Obiettivo
There is an urgent need for the discovery of novel antibacterial compounds to combat deadly emulate-drug resistant strains. Our targets are the proteins of initiation of DNA replication (IDR).Since they differ substantially in bacteria and eucalypts the bacterial IDR proteins constitute unattractive and unexplored family of targets for development of new antibiotics which is the essence of our proposal. The novelty of this approach lies in the development of assays to highlight the inhibition of IDR proteins and in the identification and/or design of compounds, which target IDRproteins. Our objective is to engineer bacterial strains for in vivo screening and in vitro biochemical detection methods for the identification of novel inhibitors of DNA replication initiation. High-throughput screening (HTS) and detailed structure-activity knowledge of the IDR protein inhibitors will bemused for synthetic modifications to enhance the specificity of targeting.
Campo scientifico
Invito a presentare proposte
Data not availableMeccanismo di finanziamento
CSC - Cost-sharing contractsCoordinatore
28049 MADRID
Spagna