloning and Expression of stage specific antigens from cDNA libraries of each larval stage.
* Characterisation of the cellular and humoral responses to the larval antigens of putatively immune humans exposed to onchocerciasis transmisson.
* Evaluation of the protective capacity of the recombinant larval antigens in a rodent filarial model system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
M5 4WT Salford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.