CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
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A pyrimidodiazepine, 6-acetyl-2-amino-7, 8-dihydro-9H-pyrimido [4,5-b][1,4]diazepin-4(3H)-one, was chemically synthesized. This compound was shown to mimic the essential role of tetrahydrobiopterin in the human immune response mechanism. It is the only synthetic compound known which is able to carry out this natural function of promoting the binding of interleukin 2 to human T cells. Tetrahydrobiopterin exerts its effect by complexing with class 1 human leucocyte antigen (HLA), the active moiety being a hydroxyl group. Molecular modelling showed the active pyrimidodiazepine to have an oxygen atom in approximately the same spatial position as in tetrahydrobiopterin, suggesting that both molecules may engage in hydrogen bonding at the active site of the HLA molecule.
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