NEW REGULATORS IN PTERIDINE AND CYTOKINE DIRECTED DNA DIOSYNTHESIS

Informazioni relative al progetto

ID dell’accordo di sovvenzione: SC1*0257

Progetto chiuso

Data di avvio 1 Ottobre 1989

Data di completamento 30 Giugno 1992

Finanziato da

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Costo totale

Nessun dato

Contributo UE

Nessun dato

Coordinato da

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati sfruttabili

Role of a synthetic pyrimidodiazepine in the human immune system

A pyrimidodiazepine, 6-acetyl-2-amino-7, 8-dihydro-9H-pyrimido [4,5-b][1,4]diazepin-4(3H)-one, was chemically synthesized. This compound was shown to mimic the essential role of tetrahydrobiopterin in the human immune response mechanism. It is the only synthetic compound known which is able to carry out this natural function of promoting the binding of interleukin 2 to human T cells. Tetrahydrobiopterin exerts its effect by complexing with class 1 human leucocyte antigen (HLA), the active moiety being a hydroxyl group. Molecular modelling showed the active pyrimidodiazepine to have an oxygen atom in approximately the same spatial position as in tetrahydrobiopterin, suggesting that both molecules may engage in hydrogen bonding at the active site of the HLA molecule.