Objectif In the last decade an increasing interest of researchers from both fundamental and applied domains has been focused on studying protein stability and enzyme regulation under extreme conditions. Together with the attempts at better understanding the proteins from extremophiles (thermophiles, halophiles, barophiles etc.), extreme conditions are used for the enzymes from mesophilic sources. The goal of this project is two-fold: determine structural principles lying at the basis of function and stability of proteins and more complex systems; and adapt the enzymes to extreme conditions of high temperatures, high pressures, and organic solvents. The practical objective of such adaptation is obvious: a vast amount of processes in the food and pharmaceutical industries, fine organic synthesis, analysis, and other biotechnological areas demand short-term or prolonged exposure of proteins to what is called extreme conditions. In this case, care should be taken in order to prevent protein deterioration and success can be achieved based only on a knowledge of protein behaviour under extreme conditions. Special interest will be paid to denaturation of enzymes by temperature, high pressures, and organic solvents with the aim of eluciding some common features responsible for protein stability. The possibilities of regulating the enzyme activity and specificity under extreme conditions will be studied. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 42 - Physical Chemical Biology Appel à propositions Data not available Régime de financement Data not available Coordinateur Institut National de la Santé et de la Recherche Médicale Contribution de l’UE Aucune donnée Adresse Route de Mende 34033 Montpellier France Voir sur la carte Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Katholieke Universiteit Leuven Belgique Contribution de l’UE Aucune donnée Adresse 3001 Heverlee - Leuven Voir sur la carte Coût total Aucune donnée Moscow State University M.V. Lomonosov Russie Contribution de l’UE Aucune donnée Adresse 119899 Moscow Voir sur la carte Coût total Aucune donnée National Academy of Sciences of Ukraine Ukraine Contribution de l’UE Aucune donnée Adresse 270080 Odessa Voir sur la carte Coût total Aucune donnée Technische Universiteit Delft Pays-Bas Contribution de l’UE Aucune donnée Adresse 2628 BC Delft Voir sur la carte Coût total Aucune donnée