Objetivo In the last decade an increasing interest of researchers from both fundamental and applied domains has been focused on studying protein stability and enzyme regulation under extreme conditions. Together with the attempts at better understanding the proteins from extremophiles (thermophiles, halophiles, barophiles etc.), extreme conditions are used for the enzymes from mesophilic sources. The goal of this project is two-fold: determine structural principles lying at the basis of function and stability of proteins and more complex systems; and adapt the enzymes to extreme conditions of high temperatures, high pressures, and organic solvents. The practical objective of such adaptation is obvious: a vast amount of processes in the food and pharmaceutical industries, fine organic synthesis, analysis, and other biotechnological areas demand short-term or prolonged exposure of proteins to what is called extreme conditions. In this case, care should be taken in order to prevent protein deterioration and success can be achieved based only on a knowledge of protein behaviour under extreme conditions. Special interest will be paid to denaturation of enzymes by temperature, high pressures, and organic solvents with the aim of eluciding some common features responsible for protein stability. The possibilities of regulating the enzyme activity and specificity under extreme conditions will be studied. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) 42 - Physical Chemical Biology Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador Institut National de la Santé et de la Recherche Médicale Aportación de la UE Sin datos Dirección Route de Mende 34033 Montpellier Francia Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Katholieke Universiteit Leuven Bélgica Aportación de la UE Sin datos Dirección 3001 Heverlee - Leuven Ver en el mapa Coste total Sin datos Moscow State University M.V. Lomonosov Rusia Aportación de la UE Sin datos Dirección 119899 Moscow Ver en el mapa Coste total Sin datos National Academy of Sciences of Ukraine Ucrania Aportación de la UE Sin datos Dirección 270080 Odessa Ver en el mapa Coste total Sin datos Technische Universiteit Delft Países Bajos Aportación de la UE Sin datos Dirección 2628 BC Delft Ver en el mapa Coste total Sin datos
