NEW REGULATORS IN PTERIDINE AND CYTOKINE DIRECTED DNA DIOSYNTHESIS

Informations projet

N° de convention de subvention: SC1*0257

Projet clôturé

Date de début 1 Octobre 1989

Date de fin 30 Juin 1992

Financé au titre de

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Coût total

Aucune donnée

Contribution de l’UE

Aucune donnée

Coordonné par

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Résultats exploitables

Role of a synthetic pyrimidodiazepine in the human immune system

A pyrimidodiazepine, 6-acetyl-2-amino-7, 8-dihydro-9H-pyrimido [4,5-b][1,4]diazepin-4(3H)-one, was chemically synthesized. This compound was shown to mimic the essential role of tetrahydrobiopterin in the human immune response mechanism. It is the only synthetic compound known which is able to carry out this natural function of promoting the binding of interleukin 2 to human T cells. Tetrahydrobiopterin exerts its effect by complexing with class 1 human leucocyte antigen (HLA), the active moiety being a hydroxyl group. Molecular modelling showed the active pyrimidodiazepine to have an oxygen atom in approximately the same spatial position as in tetrahydrobiopterin, suggesting that both molecules may engage in hydrogen bonding at the active site of the HLA molecule.