DETERMINATION OF GENOTOXIC COMPOUNDS IN PROCESSED FOOD

Informazioni relative al progetto

ID dell’accordo di sovvenzione: RM283

Data di avvio

Data di completamento

Finanziato da

• Research and development programme (EEC) in the field of applied metrology and chemical analysis (Community Bureau of Reference - BCR), 1988-1992

Costo totale

Nessun dato

Contributo UE

€ 75 000,00

Coordinato da

Université Catholique de Louvain
Belgium

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Risultati sfruttabili

Determination of genotoxic compounds in processed food

The presence of genotoxic compounds such as heterocyclic amines has been demonstrated in foodstuffs submitted to excessive heating, however, toxicologists are not yet able to agree on maximum exposure levels that can be tolerated by humans. The objective of the project was to support collaborative studies aimed at evaluating the best methods of determination of a series of genotoxic compounds in food matrices. A first intercomparison addressed the instrumental determination of 3 imidazoquinolines (IQ, Me-IQ, Me-IQx) in methanol and showed that whereas the high performance liquid chromatography (HPLC) method worked well, gas liquid chromatography (GLC) was unsatisfactory. Good correlation was obtained for the mutagenicity test (Ames test) and showed a very high mutagenic activity for these compounds. A second intercomparison on the determination of the same compounds in specially prepared meat extract has been carried out.