Extreme conditions for studying protein stability and regulation

Informazioni relative al progetto

ID dell’accordo di sovvenzione: INTAS-93-0038

Progetto chiuso

Data di avvio 1 Settembre 1994

Data di completamento 31 Dicembre 1995

Finanziato da

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Costo totale

Nessun dato

Contributo UE

€ 85 000,00

Coordinato da

Institut National de la Santé et de la Recherche Médicale
France

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Risultati sfruttabili

Extreme conditions for studying protein stability and regulation

In the last decade an increasing interest of researchers from both fundamental and applied domains has been focused on studying protein stability and enzyme regulation under extreme conditions. Together with the attempts at better understanding the proteins from extremophiles (thermophiles, halophiles, barophiles etc.), extreme conditions are used for the enzymes from mesophilic sources. The goal of this project was two-fold: determine structural principles lying at the basis of function and stability of proteins and more complex systems; and adapt the enzymes to extreme conditions of high temperatures, high pressures, and organic solvents. This project includes five major research topics and co-ordination activity: - Baroenzymology in reversed micelles, - Electrophorensis of proteins in reversed micelles, - Pressure effects on protein stability, - Additivity in effects of extreme conditions on proteins, - Enzymes in cyro- and barogels.