Obiettivo
A novel method based on EM-SVD apply to protein comparison will be developed both for global and local similarities. A method for prediction of local antigen sites in primary structure as well as their comparison will be developed. The methods, that combine the stochastic approach of Expectation Maximization with the use of spectral graph theory for the Singular Value Decomposition, are expected to outperform most popular matching algorithms for proteins. This belief is supported by the fact that the EM-SVD approach has been very successful in image matching. The application of the methods above to real proteins as well as in vitro verification will be fulfilled. The databases with the results of comparison as well as the developed software will be available at the web site.
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E07122 Palma de Mallorca
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