NEW REGULATORS IN PTERIDINE AND CYTOKINE DIRECTED DNA DIOSYNTHESIS

Projektinformationen

ID Finanzhilfevereinbarung: SC1*0257

Projekt abgeschlossen

Startdatum 1 Oktober 1989

Enddatum 30 Juni 1992

Finanziert unter

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Gesamtkosten

Keine Daten

EU-Beitrag

Keine Daten

Koordiniert durch

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland

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Verwertbare Ergebnisse

Role of a synthetic pyrimidodiazepine in the human immune system

A pyrimidodiazepine, 6-acetyl-2-amino-7, 8-dihydro-9H-pyrimido [4,5-b][1,4]diazepin-4(3H)-one, was chemically synthesized. This compound was shown to mimic the essential role of tetrahydrobiopterin in the human immune response mechanism. It is the only synthetic compound known which is able to carry out this natural function of promoting the binding of interleukin 2 to human T cells. Tetrahydrobiopterin exerts its effect by complexing with class 1 human leucocyte antigen (HLA), the active moiety being a hydroxyl group. Molecular modelling showed the active pyrimidodiazepine to have an oxygen atom in approximately the same spatial position as in tetrahydrobiopterin, suggesting that both molecules may engage in hydrogen bonding at the active site of the HLA molecule.