ER Function In Virus Infection

Projektinformationen

ER and Infection

ID Finanzhilfevereinbarung: 331496

Projekt abgeschlossen

Startdatum 29 Juli 2013

Enddatum 24 November 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 183 469,80

EU-Beitrag € 183 469,80

Koordiniert durch

UNIVERSITEIT UTRECHT
Netherlands

Ziel

A major challenge in combating significant human pathogens is the inherent variation of viruses that can evolve to evade the host immune response and antiviral treatment strategies. Our research proposes an interdisciplinary approach to identify novel antiviral targets by interrogating the host cell biology of infection by influenza A virus (IAV), human immunodeficiency virus (HIV) and hepatitis C virus (HCV) using high-throughput RNA interference (RNAi) technologies. More specifically, we propose to understand the dependency of these enveloped viruses on the host endoplasmic reticulum (ER) machinery for virus replication and propagation and how this increased virus burden activates host-ER stress, including the unfolded protein response (UPR). The UPR is implicated in inflammatory signaling and we will further investigate whether these viruses can modulate host immune responses via this pathway. In summary, we have proposed a hypothesis-driven RNAi screen to generate an overview of common host-cell factors exploited by diverse viruses during infection as well as extensive biochemical and functional validation of any sites of conserved virus-protein interactions. Therefore, this work aims to identify novel candidates for further translational research and development as improved, broad-spectrum antiviral treatments to combat infection and associated pathogenesis.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases › RNA viruses › hepatitis C
• medical and health sciences › health sciences › infectious diseases › RNA viruses › influenza
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antivirals

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

UNIVERSITEIT UTRECHT

Kontakt Verwaltung

Ineke Braakman (Prof.)

• EU-Beitrag: € 183 469,80
• Adresse: HEIDELBERGLAAN 8 ; 3584 CS Utrecht ; Niederlande
• Region: West-Nederland › Utrecht › Utrecht
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten