Objectif
This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for the first time in Europe, adequate clinical resources and multidisciplinary critical mass. The work includes:
1) a multicentre randomised control trial of surgery for orofacial clefting (OFC);
2) a multicentre population based case-parental triad study of the role of specific genes, gene-environment interaction and gene-gene interaction in the aetiology of OFC;
3) a chromosomal approach to the identification of candidate genes for OFC;
4) development of sensitive molecular diagnostic assay for mutations underlying monogenic CFA; and
5) an informatics resource to underpin the other work and provide a dynamic resource to disseminate findings, assist CFA researchers, and promote good practice in clinical services. The project will be integrated with, and provide leadership for, a proposed global effort in the treatment and prevention of CFA.
Régime de financement
CSC - Cost-sharing contractsCoordinateur
M15 6FH Manchester
United Kingdom
Participants (18)
20142 Milano
1026 Budapest
81108 Bratislava
413 45 Goeteborg
4002 Plovdiv
13419 Tallinn
489031 Barakaldo-vizcaya
2900 Hellerup
6500 HB Nijmegen
0027 Oslo
4 Dublin
44100 Ferrara
1000 Ljubljana
AB25 2ZD Aberdeen
1017 Koebenhavn K/copenhaegen
DD1 4HR Dundee
00014 Helsinki
EH1 1HN Edinburgh