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Aquaporin blockers for novel skin care products and diuretics

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Disturbances of body water balance severely affect the quality of life and can lead to life-threatening conditions. Aqua Orin (AQP) water channels play central roles in human water balance and are novel targets for pharmacological intervention. To screen for blockers (aqua plugs) of Asps, mammalian and yeast cell systems will be established. Inhibitors of aqua Orin function will be identified in compound libraries and rationally designed. The activity, specificity and toxicity profile of these aqua plugs will be determined in optimised cell- and integrated, systems. The atomic structures of Asps and AQP-aqua plug complexes will be elucidated and used to design optimised aqua Orin inhibitors. Studies will be performed to further determine the role of Asps in organ water balance in health and disease to identify additional conditions where Asps are targets for pharmaceutical application of aqua plugs. Identified aqua plugs with promising profiles will serve as lead structures for the development and exploitation of specific aqua Orin inhibitors in novel skin care products and diuretics.

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Finanzierungsplan

CSC - Cost-sharing contracts

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STICHTING KATHOLIEKE UNIVERSITEIT
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Adelbertusplein 1
6500 HB NIJMEGEN
Niederlande

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Letzte Aktualisierung: 12 April 2005

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Permalink: https://cordis.europa.eu/project/id/QLK3-CT-2000-00778/de

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