Objective
In the last decade an increasing interest of researchers from both fundamental and applied domains has been focused on studying protein stability and enzyme regulation under extreme conditions. Together with the attempts at better understanding the proteins from extremophiles (thermophiles, halophiles, barophiles etc.), extreme conditions are used for the enzymes from mesophilic sources. The goal of this project is two-fold: determine structural principles lying at the basis of function and stability of proteins and more complex systems; and adapt the enzymes to extreme conditions of high temperatures, high pressures, and organic solvents.
The practical objective of such adaptation is obvious: a vast amount of processes in the food and pharmaceutical industries, fine organic synthesis, analysis, and other biotechnological areas demand short-term or prolonged exposure of proteins to what is called extreme conditions. In this case, care should be taken in order to prevent protein deterioration and success can be achieved based only on a knowledge of protein behaviour under extreme conditions.
Special interest will be paid to denaturation of enzymes by temperature, high pressures, and organic solvents with the aim of eluciding some common features responsible for protein stability. The possibilities of regulating the enzyme activity and specificity under extreme conditions will be studied.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
34033 Montpellier
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.