Objective
"The retina of vertebrates contains two kinds of photoreceptor cells, the abundant rod cells, containing the rhodopsin pigment, and the much scarcer cone cells, with the blue, green and red cone pigments. Upon photoactivation, they interact and activate a specific heterotrimeric G protein, transducin, initiating the visual signalling phototransduction cascade. To date, little information about the interaction cone pigment-transducin is known.
The main goal of this project is to provide an overall picture that integrates in a coherent scheme the molecular basis of the interaction cone pigment-cone transducin following two approaches. In a first approach, Dr Ramon proposes to unravel the effect of cone degeneration associated mutations found in cone pigments, and transducin α subunit genes. To do that, these mutant proteins will be expressed (using eukaryotic or prokaryotic systems) and characterized by means of immunocytochemic and spectroscopic techniques.
On a second approach, Dr Ramon will study the interaction cone pigment-cone transducin by means of Surface Plasmon Resonance spectroscopy, providing the kinetic features of the biomolecular interactions and NMR spectrosocopy, by determining the conformation of cone transducin upon cone pigment binding
The collaboration of different groups with the host institution -which will allow short stays of the applicant in these laboratories- and their involvement in the development of this project will help to disseminate the results not only Europe, but worldwide.
Cone pigments have not been widely studied due to the scarcer amount in nature as compared with the rod pigment rhodopsin. most of the information available on cone pigment phototransduction is inferred or extrapolated from the rod system due to its similarities with rhodopsin, the prototypical representative of G protein coupled receptors. For this reason, the project herein proposed will represent an important advance in the visual diseases arena."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences condensed matter physics quasiparticles
- engineering and technology materials engineering colors
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
08034 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.