Objetivo * Development of candidate vaccines against parasitic filarial infections, in particular Onchocerca volvulus.* To identify, isolate and express antigens that are specific to the larval stages of these parasites.* To analyse of the immune responses of humans exposed to O.volvulus and animals infected with Acanthoche lonema viteae to these antigens.* To assess the protective capacity of these antigens in a rodent filarial model system.Expected Outcome* The identification of novel candidate vaccine antigens for onchocerciasis.* The identification of the type of immune responses that are protectiveagainst filarial infections in humans and animal models.* Production of quantities of L3 and L4 larval stages of the parasites Onchocerca volvulus and Acanthocheilonema viteae.* Identification and characterisation of antigens that are specific to the larval stages of the parasite by protein analysis and differential display PCR.* Cloning and Expression of stage specific antigens from cDNA libraries of each larval stage.* Characterisation of the cellular and humoral responses to the larval antigens of putatively immune humans exposed to onchocerciasis transmisson.* Evaluation of the protective capacity of the recombinant larval antigens in a rodent filarial model system. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Tema(s) 03010302 - Research on the tools for prevention and the fight against the predominant diseases Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador University of Salford Aportación de la UE Sin datos Dirección The Crescent M5 4WT Salford Reino Unido Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Hospital Vozandes Ecuador Aportación de la UE Sin datos Dirección 263,Villalengua 263 10 Quito Ver en el mapa Coste total Sin datos Humboldt-Universität zu Berlin Alemania Aportación de la UE Sin datos Dirección 56,Luisenstrasse 56 10117 Berlin Ver en el mapa Coste total Sin datos Institut de Recherches Medicales et d'Etude des Plantes Medicinales Camerún Aportación de la UE Sin datos Dirección 40 Kumba Ver en el mapa Coste total Sin datos UNIVERSITY OF BUEA Camerún Aportación de la UE Sin datos Dirección 20 BUEA Ver en el mapa Coste total Sin datos