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The prevention of osteoporosis by nutritional phytoestrogens

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Is flavones, a subgroup of phytoestrogens mainly contained in soy and soy products, are widely held to have beneficial properties, but the evidence to date is only anecdotal. This proposal addresses the potential role of natural phytoestrogens in osteoporosis prevention among postmenopausal women living in Europe. A one-year large-scale, rnulticentre, randomised, controlled, intervention trial will be conducted in three European countries using specially-designed isoflavone-enriched foods, combined with rigorous assessments of the changes in bone metabolism. Acceptability of these foods among the target population (women 45 years of age and older) and expectations created by different nutritional claims will be addressed by conducting a survey in five EC state members.

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